Coxanto

Coxanto is a nonsteroidal anti-inflammatory drug (NSAID) that is used in adults to treat the signs and symptoms of osteoarthritis or rheumatoid arthritis. This medicine is also used to treat rheumatoid arthritis in children who are at least 6 years old.

Coxanto may also be used for other purposes not mentioned in this medication guide.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Take the lowest dose that works for your condition.

Your dose may change if you switch to a different brand, strength, or form of Coxanto. Avoid medication errors by using it exactly as directed on the label or as prescribed by your doctor.

Coxanto is usually taken once per day. Follow your doctor's instructions.

Doses are based on weight. Your dose may change if you gain or lose weight.

If you use this medicine for a long time, you may need frequent medical tests.

This medicine may cause false results on a drug-screening urine test. Tell the laboratory staff that you use Coxanto.

Store tightly closed at room temperature, away from moisture, heat, and light.

Coxanto can raise your chances of having a fatal heart attack or stroke. Do not use Coxanto right before or after heart bypass surgery (coronary artery bypass graft, or CABG). This medicine may also lead to stomach or intestinal bleeding, which can be fatal.

Coxanto can raise your chances of having a fatal heart attack or stroke. Do not use this medicine right before or after heart bypass surgery (coronary artery bypass graft, or CABG). This medicine may also lead to stomach or intestinal bleeding, which can be deadly. This can happen without warning, particularly in older adults.

You should not take Coxanto if you are allergic to it, or if you have ever experienced an asthma attack, hives, or a severe allergic reaction (sneezing, runny or stuffy nose, wheezing) after taking aspirin or another NSAID.

Inform your doctor if you have or have ever had:

• congestive heart failure, heart disease, high blood pressure, high cholesterol, diabetes, or if you smoke;
• a heart attack, stroke, or blood clot;
• stomach ulcers or bleeding;
• asthma;
• fluid retention;
• liver disease; or
• kidney disease (or if you are on dialysis).

It may be more difficult for you to become pregnant while using this medicine.

Do not use Coxanto during pregnancy unless directed by your doctor. Using an NSAID in the last 20 weeks can harm the unborn baby or lead to pregnancy complications.

Check with a doctor to see if it is safe to breastfeed while using this medicine.

Get emergency medical help if you have signs of an allergic reaction: (sneezing, runny or stuffy nose; wheezing, trouble breathing, hives, swelling of your face, lips, tongue, or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.

Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, leg swelling, or feeling short of breath.

Coxanto may cause serious side effects. Stop using Coxanto and call your doctor at once if you have:

• any skin rash, no matter how mild, or a patchy skin color that worsens in sunlight;
• flu-like symptoms;
• severe headache, blurred vision, pounding in your neck or ears;
• heart problems--swelling, rapid weight gain, feeling short of breath;
• signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
• liver problems--diarrhea, loss of appetite, nausea, vomiting, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
• kidney problems--swelling, urinating less, feeling tired or short of breath;
• high blood potassium--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement; or
• low red blood cells (anemia)--pale skin, tiredness, feeling light-headed or short of breath, cold hands and feet.

Coxanto may worsen asthma attacks in people who have asthma. Talk with your doctor about your own risk.

Common side effects of Coxanto may include:

• nausea, upset stomach;
• diarrhea, constipation; or
• rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Call your doctor for guidance if you miss a dose.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Avoid drinking alcohol and smoking, as they can increase your risk of stomach bleeding.

Do not take aspirin or other NSAIDs unless your doctor tells you to.

Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may have ingredients similar to Coxanto (such as aspirin, ibuprofen, ketoprofen, or naproxen).

Coxanto could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Ask your doctor before using Coxanto if you take an antidepressant. Taking certain antidepressants with an NSAID may make you bruise or bleed easily.

Coxanto can harm your kidneys, especially if you also use certain medicines for infections, cancer, osteoporosis, organ transplant rejection, high blood pressure, pain, or arthritis (including Advil, Motrin, and Aleve).

Tell your doctor about all your current medicines. Many drugs can affect Coxanto, especially:

• a blood thinner--warfarin, Coumadin, Jantoven;
• medicine used to prevent blood clots--alteplase, clopidogrel, dipyridamole, ticlopidine, and others; or
• steroid medicine (such as prednisone).

This list is not complete, and many other drugs may affect Coxanto. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.