Conivaptan (Intravenous)

Conivaptan injection is used to treat euvolemic hyponatremia (a condition where there is not enough sodium in your blood but with a normal blood volume). Sodium is a chemical that the body needs to function properly. Even with a normal blood volume, a low sodium level can still be harmful to your health. Conivaptan helps to keep the right amount of sodium that the body needs.

This medicine should only be given by your doctor or under their supervision.

It is important for your doctor to check your progress during regular visits. This will help your doctor see if the medicine is working properly and decide if you should continue using it. Blood tests may be needed to check for unwanted effects.

If your symptoms do not improve within a few days or if they get worse, check with your doctor.

You should not use clarithromycin (Biaxin®), indinavir (Crixivan®), itraconazole (Sporanox®), ketoconazole (Nizoral®), or ritonavir (Norvir®). Taking these medicines together may cause serious unwanted effects.

Tell your doctor right away if you have any of the following symptoms after receiving this medicine: slurred speech, trouble speaking, trouble swallowing, seizures, or unusual drowsiness, dullness, tiredness, weakness, or feeling sluggish. These may be signs of a nerve problem called osmotic demyelination syndrome.

This medicine may make you feel dizzy or lightheaded. Do not drive or do anything that could be dangerous until you know how this medicine affects you.

Do not take other medicines unless your doctor has discussed them with you. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

In deciding to use a medicine, the chances of using the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this drug, the following should be considered:

Allergies

Inform your physician if you have ever had any unusual or allergic reaction to this medicine or any other drugs. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of conivaptan injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific issues that would limit the usefulness of conivaptan injection in the elderly.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks prior to using this medicine while breastfeeding.

Interactions with Medications

Although certain drugs should not be used together at all, in other cases two different medications may be used together even if an interaction might occur. In these cases, your clinician may want to change the dose, or other precautions may be necessary. When you are receiving this drug, it is especially critical that your healthcare professional know if you are using any of the drugs listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medication with any of the following medications is not recommended. Your doctor may decide not to treat you with this drug or change some of the other drugs you take.

• Alfuzosin
• Alprazolam
• Boceprevir
• Clarithromycin
• Cobicistat
• Colchicine
• Delavirdine
• Dronedarone
• Eletriptan
• Eliglustat
• Eplerenone
• Ergotamine
• Finerenone
• Flibanserin
• Gepirone
• Idelalisib
• Indinavir
• Isavuconazonium Sulfate
• Itraconazole
• Ivabradine
• Ketoconazole
• Levoketoconazole
• Lomitapide
• Lopinavir
• Lurasidone
• Maraviroc
• Mavacamten
• Naloxegol
• Nefazodone
• Nelfinavir
• Nimodipine
• Pacritinib
• Posaconazole
• Ritonavir
• Saquinavir
• Telaprevir
• Telithromycin
• Tolvaptan
• Ubrogepant
• Venetoclax
• Voclosporin
• Voriconazole

Using this medication with any of the following drugs is normally not advised, but may be required in some cases. If both medicines are prescribed together, your clinician may change the dose or how frequently you use one or both of the drugs.

• Acalabrutinib
• Adagrasib
• Ado-Trastuzumab Emtansine
• Afatinib
• Alfentanil
• Amiodarone
• Amlodipine
• Apalutamide
• Apixaban
• Aprepitant
• Aripiprazole
• Artemether
• Atogepant
• Atorvastatin
• Avacopan
• Avanafil
• Avapritinib
• Axitinib
• Bedaquiline
• Belzutifan
• Benzhydrocodone
• Berotralstat
• Betrixaban
• Bosutinib
• Brexpiprazole
• Brigatinib
• Bromocriptine
• Budesonide
• Buprenorphine
• Buspirone
• Cabazitaxel
• Cabozantinib
• Calcifediol
• Carbamazepine
• Cariprazine
• Ceritinib
• Cilostazol
• Cisapride
• Clozapine
• Cobimetinib
• Codeine
• Copanlisib
• Crizotinib
• Cyclosporine
• Dabigatran Etexilate
• Dabrafenib
• Daclatasvir
• Daridorexant
• Darifenacin
• Darunavir
• Dasatinib
• Deflazacort
• Delamanid
• Dexamethasone
• Diazepam
• Digoxin
• Dihydrocodeine
• Dihydroergotamine
• Diltiazem
• Docetaxel
• Domperidone
• Doxorubicin
• Doxorubicin Hydrochloride Liposome
• Duvelisib
• Elacestrant
• Elagolix
• Elbasvir
• Elexacaftor
• Encorafenib
• Entrectinib
• Enzalutamide
• Erlotinib
• Erythromycin
• Estradiol
• Eszopiclone
• Everolimus
• Fedratinib
• Felodipine
• Fentanyl
• Fesoterodine
• Fexinidazole
• Fluconazole
• Fluticasone
• Fosaprepitant
• Fosnetupitant
• Futibatinib
• Gilteritinib
• Glasdegib
• Grazoprevir
• Guanfacine
• Haloperidol
• Hydrocodone
• Hydrocortisone
• Ibrexafungerp
• Ibrutinib
• Ifosfamide
• Infigratinib
• Irinotecan
• Irinotecan Liposome
• Istradefylline
• Ivacaftor
• Ivosidenib
• Ixabepilone
• Ixazomib
• Lapatinib
• Larotrectinib
• Lefamulin
• Lemborexant
• Lenacapavir
• Leniolisib
• Lercanidipine
• Levomilnacipran
• Lorlatinib
• Lovastatin
• Lumacaftor
• Lumateperone
• Lumefantrine
• Lurbinectedin
• Macitentan
• Manidipine
• Meperidine
• Methadone
• Midazolam
• Midostaurin
• Mifepristone
• Mirtazapine
• Mirvetuximab Soravtansine-gynx
• Mitapivat
• Mobocertinib
• Morphine
• Morphine Sulfate Liposome
• Nateglinide
• Neratinib
• Netupitant
• Nifedipine
• Nilotinib
• Nisoldipine
• Olaparib
• Olutasidenib
• Omaveloxolone
• Omeprazole
• Ondansetron
• Osilodrostat
• Oxycodone
• Paclitaxel
• Palbociclib
• Palovarotene
• Panobinostat
• Paritaprevir
• Pazopanib
• Pemigatinib
• Pentazocine
• Pexidartinib
• Phenobarbital
• Pimavanserin
• Pimozide
• Piperaquine
• Pirtobrutinib
• Pixantrone
• Ponatinib
• Pralsetinib
• Primidone
• Progesterone
• Quetiapine
• Quinidine
• Quizartinib
• Ranolazine
• Reboxetine
• Regorafenib
• Relugolix
• Retapamulin
• Ribociclib
• Rifabutin
• Rimegepant
• Ritlecitinib
• Rivaroxaban
• Romidepsin
• Ruxolitinib
• Salmeterol
• Selpercatinib
• Selumetinib
• Sildenafil
• Simeprevir
• Simvastatin
• Sirolimus
• Sirolimus Protein-Bound
• Sonidegib
• Sparsentan
• Sufentanil
• Sunitinib
• Suvorexant
• Tacrolimus
• Tadalafil
• Tamoxifen
• Tamsulosin
• Tazemetostat
• Temsirolimus
• Tenofovir Alafenamide
• Tezacaftor
• Thiotepa
• Tipranavir
• Tocilizumab
• Topotecan
• Toremifene
• Trabectedin
• Tramadol
• Trazodone
• Triazolam
• Trofinetide
• Upadacitinib
• Valbenazine
• Vardenafil
• Vemurafenib
• Venlafaxine
• Verapamil
• Vilanterol
• Vilazodone
• Vincristine
• Vincristine Sulfate Liposome
• Vinflunine
• Vorapaxar
• Zaleplon
• Zanubrutinib
• Ziprasidone
• Zolpidem
• Zuranolone

Using this medicine with any of the following medicines may cause an increased chance of certain adverse effects, but using both drugs may be the best therapy for you. If both medications are prescribed together, your physician may change the dose or how frequently you use one or both of the medicines.

• Aripiprazole Lauroxil

Interactions with Food/Tobacco/Alcohol

Certain drugs should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is not advised. Your doctor may decide not to treat you with this medication, change some of the other drugs you take, or give you special instructions about the use of food, alcohol, or tobacco.

• Grapefruit Juice

Other Medical Issues

The presence of other medical issues may affect the use of this medication. Make sure you inform your physician if you have any other medical issues, especially:

• Anuria (trouble urinating) or
• Hypovolemic hyponatremia (low blood sodium with low blood volume)—Should not be used in patients with these conditions.

• Heart disease (eg, heart failure) or
• Hypotension (low blood pressure) or
• Hypovolemia (low blood volume)—Use with caution. May make these conditions worse.

• Kidney disease, moderate or severe or
• Liver disease, serious—Use with caution. These conditions may increase the concentration of conivaptan in your blood.

Along with its necessary effects, a medicine may cause some unwanted effects. Not all of these side effects may happen, but if they do, they might need medical attention.

Check with your doctor or nurse right away if any of the following side effects occur:

More common

• Bleeding, blistering, burning, coldness, skin discoloration, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the site
• Bloating or swelling of the face, arms, hands, lower legs, ankles, or feet
• Blurred vision
• Decreased urine
• Dizziness
• Dry mouth
• Headache
• Increased thirst
• Irregular heartbeat
• Loss of appetite
• Mood changes
• Muscle pain or cramps
• Nausea or vomiting
• Nervousness
• Numbness or tingling in the hands, feet, or lips
• Pounding in the ears
• Rapid weight gain
• Seizures
• Slow or fast heartbeat
• Tingling of hands or feet
• Unusual tiredness or weakness
• Unusual weight gain or loss

Less common

• Abdominal or stomach pain
• Bladder pain
• Bloody or cloudy urine
• Bluish color
• Change in consciousness
• Changes in skin color
• Chest pain
• Cold sweats
• Confusion
• Cool pale skin
• Cough
• Decreased urination
• Depression
• Difficult, burning, or painful urination
• Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• Drowsiness
• Fainting
• Fear
• Fever or chills
• Flushed, dry skin
• Frequent urge to urinate
• Fruit-like breath odor
• Increase in amount of urine
• Increase in heart rate
• Increased hunger
• Increased urination
• Loss of consciousness
• Lower back or side pain
• Mental changes
• Muscle spasms [tetany] or twitching
• Nightmares
• Pale skin
• Problems in urination
• Rapid breathing
• Shakiness
• Slurred speech
• Sneezing
• Sore mouth or tongue
• Sore throat
• Sunken eyes
• Sweating
• Swelling of the foot or leg
• Tenderness
• Thirst
• Tightness in the chest
• Trembling
• Trouble sleeping
• Troubled breathing with exertion
• Unusual bleeding or bruising
• White patches in the mouth or on the tongue
• Wrinkled skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Diarrhea

Less common

• Difficulty having a bowel movement (stool)
• Redness of the skin
• Unusually warm skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Vaprisol

Available Dosage Forms:

• Solution

Therapeutic Class: Endocrine-Metabolic Agent

Pharmacologic Class: Vasopressin Receptor Antagonist, V1a/V2

A nurse or other trained health professional will give you this medicine in a hospital. This medicine is given through a needle placed in one of your veins.