Caffeine and sodium benzoate (Injection)

Caffeine and sodium benzoate (Injection) is used with other supportive therapies to treat respiratory depression (very slow breathing) caused by taking too much narcotic pain medicines or alcohol.

This medicine is to be given only by or under the direct supervision of a doctor.

It is very important that your doctor closely checks your progress while you are receiving this medicine and sees if it is working properly.

Using large doses of this medicine may cause unwanted effects. Tell your doctor right away if you have a headache, anxiety, a fast, pounding, or uneven heartbeat, ringing in the ears, or tingling in the hands and feet.

Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine.

Do not take other medicines unless you have discussed them with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

In deciding to use a medicine, the risks of taking the medicine must be weighed against the benefits it will provide. This is a decision you and your doctor will make together. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also, inform your healthcare professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

No information is available on how age affects the effects of caffeine and sodium benzoate (Injection) in children. Safety and effectiveness have not been established.

Geriatric

No information is available on how age affects the effects of caffeine and sodium benzoate (Injection) in older adults.

Breast Feeding

There are no adequate studies in women to determine the risk to infants when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

While some medicines should not be used together at all, in other cases, two different medicines may be used together even if an interaction might happen. In these situations, your doctor may want to adjust the dose, or other precautions may be needed. When receiving this medicine, it is especially important that your healthcare professional knows if you are taking any of the medicines listed below. The following interactions have been chosen based on their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Riociguat
• Viloxazine

Using this medicine with any of the following medicines is usually not recommended, but may be necessary in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Capmatinib
• Givosiran
• Iobenguane I 131
• Peginterferon Alfa-2b
• Pixantrone
• Ritlecitinib
• Tocilizumab

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used around the time of eating food or certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions. The following interactions have been chosen based on their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or provide you with special instructions about using food, alcohol, or tobacco.

• Tobacco

Other Medical Problems

Having other medical problems may affect the use of this medicine. Make sure to tell your doctor if you have any other medical conditions, especially:

• Heart disease or
• Heart rhythm problems—Use with caution. May worsen these conditions.

Along with its needed effects, a medicine may cause some unwanted effects. Not all of these side effects may happen, but if they do, they may need medical attention.

Check with your doctor or nurse right away if any of the following side effects occur:

Incidence not known

• Extra heartbeats
• fast, pounding, or irregular heartbeat or pulse
• trembling or shaking of the hands or feet

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

• Chest pain or discomfort
• confusion
• confusion about time, place, or person
• decreased urination
• dizziness
• dry mouth
• fainting
• fever
• hallucinations
• holding false beliefs that cannot be changed by fact
• increase in heart rate
• lightheadedness
• pounding or rapid pulse
• rapid breathing
• sleeplessness
• slow heartbeat
• sunken eyes
• thirst
• trouble sleeping
• unable to sleep
• unusual excitement, nervousness, or restlessness
• unusual tiredness or weakness
• wrinkled skin

Some side effects may happen that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Your health care professional may also be able to tell you how to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue, are bothersome, or if you have any questions about them:

Incidence not known

• Anxiety
• continuing ringing, buzzing, or other unexplained noise in the ears
• headache
• hearing loss
• hyperventilation
• increased sensitivity to pain
• increased sensitivity to touch
• irritability
• restlessness
• shortness of breath
• tingling in the hands and feet
• trouble sleeping

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Available Dosage Forms:

• Solution

Therapeutic Class: Stimulant, Respiratory

Chemical Class: Methylxanthine

A nurse or other trained health professional will give you this medicine in a hospital. This medicine is given as a shot into a muscle or into a vein.