Ciprofloxacin (Intratympanic)

Ciprofloxacin ear suspension is used to treat bilateral otitis media with effusion (a middle ear infection with thick or sticky fluid behind the eardrum) in children who are having tubes placed in their ears. Ciprofloxacin is part of a group of medicines called fluoroquinolone antibiotics. It works by killing bacteria or stopping them from growing.

This medicine should be given by or under the direct supervision of your doctor.

Your doctor will monitor your child's progress closely while they are taking this medicine. This will help your doctor determine if the medicine is effective and if your child should keep taking it.

Call your child's doctor immediately if your child has fluid that keeps draining from the ear beyond the first few days after the ear tube surgery, or if the ear becomes painful.

In deciding to use a medicine, the risks of using the drug must be weighed against the beneficial it will do. This is a decision you and your doctor will make. For this medication, the following should be considered:

Allergies

Inform your clinician if you have ever had any unusual or allergic reaction to this drug or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific issues that would limit the usefulness of ciprofloxacin ear suspension in children. However, safety and efficacy have not been established in children younger than 6 months of age.

Geriatric

No guidance is available on the relationship of age to the effects of ciprofloxacin ear suspension in geriatric patients.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks prior to using this medication while breastfeeding.

Interactions with Medicines

Although certain medications should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your physician may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the drugs listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this drug with any of the following drugs is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Agomelatine
• Bepridil
• Cisapride
• Dronedarone
• Eliglustat
• Fezolinetant
• Flibanserin
• Levoketoconazole
• Mesoridazine
• Pimozide
• Piperaquine
• Saquinavir
• Sparfloxacin
• Terfenadine
• Thioridazine
• Tizanidine
• Ziprasidone

Using this medicine with any of the following medicines is typically not advised, but may be required in some cases. If both medicines are prescribed together, your clinician may change the dose or how often you use one or both of the medications.

• Acalabrutinib
• Acarbose
• Acecainide
• Adagrasib
• Albiglutide
• Alfentanil
• Alfuzosin
• Alogliptin
• Alosetron
• Alprazolam
• Amiodarone
• Amisulpride
• Amitriptyline
• Amoxapine
• Anagrelide
• Apomorphine
• Aprepitant
• Aripiprazole
• Aripiprazole Lauroxil
• Arsenic Trioxide
• Artemether
• Asenapine
• Astemizole
• Atazanavir
• Avapritinib
• Azimilide
• Azithromycin
• Bendamustine
• Benzhydrocodone
• Betamethasone
• Bosutinib
• Bretylium
• Brigatinib
• Budesonide
• Buprenorphine
• Bupropion
• Buserelin
• Canagliflozin
• Ceritinib
• Chlorpromazine
• Chlorpropamide
• Cholera Vaccine, Live
• Cilostazol
• Citalopram
• Clarithromycin
• Clofazimine
• Clomipramine
• Clothiapine
• Clozapine
• Codeine
• Colchicine
• Corticotropin
• Cortisone
• Cosyntropin
• Crizotinib
• Cyclobenzaprine
• Dabrafenib
• Dapagliflozin
• Daridorexant
• Dasatinib
• Deflazacort
• Degarelix
• Delamanid
• Desipramine
• Deslorelin
• Deutetrabenazine
• Dexamethasone
• Dexmedetomidine
• Dihydrocodeine
• Disopyramide
• Dofetilide
• Dolasetron
• Domperidone
• Donepezil
• Doxorubicin
• Doxorubicin Hydrochloride Liposome
• Droperidol
• Dulaglutide
• Duloxetine
• Efavirenz
• Elacestrant
• Elexacaftor
• Empagliflozin
• Encorafenib
• Entrectinib
• Erlotinib
• Ertugliflozin
• Erythromycin
• Escitalopram
• Etrasimod
• Exenatide
• Fenfluramine
• Fentanyl
• Fexinidazole
• Finerenone
• Fingolimod
• Flecainide
• Fluconazole
• Fludrocortisone
• Fluocortolone
• Fluoxetine
• Formoterol
• Fosaprepitant
• Foscarnet
• Fostemsavir
• Gatifloxacin
• Gemifloxacin
• Gepirone
• Glasdegib
• Glimepiride
• Glipizide
• Glyburide
• Gonadorelin
• Goserelin
• Granisetron
• Halofantrine
• Haloperidol
• Histrelin
• Hydrocodone
• Hydrocortisone
• Hydroxychloroquine
• Hydroxyzine
• Ibrutinib
• Ibutilide
• Ifosfamide
• Iloperidone
• Imipramine
• Infigratinib
• Inotuzumab Ozogamicin
• Insulin
• Insulin Aspart, Recombinant
• Insulin Bovine
• Insulin Degludec
• Insulin Detemir
• Insulin Glulisine
• Insulin Lispro, Recombinant
• Ivacaftor
• Ivosidenib
• Ketoconazole
• Lapatinib
• Larotrectinib
• Lefamulin
• Leflunomide
• Lemborexant
• Lenvatinib
• Leuprolide
• Levofloxacin
• Linagliptin
• Liraglutide
• Lixisenatide
• Lofexidine
• Lopinavir
• Lumateperone
• Lumefantrine
• Lurasidone
• Lurbinectedin
• Macimorelin
• Magnesium Sulfate
• Mavacamten
• Mefloquine
• Meperidine
• Metformin
• Methadone
• Methotrexate
• Methylprednisolone
• Metronidazole
• Midazolam
• Mifepristone
• Miglitol
• Mirtazapine
• Mitapivat
• Mobocertinib
• Moricizine
• Moxifloxacin
• Mycophenolate Mofetil
• Nafarelin
• Naloxegol
• Nateglinide
• Nilotinib
• Nitisinone
• Norfloxacin
• Nortriptyline
• Octreotide
• Ofloxacin
• Olanzapine
• Olaparib
• Omaveloxolone
• Ondansetron
• Osilodrostat
• Osimertinib
• Oxaliplatin
• Oxycodone
• Ozanimod
• Pacritinib
• Paliperidone
• Palovarotene
• Panobinostat
• Paroxetine
• Pasireotide
• Pazopanib
• Pemigatinib
• Pentazocine
• Pexidartinib
• Phenobarbital
• Pimavanserin
• Pioglitazone
• Pirfenidone
• Pitolisant
• Pomalidomide
• Ponesimod
• Porfimer
• Posaconazole
• Pralsetinib
• Pramlintide
• Prednisolone
• Prednisone
• Primidone
• Procainamide
• Prochlorperazine
• Promethazine
• Propafenone
• Protriptyline
• Quetiapine
• Quinidine
• Quinine
• Quizartinib
• Ranolazine
• Rasagiline
• Relugolix
• Repaglinide
• Ribociclib
• Rimegepant
• Rosiglitazone
• Saxagliptin
• Selpercatinib
• Selumetinib
• Semaglutide
• Sematilide
• Sertraline
• Sevoflurane
• Simeprevir
• Simvastatin
• Siponimod
• Sirolimus Protein-Bound
• Sitagliptin
• Sodium Phosphate
• Sodium Phosphate, Dibasic
• Sodium Phosphate, Monobasic
• Solifenacin
• Sonidegib
• Sorafenib
• Sotalol
• Sparsentan
• Sufentanil
• Sulpiride
• Sunitinib
• Tacrolimus
• Tasimelteon
• Tazemetostat
• Tedisamil
• Telavancin
• Telithromycin
• Teriflunomide
• Tetrabenazine
• Tezacaftor
• Theophylline
• Tolazamide
• Tolbutamide
• Tolvaptan
• Toremifene
• Tramadol
• Trazodone
• Triamcinolone
• Triclabendazole
• Trifluoperazine
• Trimipramine
• Triptorelin
• Ubrogepant
• Vandetanib
• Vardenafil
• Vemurafenib
• Venetoclax
• Venlafaxine
• Vilanterol
• Vinflunine
• Voclosporin
• Voglibose
• Voriconazole
• Warfarin
• Zanubrutinib
• Zolpidem
• Zuclopenthixol

Using this drug with any of the following medications may cause an increased risk of certain adverse effects, but using both drugs may be the best treatment for you. If both medications are prescribed together, your doctor may change the dose or how often you use one or both of the medications.

• Aceclofenac
• Aminolevulinic Acid
• Amlodipine
• Chloroquine
• Cyclosporine
• Diclofenac
• Dutasteride
• Fosphenytoin
• Itraconazole
• Lanthanum Carbonate
• Phenytoin
• Probenecid
• Rifapentine
• Ropinirole
• Ropivacaine
• Sildenafil
• Suvorexant

Interactions with Food/Tobacco/Alcohol

Certain medications should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medications may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this drug with any of the following may cause an increased chance of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how frequently you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Caffeine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Less common

• Fever
• headache
• muscle aches
• sore throat
• stuffy or runny nose
• unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• Irritability

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Otiprio

Available Dosage Forms:

• Suspension

Therapeutic Class: Antibiotic

Chemical Class: Fluoroquinolone

A doctor or other healthcare professional will give your child this medicine. This medicine is to be given through a needle into your child's middle ear.