Daraxonrasib

Daraxonrasib is used in adults to treat a specific type of pancreatic cancer that has spread to other areas of the body (metastatic).

Daraxonrasib is typically administered after at least one other cancer medicine has been tried, or when a combination cancer treatment cannot be used.

Daraxonrasib may also be used for reasons that are not mentioned in this medication guide.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Do not change your dose or stop taking this medication without your doctor's advice.

Daraxonrasib is usually taken once per day, at the same time each day. Follow your doctor's instructions.

You may take daraxonrasib with or without food, but take it the same way each time.

Swallow the tablet whole and do not crush, chew, or break it.

If you vomit shortly after taking daraxonrasib, do not take another dose. Take your next dose as scheduled.

You may be given other medications to help prevent serious side effects or allergic reactions. Keep taking these medicines for as long as your doctor has prescribed.

Your blood may need to be tested often.

Store at room temperature away from moisture and heat.

Daraxonrasib can cause serious skin problems. Contact your doctor immediately if you experience a rash, itching, dry or cracked skin, or red, swollen, and painful skin around your fingernails or toenails.

Inform your healthcare provider if you have signs of a serious side effect, such as severe diarrhea, mouth sores or ulcers, red or swollen gums, or difficulty swallowing.

Tell your doctor if you have or have ever had health issues or use other medications.

Daraxonrasib can harm an unborn baby if either the mother or the father is using daraxonrasib.

• If you are a woman, you may need to take a pregnancy test before starting this treatment. Use effective birth control while using this medicine and for at least one week after your last dose.
• If you are a man, use birth control if your sex partner can become pregnant. Continue using birth control for at least one week after your last dose.
• Inform your doctor immediately if a pregnancy occurs.

You should not breastfeed while using this medicine and for at least one week after your last dose.

Get emergency medical help if you have signs of an allergic reaction: hives, difficulty breathing, swelling of your face, lips, tongue, or throat.

Daraxonrasib may cause serious side effects. Call your doctor right away if you have:

• severe diarrhea;
• fever, chills, cough with mucus, chest pain, feeling short of breath;
• blisters or ulcers in your mouth, red or swollen gums, trouble swallowing; or
• a hole (perforation) in your digestive tract--fever, severe stomach pain, change in bowel habits.

Your cancer treatments may be delayed, reduced, or permanently stopped if you experience certain side effects.

Common side effects of daraxonrasib may include:

• abnormal blood tests;
• nausea, vomiting, diarrhea, loss of appetite;
• stomach pain;
• bleeding;
• tiredness or weakness;
• skin rash;
• swelling in your arms or legs; or
• swelling, or sores in your mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Usual Adult Dose for Pancreatic Cancer:

300 mg orally once a dayDuration of therapy: Until disease progression or unacceptable toxicityUse: For the treatment of patients with metastatic pancreatic adenocarcinoma who have received at least 1 prior systemic therapy or are not candidates for multiagent systemic therapy

Use the medicine as soon as you can, but skip the missed dose if you are more than 4 hours late for the dose. Do not use two doses at one time.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Avoid exposure to sunlight. Wear protective clothing or a hat and use sunscreen (SPF 30 or higher) when you are outdoors and use moisturizing cream.

Sometimes it is not safe to use certain medicines together. Some drugs can change the levels of other drugs in your blood, which may increase side effects or make the medicines less effective.

Tell your doctor about all your other medicines, especially cyclosporine A or a similar medicine.

Other drugs may affect daraxonrasib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you are using.