Dasiglucagon

Dasiglucagon is used by adults and children who are at least 6 years old with diabetes to treat very low blood sugar (severe hypoglycemia).

Dasiglucagon may also be used for reasons not mentioned in this medication guide.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Hypoglycemia should be treated as quickly as possible. Having low blood sugar for too long can cause seizure, coma, or death.

Dasiglucagon is injected under the skin. A healthcare provider will teach you or your caregiver how to properly use dasiglucagon. Call your doctor after each time you use a dasiglucagon injection.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don't understand how to use an injection.

Prepare an injection only when you are ready to give it. Call your pharmacist if the medicine looks cloudy, has changed colors, or has particles in it.

Do not inject within 2 inches of your navel (belly button). Your healthcare provider will show where to inject dasiglucagon.

After the injection, you should eat a fast-acting source of sugar (fruit juice, glucose gel, hard candy, raisins, or non-diet soda) and then eat a snack or small meal such as cheese or peanut butter and crackers.

If you are a caregiver, get emergency medical help after giving a dasiglucagon injection. If the patient does not improve within 15 minutes, you may need to give a second injection.

Throw away a prefilled syringe or autoinjector after one use, even if there is still medicine left inside. Do not reuse a needle, syringe, or autoinjector. Place them in a puncture-proof "sharps" container and dispose of it following state or local laws. Keep out of the reach of children and pets.

Blood sugar can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your dose or medication schedule.

To keep from having severe hypoglycemia, follow your diet, medication, and exercise routines very closely.

Store in the refrigerator, away from the cooling element. Do not freeze.

You may store this medicine at room temperature for up to 12 months. Protect from light by storing the medicine in the protective case. Throw the medicine away if not used within 12 months. Do not return the medicine to the refrigerator once it has reached room temperature.

You should not use dasiglucagon if you have a tumor of the pancreas (insulinoma) or adrenal gland (pheochromocytoma).

Make sure you and your caregivers know how to give a dasiglucagon injection before you need to use it. Hypoglycemia should be treated as quickly as possible. Having low blood sugar for too long can cause seizure, coma, or death.

You should not use dasiglucagon if you have or have ever had:

• a tumor of the pancreas (insulinoma); or
• pheochromocytoma (tumor of the adrenal gland).

Tell your doctor if you have or have ever had:

• any tumor of the pancreas;
• an allergy to this medicine or any of its ingredients;
• chronic low blood sugar;
• adrenal gland problems;
• an allergy to latex; or
• if you have not had food or water regularly for a long period.

It is not known if dasiglucagon will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Ask a doctor if it is safe to breastfeed while using this medicine.

In an emergency situation, it may not be possible to tell your caregivers if you are pregnant or breastfeeding. Make sure any doctor caring for your pregnancy or your baby knows you have received this medicine.

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Dasiglucagon may cause serious side effects. Call your doctor right away if you experience:

• severe headache, blurred vision, pounding in your neck or ears; or
• low blood sugar—hunger, weakness, sweating, confusion, irritability, dizziness, fast heart rate, or feeling jittery.

Common side effects of dasiglucagon may include:

• nausea, vomiting, diarrhea;
• headache; or
• pain at the injection site.

This is not a complete list of side effects and others may happen. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Usual Adult Dose for Hypoglycemia:

0.6 mg subcutaneously once into lower abdomen, buttocks, thigh, or outer upper armIf there has been no response after 15 minutes, a second 0.6 mg dose may be administered Comments:-Patients/caregivers should be familiar with instructions for use; this drug should be administered as soon as possible when severe hypoglycemia is recognized. -Call for emergency assistance immediately after administering dose.-Once patient has responded to treatment, oral carbohydrates should be given to restore liver glycogen stores. Use: For the treatment of severe hypoglycemia in patients with diabetes.

Usual Pediatric Dose for Hypoglycemia:

6 years or older: 0.6 mg subcutaneously once into lower abdomen, buttocks, thigh, or outer upper armIf there has been no response after 15 minutes, a second 0.6 mg dose may be administeredComments:-Patients/caregivers should be familiar with instructions for use; this drug should be administered as soon as possible when severe hypoglycemia is recognized. -Call for emergency assistance immediately after administering dose.-Once patient has responded to treatment, oral carbohydrates should be given to restore liver glycogen stores. Use: For the treatment of severe hypoglycemia in pediatric patients 6 years or older with diabetes.

Dasiglucagon is used as needed. If you have a dosing schedule and miss a dose, skip it. Do not use two doses at the same time.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Tell your doctor about all your other medicines, especially indomethacin.

Other drugs may affect dasiglucagon, including prescription and over-the-counter medicines, vitamins, and herbal products. Inform your doctor about all other medicines you are using.