Cefuroxime (Oral)

Cefuroxime is used to treat bacterial infections in various parts of the body. It is part of a group of medicines called cephalosporin antibiotics. It works by killing bacteria or stopping them from growing. However, this medicine will not work for colds, flu, or other viral infections.

This medicine is available only with your doctor's prescription.

If your symptoms do not improve within a few days, or if they get worse, contact your doctor.

Cefuroxime may cause diarrhea, and in some cases, it can be severe. Do not take any medicine or give medicine to your child to treat diarrhea without first consulting your doctor. Diarrhea medicines may worsen the diarrhea or make it last longer. If you have any questions about this or if mild diarrhea continues or worsens, consult your doctor.

Before you or your child undergo any medical tests, inform the medical doctor in charge that you are using this medicine. The results of some tests may be influenced by this medicine.

In deciding to use a medicine, you and your doctor must weigh the risks of taking the medicine against the benefits it may provide. For this medicine, consider the following:

Allergies

Inform your doctor if you have ever had any unusual or allergic reactions to this medicine or any other medicines. Also tell your healthcare professional about any other types of allergies you may have, such as allergies to foods, dyes, preservatives, or animals. For non-prescription products, carefully read the label or package ingredients.

Pediatric

Studies conducted so far have not shown any pediatric-specific issues that would limit the usefulness of cefuroxime in children. However, safety and effectiveness have not been established in infants younger than 3 months of age.

Geriatric

Studies conducted so far have not shown any geriatric-specific issues that would limit the usefulness of cefuroxime in the elderly.

Breast Feeding

There are no adequate studies in women to determine the risk to infants when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Some medicines should not be used together at all, while in other cases, two different medicines may be used together even if an interaction might occur. In these situations, your doctor may want to adjust the dose, or take other precautions. It is particularly important for your healthcare professional to know if you are taking any of the medicines listed below while you are taking this medicine. The following interactions have been highlighted based on their potential significance and are not necessarily a complete list.

Using this medicine with any of the following medicines is usually not recommended, but may be necessary in some cases. If both medicines are prescribed together, your doctor may change the dose or the frequency of use for one or both of the medicines.

• Aluminum Carbonate, Basic
• Aluminum Hydroxide
• Aluminum Phosphate
• Calcium Carbonate
• Calcium Silicate
• Cimetidine
• Dexlansoprazole
• Dihydroxyaluminum Aminoacetate
• Dihydroxyaluminum Sodium Carbonate
• Ebrotidine
• Esomeprazole
• Famotidine
• Lansoprazole
• Magaldrate
• Magnesium Carbonate
• Magnesium Hydroxide
• Magnesium Oxide
• Magnesium Peroxide
• Magnesium Trisilicate
• Nizatidine
• Omeprazole
• Pantoprazole
• Rabeprazole
• Ranitidine
• Ranitidine Bismuth Citrate
• Roxatidine
• Sodium Bicarbonate

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be taken at the same time as eating food or certain types of food, as interactions may happen. Drinking alcohol or using tobacco with certain medicines may also cause interactions. Discuss with your healthcare professional about using your medicine with food, alcohol, or tobacco.

Other Medical Problems

Having other medical problems may affect how you can use this medicine. Be sure to tell your doctor if you have any other medical issues, especially:

• Colitis (inflammation in the gut), history of—Use with caution. It may worsen these conditions.
• Diarrhea, severe, history of—Use with caution. It may worsen these conditions.
• Kidney disease—Use with caution. Effects may be increased due to slower removal of the medicine from the body.
• Phenylketonuria (PKU)—The oral liquid form of this medicine contains phenylalanine, which can make this condition worse.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Chills
• diarrhea
• fever
• general feeling of illness or discomfort
• headache
• itching of the vagina or genital area
• pain during sexual intercourse
• rigidity
• sweating
• thick, white vaginal discharge with no odor or with a mild odor

Less common

• Black, tarry stools
• chest pain
• cough
• loose stools
• painful or difficult urination
• shortness of breath
• sore throat
• sores, ulcers, or white spots on the lips or in the mouth
• swollen glands
• unusual bleeding or bruising
• unusual tiredness or weakness

Rare

• Back, leg, or stomach pains
• bladder pain
• bleeding gums
• bloody or cloudy urine
• body aches or pain
• burning while urinating
• dark urine
• difficulty with breathing
• ear congestion
• fast, pounding, or irregular heartbeat or pulse
• frequent urge to urinate
• general body swelling
• loss of appetite
• loss of voice
• lower back or side pain
• nasal congestion
• nausea or vomiting
• nosebleeds
• pain or tenderness around the eyes and cheekbones
• pale skin
• pink or red urine
• sneezing
• stuffy or runny nose
• swelling of the joints
• swollen glands
• tightness of chest or wheezing
• white or brownish vaginal discharge
• white patches in the mouth or throat or on the tongue
• white patches with diaper rash
• yellowing of the eyes or skin

Incidence not known

• Blistering, peeling, or loosening of the skin
• bloody, black, or tarry stools
• clay-colored stools
• cough or hoarseness
• coughing up blood
• decrease in urine output or decrease in urine-concentrating ability
• feeling of discomfort
• fever with or without chills
• general feeling of tiredness or weakness
• high fever
• hives
• increased menstrual flow or vaginal bleeding
• joint or muscle pain
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• light-colored stools
• paralysis
• prolonged bleeding from cuts
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• red or black, tarry stools
• red or dark brown urine
• red skin lesions, often with a purple center
• red, irritated eyes
• seizures
• swollen lymph glands
• swollen or painful glands
• unpleasant breath odor
• upper right abdominal or stomach pain
• vomiting of blood

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• Bad, unusual, or unpleasant (after) taste
• change in taste
• diaper rash

Rare

• Abdominal or stomach cramps
• acid or sour stomach
• belching
• bloated
• difficulty with moving
• excess air or gas in the stomach or intestines
• flushing or redness of the skin
• full feeling
• gas in the stomach
• heartburn
• indigestion
• irritability
• irritation or soreness of the mouth
• itching skin
• muscle pain or stiffness
• muscle spasm of the neck
• passing gas
• restlessness
• sleepiness or unusual drowsiness
• stomach discomfort, upset, or pain
• swelling of the tongue
• thirst
• trouble sitting still
• unusually warm skin
• watering of the mouth and drooling
• weight loss

Incidence not known

• Hives or welts
• redness of the skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Ceftin

Available Dosage Forms:

• Tablet
• Powder for Suspension

Therapeutic Class: Antibiotic

Pharmacologic Class: 2nd Generation Cephalosporin

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

Ceftin® oral liquid works differently than Ceftin® tablets, even at the same dose (number of milligrams). Do not switch from the tablets to the oral liquid unless your doctor tells you to.

The oral liquid form must be taken with meals, while the tablet form may be given with or without food.

Swallow the tablets whole. Do not break, crush, or chew it.

Shake the oral liquid well before each use. Measure the medicine with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid.

Keep using this medicine for the full treatment time, even if you feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For infections: For oral dosage form (film-coated tablets): Adults and teenagers—250 to 500 milligrams (mg) two times a day for 10 days. Gonorrhea is treated with a single 1-gram (g) dose. Children (who can swallow the tablets)—250 mg two times a day for 10 days. Children (who cannot swallow the tablets)—Use is not recommended. For oral dosage form (suspension): Children 3 months to 12 years of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 20 to 30 milligrams (mg) per kilogram (kg) of body weight per day divided into two doses, taken for 10 days. However, the dose is usually not more than 1000 mg. Infants up to 3 months—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the oral liquid in the refrigerator. Throw away any unused medicine after 10 days.

Store the tablets in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.