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Colace 2-in-1

Generic name: docusate and senna

Brand names: Colace 2-in-1, Senexon-S, Senna Plus, Senna S, Senna-Time S, Senokot S, SenoSol-SS, Stool Softener + Stimulant Laxative, Stool Softener with Laxative, Dok Plus, Peri-Colace

Used for constipation
Last updated November 2, 2026 0 views
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What is Colace 2-in-1?

Docusate is a stool softener. Senna is a laxative.

Colace 2-in-1 is a combination medicine used to treat occasional constipation.

Colace 2-in-1 may also be used for reasons not mentioned in this medication guide.

This section was rewritten for readability and reviewed for meaning.

Warnings

Use exactly as instructed on the label, or as directed by your doctor.

This section was rewritten for readability and reviewed for meaning.

Before taking this medicine

You should not use Colace 2-in-1 if you are allergic to docusate or senna, or if you are also taking mineral oil.

Ask a doctor or pharmacist if this medicine is safe to use if you have ever had:

  • nausea or vomiting;
  • stomach pain;
  • a sudden change in bowel habits that lasts for 2 weeks or longer; or
  • an intestinal disorder such as Crohn's disease or ulcerative colitis.

Ask a doctor before using this medicine if you are pregnant or breastfeeding.

Do not give this medicine to a child younger than 2 years old without medical advice.

This section was rewritten for readability and reviewed for meaning.

Colace 2-in-1 side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Colace 2-in-1 may cause serious side effects. Stop using Colace 2-in-1 and call your doctor right away if you have:

  • rectal bleeding;
  • severe stomach pain, nausea, vomiting; or
  • no bowel movement.

Common side effects of Colace 2-in-1 may include:

  • gas, bloating;
  • diarrhea; or
  • mild nausea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

This section was rewritten for readability and reviewed for meaning.

How should I use Colace 2-in-1?

Use exactly as directed on the label, or as prescribed by your doctor.

Take Colace 2-in-1 with a full glass of water.

It may be best to take this medicine at night or at bedtime. Colace 2-in-1 should cause you to have a bowel movement within 6 to 12 hours.

Do not take Colace 2-in-1 for longer than 7 days in a row, unless your doctor tells you to.

Call your doctor if your constipation does not improve or if it gets worse after taking Colace 2-in-1.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Since Colace 2-in-1 is used as needed, you might not have a regular dosing schedule. If you miss a dose and it's close to the time for your next dose, just skip the missed dose. Do not take two doses at once.

This section was rewritten for readability and reviewed for meaning.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, vomiting, stomach pain, or diarrhea.

Ask a doctor or pharmacist before using any other laxative or stool softener that may have ingredients similar to docusate or senna.

This section was rewritten for readability and reviewed for meaning.

What other drugs will affect Colace 2-in-1?

Other drugs may affect Colace 2-in-1, including prescription and over-the-counter medicines, vitamins, and herbal products. Inform your doctor about all the medicines you are currently taking and any medicine you begin or stop using.

This section was rewritten for readability and reviewed for meaning.

Related medicines

Before you take this medicine: the information on this page is general and may not cover your personal circumstances. Read the label supplied with your medicine and ask a pharmacist or doctor if you are unsure, especially if you are pregnant, breastfeeding, taking other medicines or managing a long-term condition.
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Content is provided for education and is not medical advice. See our medical disclaimer.