Clenpiq

Clenpiq is a combination medicine used in adults and children who are at least 9 years old to prepare your bowel before a colonoscopy. Cleaning the bowel helps the doctor see the inside of your colon more clearly during the colonoscopy.

Clenpiq may also be used for reasons not mentioned in this medication guide.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

These instructions explain when and what to eat or drink in the days before your colonoscopy, and when to stop eating solid foods.

Clenpiq is usually taken in 2 doses. Each bottle is one dose. Take the first dose the evening before your colonoscopy and take the second dose the morning of your colonoscopy (about 5 hours before).

Clenpiq is a clear liquid and you may be able to see some particles in it. This is normal and will not make the medicine less effective.

Drink plenty of clear liquids (water, broth, black coffee, tea, clear soda, sports drinks) before, during, and after you take Clenpiq. Avoid foods and beverages that contain pulp or are red or purple in color. You may also eat popsicles (not fruit bars or fudge bars) or gelatin without fruit pieces or toppings.

Drink only clear liquids and avoid alcohol, dairy or non-dairy types of milk, or any drink that you cannot see through.

You will need to drink clear liquids up to 2 hours before your colonoscopy. Stop drinking all fluids at least 2 hours before the colonoscopy.

You may need blood tests to check your kidney function and other medical tests before and after your colonoscopy.

This medicine can cause severe dehydration, which can lead to a serious electrolyte imbalance, seizures, or kidney failure. Call your doctor if you are vomiting and cannot drink enough water for your bowel prep, if you have a headache, dizziness, or decreased urination.

Call your doctor if you have any bloating or an upset stomach after your first dose. Your second dose may be delayed until your symptoms improve.

Store at room temperature away from moisture and heat. Do not refrigerate or freeze.

Clenpiq can cause severe dehydration, which can lead to a serious electrolyte imbalance, seizures, kidney failure, or abnormal heartbeats that can cause death.

The risk of dehydration is highest in people with heart problems or kidney disease, or if you take certain other medicines. Tell your doctor about all your current medicines and any that you start or stop using.

Call your doctor if you are sick with vomiting and cannot drink enough water for your bowel prep, if you have a headache, dizziness, or decreased urination.

You should not use citric acid, magnesium oxide, or sodium picosulfate if you are allergic to it or any of its ingredients, or if you have:

• a stomach or bowel obstruction, paralytic ileus, colitis, or toxic megacolon;
• a perforation (a hole or tear) of your intestines;
• slow digestion; or
• severe kidney disease;

Tell your doctor if you have or have ever had:

• dehydration and an electrolyte imbalance (such as low levels of potassium, magnesium, or sodium in your blood);
• a stomach or intestinal disorder, including ulcerative colitis;
• trouble swallowing or gastroesophageal reflux disease (GERD);
• heart problems;
• a seizure;
• fainting;
• alcohol withdrawal syndrome;
• if you have recently used a sedative like Valium, Klonopin, or Xanax (diazepam, alprazolam, clonazepam, lorazepam, and others); or
• kidney problems.

It is not known if Clenpiq will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Ask a doctor if it is safe to breastfeed while using this medicine.

Get emergency medical help if you notice signs of an allergic reaction: hives, difficulty breathing, swelling of your face, lips, tongue, or throat.

Clenpiq may lead to serious side effects. Contact your doctor immediately if you experience:

• dizziness, fainting;
• confusion;
• irregular heartbeats;
• a seizure;
• little or no urination;
• severe nausea or vomiting, painful bloating, severe stomach cramps;
• stomach pain, rectal bleeding;
• trouble drinking liquids; or
• signs of an electrolyte imbalance— increased thirst or urination, constipation, muscle weakness, leg cramps, numbness or tingling, feeling jittery, fluttering in your chest.

Common side effects of Clenpiq may include:

• stomach pain;
• dehydration or dizziness;
• high levels of magnesium in your blood;
• nausea, vomiting; or
• headache.

This is not a complete list of side effects, and others may happen. Contact your doctor for medical advice about side effects. You can report side effects to the FDA at 1-800-FDA-1088.

Call your doctor for instructions if you miss a dose or do not finish all doses before your colonoscopy.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Do not take other laxatives while taking Clenpiq.

Do not drink alcohol while taking Clenpiq and until after your colonoscopy.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Dizziness can cause falls, accidents, or severe injuries.

Clenpiq can make it difficult for your body to absorb other medicines you take within 1 hour of using this medicine.

If you take any of the following medicines, make sure to take them at least 2 hours before or not less than 6 hours after you take Clenpiq:

• chlorpromazine;
• digoxin;
• iron;
• penicillamine; or
• certain antibiotics, such as ciprofloxacin, levofloxacin, moxifloxacin, norfloxacin, doxycycline, minocycline, tetracycline, and others.

Inform your doctor about all the other medicines you are taking, especially:

• a laxative;
• a diuretic or "water pill";
• heart or blood pressure medication;
• medicine for a kidney problem;
• medicine for depression or mental illness;
• seizure medication; or
• NSAIDs (nonsteroidal anti-inflammatory drugs)—aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

This list is not complete. Other drugs may affect Clenpiq, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are mentioned here.

• What is the difference between Clenpiq and Prepopik?