Compazine (Rectal)

Prochlorperazine suppository is used to control severe nausea and vomiting. This medicine should not be used to treat behavioral problems in older adult patients who have dementia.

This medicine is available only with your doctor's prescription.

It is very important for your doctor to check how you and your child are doing at regular visits to ensure this medicine is working properly. Blood tests may be needed to check for side effects.

Check with your doctor before using this medicine with alcohol or other medicines that affect the central nervous system (CNS). Using alcohol or other CNS-affecting medicines with risperidone may make the side effects of this medicine worse, such as dizziness, trouble concentrating, drowsiness, unusual dreams, and sleep problems. Some examples of CNS-affecting medicines include antihistamines or allergy/cold medicines, sedatives, tranquilizers, or sleeping pills, depression medications, anxiety medications, prescription pain medicines or narcotics, attention deficit and hyperactivity disorder medications, seizure medicines or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics.

This medicine may cause extrapyramidal symptoms. Contact your doctor right away if you have trouble speaking, drooling, loss of balance, muscle trembling, jerking, or stiffness, restlessness, a shuffling walk, stiffness in the limbs, twisting body movements, or uncontrolled movements, especially in the face, neck, and back.

This medicine may cause drowsiness, thinking problems, or trouble controlling body movements, which may lead to falls, fractures, or other injuries. Make sure you know how you react to this medicine before driving, using machines, or doing other tasks that require alertness, coordination, or good thinking and vision.

Dizziness, lightheadedness, or fainting may happen, especially when you get up suddenly from lying down or sitting. Getting up slowly may help. If this issue continues or worsens, contact your doctor.

This medicine may make it harder for your body to cool down. Be careful not to overheat during exercise or in hot weather, as overheating may cause heat stroke. Also, be cautious not to get too cold while receiving the risperidone injection. If you get too cold, you may feel drowsy, confused, or clumsy.

Make sure any doctor or dentist treating you knows that you are using prochlorperazine suppository. This medicine may affect certain medical test results.

This medicine may cause tardive dyskinesia (a movement disorder). Contact your doctor right away if you experience any of the following symptoms while using this medicine: lip smacking or puckering, puffing of the cheeks, rapid or worm-like tongue movements, uncontrolled chewing movements, or uncontrolled movements of the arms and legs.

Contact your doctor immediately if you experience any of the following symptoms while using this medicine: convulsions (seizures), breathing difficulties, a fast heartbeat, a high fever, high or low blood pressure, increased sweating, loss of bladder control, severe muscle stiffness, unusually pale skin, or fatigue. These could indicate a serious condition called neuroleptic malignant syndrome (NMS).

Prochlorperazine can temporarily lower your white blood cell count, increasing the risk of infections. If possible, avoid people with infections. Contact your doctor immediately if you think you might be getting an infection or if you develop a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.

Do not take other medicines unless your doctor has discussed them with you. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

In deciding to use a medicine, the risks of using the medication must be weighed against the beneficial it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your physician if you have ever had any unusual or allergic reaction to this medication or any other medicines. Also inform your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of prochlorperazine suppository in children 2 years of age and older or weighing 9 kilograms (kg) (20 pounds (lbs)) and over. Use in children younger than 2 years of age or weighing under 9 kg (20 lbs) is not advised.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of prochlorperazine suppository in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving this medication.

Breast Feeding

There are no adequate studies in women for determining infant chance when using this medicine during breastfeeding. Weigh the potential benefits against the potential risks prior to using this medication while breastfeeding.

Interactions with Medicines

Although certain medications should not be used together at all, in other cases two different medications may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medication, it is especially important that your healthcare professional know if you are using any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following drugs is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Bepridil
• Bromopride
• Cisapride
• Dofetilide
• Dronedarone
• Levoketoconazole
• Mesoridazine
• Metoclopramide
• Pimozide
• Piperaquine
• Potassium Citrate
• Saquinavir
• Sparfloxacin
• Terfenadine
• Thioridazine
• Ziprasidone

Using this medicine with any of the following medications is typically not advised, but may be required in some cases. If both medicines are prescribed together, your clinician may change the dose or how frequently you use one or both of the drugs.

• Adagrasib
• Alfentanil
• Alfuzosin
• Alprazolam
• Amantadine
• Amiodarone
• Amisulpride
• Amitriptyline
• Amoxapine
• Anagrelide
• Apomorphine
• Aprindine
• Aripiprazole
• Aripiprazole Lauroxil
• Arsenic Trioxide
• Asenapine
• Astemizole
• Atazanavir
• Azithromycin
• Benzhydrocodone
• Bromazepam
• Buprenorphine
• Bupropion
• Buserelin
• Butorphanol
• Calcium Oxybate
• Cannabidiol
• Cannabis
• Ceritinib
• Cetirizine
• Chloral Hydrate
• Chloroquine
• Chlorpromazine
• Ciprofloxacin
• Citalopram
• Clarithromycin
• Clobazam
• Clofazimine
• Clomipramine
• Clonazepam
• Clothiapine
• Clozapine
• Codeine
• Crizotinib
• Dabrafenib
• Daridorexant
• Dasatinib
• Degarelix
• Delamanid
• Desipramine
• Deslorelin
• Deutetrabenazine
• Dexmedetomidine
• Dibenzepin
• Dihydrocodeine
• Disopyramide
• Dolasetron
• Domperidone
• Donepezil
• Doxepin
• Doxylamine
• Droperidol
• Duloxetine
• Efavirenz
• Encainide
• Encorafenib
• Enflurane
• Entrectinib
• Epinephrine
• Erythromycin
• Escitalopram
• Esketamine
• Etrasimod
• Fentanyl
• Fexinidazole
• Fingolimod
• Flecainide
• Flibanserin
• Fluconazole
• Fluoxetine
• Formoterol
• Foscarnet
• Fostemsavir
• Gabapentin
• Gabapentin Enacarbil
• Gatifloxacin
• Gemifloxacin
• Gepirone
• Glasdegib
• Glucagon
• Glycopyrrolate
• Glycopyrronium Tosylate
• Gonadorelin
• Goserelin
• Granisetron
• Halofantrine
• Haloperidol
• Halothane
• Histrelin
• Hydrocodone
• Hydromorphone
• Hydroxychloroquine
• Hydroxyzine
• Ibutilide
• Iloperidone
• Imipramine
• Inotuzumab Ozogamicin
• Isoflurane
• Isradipine
• Ivabradine
• Ivosidenib
• Ketamine
• Ketoconazole
• Lacosamide
• Lapatinib
• Lefamulin
• Lemborexant
• Lenvatinib
• Leuprolide
• Levocetirizine
• Levofloxacin
• Levomethadyl
• Levorphanol
• Lidoflazine
• Lithium
• Lofexidine
• Lorcainide
• Loxapine
• Lumefantrine
• Macimorelin
• Magnesium Oxybate
• Mefloquine
• Meperidine
• Methacholine
• Methadone
• Metrizamide
• Metronidazole
• Mifepristone
• Mirtazapine
• Mobocertinib
• Morphine
• Morphine Sulfate Liposome
• Moxifloxacin
• Nafarelin
• Nalbuphine
• Nilotinib
• Norfloxacin
• Nortriptyline
• Octreotide
• Ofloxacin
• Olanzapine
• Ondansetron
• Osilodrostat
• Osimertinib
• Oxaliplatin
• Oxycodone
• Oxymorphone
• Ozanimod
• Pacritinib
• Paliperidone
• Panobinostat
• Paroxetine
• Pasireotide
• Pazopanib
• Pentamidine
• Pentazocine
• Periciazine
• Phenobarbital
• Pimavanserin
• Pitolisant
• Ponesimod
• Porfimer
• Posaconazole
• Potassium Oxybate
• Pregabalin
• Primidone
• Probucol
• Procarbazine
• Promethazine
• Propafenone
• Protriptyline
• Quetiapine
• Quinidine
• Quinine
• Quizartinib
• Ranolazine
• Relugolix
• Remifentanil
• Remimazolam
• Revefenacin
• Ribociclib
• Risperidone
• Ropeginterferon Alfa-2b-njft
• Scopolamine
• Secretin Human
• Selpercatinib
• Sertindole
• Sertraline
• Sevoflurane
• Siponimod
• Sodium Oxybate
• Sodium Phosphate
• Sodium Phosphate, Dibasic
• Sodium Phosphate, Monobasic
• Solifenacin
• Sorafenib
• Sotalol
• Spiramycin
• Sufentanil
• Sulfamethoxazole
• Sulpiride
• Sultopride
• Sunitinib
• Tacrolimus
• Tapentadol
• Telavancin
• Telithromycin
• Tetrabenazine
• Tiotropium
• Topiramate
• Toremifene
• Tramadol
• Trazodone
• Triclabendazole
• Trifluoperazine
• Trimethoprim
• Trimipramine
• Triptorelin
• Vandetanib
• Vardenafil
• Vemurafenib
• Vilanterol
• Vinflunine
• Voclosporin
• Voriconazole
• Zolmitriptan
• Zolpidem
• Zotepine
• Zuclopenthixol
• Zuranolone

Using this medication with any of the following drugs may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your physician may change the dose or how often you use one or both of the drugs.

• Aminolevulinic Acid
• Belladonna
• Belladonna Alkaloids
• Betel Nut
• Evening Primrose
• Phenylalanine
• Procyclidine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may as well cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your clinician may change the dose or how frequently you use this drug, or give you special instructions about the use of food, alcohol, or tobacco.

• Ethanol

Other Medical Issues

The presence of other medical issues may affect the use of this drug. Make sure you tell your doctor if you have any other medical issues, especially:

• Comatose state (unconscious)—Should not be used in patients with this condition.

• Blood or bone marrow issues (eg, agranulocytosis, leukopenia, neutropenia) or
• Breast cancer, history of or
• Glaucoma or
• Liver disease or
• Hypotension (low blood pressure) or
• Seizures—Use with caution. May make these conditions worse.

• Bowel blockage or
• Brain tumor or
• Reye's syndrome—This medicine may mask symptoms in patients with these conditions.

• Dehydration or
• Heart disease or
• Infections (eg, chickenpox, CNS infection, gastroenteritis, measles) or
• Pheochromocytoma (adrenal problem)—May cause adverse effects to become worse.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

• Agitation
• black, tarry stools
• chest pain
• clay-colored stools
• constipation
• dark urine
• decrease in how much or how often you urinate
• diarrhea
• difficulty in swallowing and breathing
• dizziness, faintness, or lightheadedness when suddenly getting up from a lying or sitting position
• drooling
• drowsiness
• dryness of the mouth
• fever and chills
• headache
• inability to have or keep an erection
• loss of appetite
• mask-like face
• nasal congestion
• nausea
• painful or difficult urination
• shuffling walk
• sore throat
• sores, ulcers, or white spots on lips or in the mouth
• stomach pain
• swollen glands
• tightness of the throat
• trembling and shaking of the fingers and hands
• uncontrolled chewing actions and movements of the arms and legs
• unpleasant breath odor
• unusual bleeding or bruising
• unusual tiredness or weakness
• vomiting of blood
• yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

• Change in consciousness
• fast, slow, or irregular heartbeat
• loss of consciousness
• seizures
• severe sleepiness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Incidence not known

• Blurred vision
• increased sensitivity of skin to sunlight
• irregular menstrual periods
• itching, rash, redness, or discoloration of the skin
• jitteriness
• trouble sleeping

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Compazine
• Compro

In Canada

• Pms-Prochlorperazine
• Stemetil

Available Dosage Forms:

• Suppository

Therapeutic Class: Antiemetic

Pharmacologic Class: Phenothiazine

Chemical Class: Piperazine (class)

Use this medicine exactly as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered.

Do not take rectal suppositories by mouth or use it in the vagina.

To use the suppository:

• If the suppository is too soft to insert, chill it in the refrigerator for 20 to 30 minutes or run cold water over it before removing the wrapper.
• Remove the wrapper and moisten the suppository with cool water.
• Lie down on your side and use your finger to push the suppository well up into the rectum.
• Make sure to wash your hands with soap and water before and after using this medicine.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For rectal dosage form (suppository):For severe nausea and vomiting: Adults—25 milligrams (mg) 2 times a day. Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

You may store the suppositories in the refrigerator, but do not freeze them.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

• What drugs cause tardive dyskinesia?