Daptomycin

Daptomycin is an antibiotic that treats complicated bacterial infections of the heart, skin, or blood in adults and children who are at least 1 year old.

Daptomycin is also used when other medications have not worked or have stopped working.

Daptomycin may be used for other reasons that are not mentioned in this medication guide.

Daptomycin can cause muscle tissue breakdown, which can result in kidney failure. Call your doctor immediately if you experience unexplained muscle pain, tenderness, or weakness, especially if you also have fever, unusual tiredness, or dark urine.

You should not use daptomycin if you are allergic to it.

Tell your doctor if you have or have ever had:

• a nerve or muscle disorder;
• diarrhea caused by infection; or
• kidney disease (or if you are on dialysis).

Tell your doctor if you are pregnant or breastfeeding.

Get emergency medical help if you have signs of an allergic reaction: hives, difficulty breathing, swelling of your face, lips, tongue, or throat.

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.

Daptomycin can cause the breakdown of muscle tissue, which can lead to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness, especially if you also have fever, unusual tiredness, or dark urine.

Daptomycin may cause serious side effects. Stop using daptomycin and call your doctor at once if you have:

• severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose);
• numbness, tingling, or burning pain in your hands or feet;
• new or worsening cough, fever, trouble breathing;
• pain in your side or lower back, painful urination, blood or pus in your urine; or
• symptoms of sepsis—confusion, fever or chills, severe drowsiness, fast heartbeats, rapid breathing, feeling very ill.

Common side effects of daptomycin may include:

• chest pain, trouble breathing;
• headache, dizziness;
• stomach pain, vomiting, diarrhea;
• swelling;
• abnormal blood tests;
• fever, rash, itching, increased sweating;
• sleep problems (insomnia);
• pain and burning when you urinate;
• a reaction after receiving injection;
• sore throat; or
• high or low blood pressure.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Daptomycin is given as an infusion into a vein. A healthcare provider may give you this injection or may teach you how to properly use daptomycin by yourself.

Prepare an injection only when you are ready to give it. Call your pharmacist if the medicine looks cloudy, has changed colors or has particles in it. Ask your doctor or pharmacist if you don't understand how to use an injection.

Daptomycin is available in different brand forms. Be sure you understand how to properly prepare and store the medicine.

Your blood and kidney function may need to be tested often.

Antibiotic medicines can cause diarrhea. Tell your doctor if you have diarrhea that is watery or bloody.

Doses are based on weight. Your dose may change if you gain or lose weight.

This medicine may cause false results with certain medical tests. Tell the laboratory staff that you use daptomycin.

Keep using this medicine even if your symptoms quickly improve. Skipping doses could make your infection resistant to medication. Daptomycin will not treat a viral infection (flu or a common cold).

Call your doctor for instructions if you miss a dose.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Follow your doctor's instructions regarding any restrictions on food, drinks, or activities.

Tell your doctor about all your other medicines, especially:

• cholesterol lowering medicine—atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, or simvastatin.

This list is not complete. Other drugs may affect daptomycin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.