CIS-MDP (Intravenous)

Technetium Tc 99m medronate injection is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to find and treat certain diseases or to study how the body's organs function.

Technetium Tc 99m medronate injection is used to help your doctor see images of your bones to help diagnose bone problems.

This medicine should only be given by or under the direct supervision of a doctor who has specialized training in nuclear medicine.

It is very important for your doctor to monitor you closely while you are taking this medicine. This will help your doctor determine if the medicine is working correctly and decide if you should keep using it.

While using this medicine, you may be exposed to radiation. Speak with your doctor if you have any concerns about this.

Before undergoing any medical tests, inform the medical doctor in charge that you are using this medicine. The results of certain tests (e.g., brain imaging or scan) may be influenced by this medicine.

In deciding to use a diagnostic test, any risks of the test must be weighed against the benefits it will provide. This is a decision you and your doctor will make together. Additionally, other factors may influence test results. For this test, the following should be taken into account:

Allergies

Inform your doctor if you have ever had any unusual or allergic reactions to this medicine or any other medicines. Also, let your healthcare professional know if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been done to understand how age relates to the effects of technetium Tc 99m medronate injection in children. Safety and effectiveness have not been determined.

Geriatric

There is no information available on how age affects the use of technetium Tc 99m medronate injection in older patients. However, the quality of the bone scan may be impacted by aging.

Breast Feeding

Studies in breastfeeding women have shown harmful effects on infants. An alternative to this medication should be prescribed, or you should stop breastfeeding while using this medicine.

Interactions with Medicines

Some medicines should not be used together under any circumstances, while in other cases, two different medicines may be used together even if an interaction could happen. In these situations, your doctor may need to adjust the dose or take other precautions. Inform your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicines.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be taken around the time of eating food or certain types of food because interactions may occur. Using alcohol or tobacco with certain medicines may also lead to interactions. Discuss with your healthcare professional about using your medicine with food, alcohol, or tobacco.

Other Medical Problems

Having other medical issues may affect the use of this diagnostic test. Be sure to tell your doctor if you have any other medical problems, especially:

• Hypocalcemia (low calcium in the blood)—Use with caution. This condition may become worse.

• Kidney disease or
• Obesity—The quality of the bone scan may be affected in patients with these conditions.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do, they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Incidence not known

• Blurred vision
• Chest pain or discomfort
• Chills
• Confusion
• Dizziness
• Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• Fainting
• Fast, slow, or irregular heartbeat
• Fever
• Hives, itching, or redness
• Lightheadedness
• Nausea
• No blood pressure or pulse
• Pounding or rapid pulse
• Skin rash
• Stopping of heart
• Sweating
• Unconsciousness
• Unusual tiredness or weakness
• Vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome, or if you have any questions about them:

Incidence not known

• Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your health care professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• CIS-MDP
• MPI MDP
• Osteolite

Available Dosage Forms:

• Kit

Therapeutic Class: Diagnostic Agent, Radiopharmaceutical Imaging

A doctor or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins before you have a bone scan.

You will need to urinate right away and as often as possible for 4 to 6 hours after receiving this medicine. Drink plenty of fluids before and after receiving this medicine so you will pass more urine.