Corgard (Oral)

Nadolol is used on its own or with other medicines (like hydrochlorothiazide) to treat high blood pressure (hypertension). High blood pressure makes the heart and arteries work harder. If it lasts a long time, the heart and arteries may not work properly. This can harm the blood vessels in the brain, heart, and kidneys, leading to a stroke, heart failure, or kidney failure. High blood pressure may also raise the risk of heart attacks. Controlling blood pressure may help reduce the chances of these problems.

Nadolol is also used to treat severe chest pain (angina).

This medicine is a beta-blocker. It works by changing how certain parts of the body respond to nerve signals, such as the heart. This causes the heart to beat more slowly and lowers blood pressure. When blood pressure goes down, more blood and oxygen reach the heart.

This medicine is available only with your doctor's prescription.

It is very important that your doctor checks your progress at regular visits to ensure this medicine is working properly and to look for unwanted effects.

Nadolol may cause heart failure in some patients. Contact your doctor right away if you experience chest pain or discomfort; dilated neck veins; extreme fatigue; irregular breathing; an irregular heartbeat; shortness of breath; swelling of the face, fingers, feet, or lower legs; weight gain; or wheezing.

This medicine may cause changes in your blood sugar levels. Additionally, this medicine may hide signs of low blood sugar, like a rapid pulse rate. Talk to your doctor if you have these issues or if you notice a change in your blood or urine sugar test results.

Make sure any doctor or dentist treating you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery.

In deciding to use a medicine, you and your doctor need to think about the risks and benefits. For this medicine, consider the following:

Allergies

Inform your doctor if you have ever had an unusual or allergic reaction to this medicine or any other medicines. Also, let your healthcare professional know if you have any other allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, carefully read the label or package ingredients.

Pediatric

There have not been enough studies on how nadolol affects children. Safety and effectiveness have not been confirmed for this age group.

Geriatric

There is no information available on how nadolol affects older adults.

Breast Feeding

There have not been enough studies in women to determine the risk to infants when using this medication while breastfeeding. Consider the potential benefits and risks before taking this medication while breastfeeding.

Interactions with Medicines

Some medicines should not be used together. In other cases, two different medicines may be used together even if there could be an interaction. In these situations, your doctor may want to adjust the dose or take other precautions. It is very important for your healthcare professional to know if you are taking any of the medicines listed below. The following interactions are significant but may not include all possible interactions.

Using this medicine with any of the following medicines is usually not recommended, but may be necessary in some cases. If both medicines are prescribed together, your doctor may adjust the dose or how often you take one or both of the medicines.

• Albuterol
• Ceritinib
• Clonidine
• Crizotinib
• Darunavir
• Diltiazem
• Dronedarone
• Epinephrine
• Fenoldopam
• Fexinidazole
• Fingolimod
• Formoterol
• Indacaterol
• Iobenguane I 131
• Iohexol
• Itraconazole
• Lacosamide
• Levalbuterol
• Lidocaine
• Olodaterol
• Oxymetazoline
• Ponesimod
• Rivastigmine
• Salmeterol
• Siponimod
• Terbutaline
• Verapamil
• Vilanterol

Using this medicine with any of the following medicines may increase the risk of certain side effects, but taking both may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you take one or both of the medicines.

• Acarbose
• Aceclofenac
• Acemetacin
• Acetyldigoxin
• Albiglutide
• Alfuzosin
• Alogliptin
• Amtolmetin Guacil
• Aspirin
• Bromfenac
• Bufexamac
• Bunazosin
• Canagliflozin
• Celecoxib
• Chlorpropamide
• Choline Salicylate
• Clonixin
• Dapagliflozin
• Deslanoside
• Dexibuprofen
• Dexketoprofen
• Diclofenac
• Diflunisal
• Digitoxin
• Digoxin
• Dipyrone
• Doxazosin
• Droxicam
• Dulaglutide
• Empagliflozin
• Ertugliflozin
• Etodolac
• Etofenamate
• Etoricoxib
• Exenatide
• Felbinac
• Fenoprofen
• Fepradinol
• Feprazone
• Floctafenine
• Flufenamic Acid
• Flurbiprofen
• Glimepiride
• Glipizide
• Glyburide
• Ibuprofen
• Indomethacin
• Insulin Aspart, Recombinant
• Insulin Degludec
• Insulin Detemir
• Insulin Glargine, Recombinant
• Insulin Glulisine
• Insulin Human Inhaled
• Insulin Human Isophane (NPH)
• Insulin Human Regular
• Insulin Lispro, Recombinant
• Ketoprofen
• Ketorolac
• Linagliptin
• Liraglutide
• Lixisenatide
• Lornoxicam
• Loxoprofen
• Lumiracoxib
• Meclofenamate
• Mefenamic Acid
• Meloxicam
• Metformin
• Metildigoxin
• Miglitol
• Morniflumate
• Moxisylyte
• Nabumetone
• Naproxen
• Nateglinide
• Nepafenac
• Niflumic Acid
• Nimesulide
• Nimesulide Beta Cyclodextrin
• Oxaprozin
• Oxyphenbutazone
• Parecoxib
• Phenelzine
• Phenoxybenzamine
• Phentolamine
• Phenylbutazone
• Piketoprofen
• Pioglitazone
• Piroxicam
• Pramlintide
• Pranoprofen
• Prazosin
• Proglumetacin
• Propyphenazone
• Proquazone
• Repaglinide
• Rofecoxib
• Rosiglitazone
• Salicylic Acid
• Salsalate
• Saxagliptin
• Sitagliptin
• Sodium Salicylate
• St John's Wort
• Sulindac
• Tamsulosin
• Tenoxicam
• Terazosin
• Tiaprofenic Acid
• Tolazamide
• Tolbutamide
• Tolfenamic Acid
• Tolmetin
• Trimazosin
• Urapidil
• Valdecoxib
• Vildagliptin

Interactions with Food/Tobacco/Alcohol

Some medicines should not be taken around mealtime or with certain foods due to possible interactions. Using alcohol or tobacco with certain medicines may also cause interactions. The following interactions are significant but may not include all possible interactions.

Using this medicine with any of the following may increase the risk of certain side effects but may be necessary in some cases. If used together, your doctor may adjust the dose or how often you take this medicine, or provide special instructions regarding food, alcohol, or tobacco.

• Green Tea

Other Medical Problems

Other medical issues may affect how this medicine works. Be sure to inform your doctor if you have any other medical problems, especially:

• Asthma or
• Bradycardia (slow heartbeat) or
• Heart block or
• Heart failure—This medicine should not be used in patients with these conditions.

• Blood vessel disease—Use with caution. This medicine may make this condition worse.

• Diabetes or
• Hyperthyroidism (overactive thyroid) or
• Hypoglycemia (low blood sugar)—This medicine may hide some signs and symptoms of these conditions, like a fast heartbeat.

• Kidney disease—Use with caution. The effects may be stronger due to slower removal of the medicine from the body.

• Lung disease (e.g., bronchitis, emphysema)—This medicine may cause breathing difficulties in patients with this condition.

Along with its necessary effects, this medicine may cause some unwanted effects. Not all of these side effects may happen, but if they do, they may require medical attention.

Check with your doctor right away if you experience any of the following side effects:

Less common

• Blurred vision
• Chest pain or discomfort
• Confusion
• Dilated neck veins
• Dizziness, faintness, or lightheadedness when suddenly standing up from lying down or sitting
• Extreme fatigue
• Irregular breathing
• Lightheadedness, dizziness, or fainting
• Paleness or cold feeling in fingertips and toes
• Shortness of breath
• Slow or irregular heartbeat
• Sweating
• Swelling of the face, fingers, feet, or lower legs
• Tingling or pain in fingers or toes when exposed to cold
• Unusual tiredness or weakness
• Weight gain
• Wheezing

Rare

• Burning, crawling, itching, numbness, prickling, "pins and needles," or tingling feelings
• Changes in behavior
• Cough
• Difficulty breathing
• Noisy breathing
• Slurred speech
• Tightness in the chest

Some side effects may occur that usually do not need medical attention. These side effects may go away as your body adjusts to the medicine. Your healthcare professional may also be able to suggest ways to prevent or reduce some of these side effects. Check with your healthcare professional if any of the following side effects continue, are bothersome, or if you have any questions about them:

Rare

• Bloated
• Continuing ringing or buzzing or other unexplained noise in the ears
• Decreased interest in sexual intercourse
• Diarrhea
• Difficulty having a bowel movement (stool)
• Drowsiness
• Dry mouth, eyes, or skin
• Excess air or gas in the stomach or intestines
• Full feeling
• Gas in the stomach
• Hair loss, thinning of hair
• Headache
• Hearing loss
• Heartburn
• Inability to have or keep an erection
• Itching skin
• Loss in sexual ability, desire, drive, or performance
• Loss of appetite
• Nausea
• Passing gas
• Rash
• Relaxed and calm
• Sleepiness
• Stomach pain
• Stomach soreness or discomfort
• Stuffy nose
• Vomiting
• Weight loss

Other side effects not listed may also happen in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You can report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Corgard

In Canada

• Alti-Nadolol

Available Dosage Forms:

• Tablet

Therapeutic Class: Cardiovascular Agent

Pharmacologic Class: Beta-Adrenergic Blocker, Nonselective

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium. Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Do not interrupt or stop taking this medicine without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are taking before stopping it completely. Some conditions may become worse when the medicine is stopped suddenly, which can be dangerous.

You may take this medicine with or without food.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets): For high blood pressure: Adults—At first, 40 milligrams (mg) once a day. Your doctor may increase your dose if needed. Children—Use and dose must be determined by your doctor. For severe chest pain: Adults—At first, 40 milligrams (mg) once a day. Your doctor may increase your dose if needed. Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.