Demadex (Intravenous)

Torsemide is a medication that belongs to the group of medicines called loop diuretics. It is used to help reduce the amount of water in the body due to congestive heart failure, liver disease (cirrhosis), or kidney disease. It works by acting on the kidneys to increase urine flow.

Torsemide can also be used alone or with other medicines to treat high blood pressure (hypertension). High blood pressure makes the heart and arteries work harder. If high blood pressure lasts for a long time, it can cause the heart and arteries to not work properly. This can lead to damage in the blood vessels of the brain, heart, and kidneys, which may result in a stroke, heart failure, or kidney failure. High blood pressure can also raise the risk of heart attacks. Controlling blood pressure may help reduce the likelihood of these problems.

This medicine is available only with your doctor's prescription.

Your doctor will only give you a few doses of this medicine until your condition improves, and then you will be switched to another medicine that works the same way. If you have any concerns about this, talk to your doctor.

In deciding to use a medicine, you and your doctor must weigh the risks against the benefits. Here are some important things to consider for this medicine:

Allergies

Tell your doctor if you have ever had any unusual or allergic reactions to this medicine or any other medicines. Also, inform your healthcare professional about any other allergies you have, such as to foods, dyes, preservatives, or animals. For non-prescription products, carefully read the label or package ingredients.

Pediatric

There have not been appropriate studies to determine how torsemide injection affects children. Safety and effectiveness have not been established.

Geriatric

Studies so far have not shown any specific problems in older adults that would limit the usefulness of torsemide injection for them.

Breast Feeding

There are no adequate studies in women to assess the risk to infants when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before using this medication while breastfeeding.

Interactions with Medicines

Some medicines should never be used together, while others can be used together even if an interaction might happen. If you are receiving this medicine, it is very important for your healthcare professional to know if you are taking any of the medicines listed below. The following interactions are highlighted for their significance but may not include all possible interactions.

Using this medicine with the following medicine is not recommended. Your doctor may decide not to treat you with this medication or may change some of your other medicines.

• Desmopressin

Using this medicine with any of the following medicines is usually not recommended but may be necessary in some cases. If both medicines are prescribed, your doctor may adjust the dose or frequency of one or both of the medicines.

• Aceclofenac
• Acemetacin
• Albuterol
• Amtolmetin Guacil
• Arsenic Trioxide
• Aspirin
• Bromfenac
• Bufexamac
• Buprenorphine
• Capecitabine
• Celecoxib
• Ceritinib
• Choline Salicylate
• Clonixin
• Codeine
• Dexibuprofen
• Dexketoprofen
• Diclofenac
• Diflunisal
• Digitoxin
• Dipyrone
• Dofetilide
• Droperidol
• Droxicam
• Etodolac
• Etofenamate
• Etoricoxib
• Felbinac
• Fenoprofen
• Fepradinol
• Feprazone
• Floctafenine
• Fluconazole
• Flufenamic Acid
• Flurbiprofen
• Formoterol
• Foscarnet
• Ibuprofen
• Indomethacin
• Ketanserin
• Ketoprofen
• Ketorolac
• Levomethadyl
• Lithium
• Lornoxicam
• Loxoprofen
• Lumiracoxib
• Mavacamten
• Meclofenamate
• Mefenamic Acid
• Meloxicam
• Methotrexate
• Metolazone
• Morniflumate
• Nabumetone
• Naproxen
• Nepafenac
• Niflumic Acid
• Nimesulide
• Nimesulide Beta Cyclodextrin
• Oxaprozin
• Oxyphenbutazone
• Parecoxib
• Phenobarbital
• Phenylbutazone
• Piketoprofen
• Piroxicam
• Pixantrone
• Primidone
• Proglumetacin
• Propyphenazone
• Proquazone
• Rofecoxib
• Salicylic Acid
• Salsalate
• Sodium Salicylate
• Sotalol
• Sparsentan
• Sulindac
• Tapentadol
• Tenoxicam
• Tiaprofenic Acid
• Tolfenamic Acid
• Tolmetin
• Valdecoxib
• Warfarin

Using this medicine with any of the following medicines may increase the risk of certain side effects, but using both may be the best treatment for you. If both medicines are prescribed, your doctor may change the dose or frequency of one or both of the medicines.

• Benazepril
• Captopril
• Cilazapril
• Enalapril
• Enalaprilat
• Fosinopril
• Germanium
• Ginseng
• Gossypol
• Licorice
• Lisinopril
• Moexipril
• Perindopril
• Quinapril
• Ramipril
• Spirapril
• Trandolapril
• Zofenopril

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used near the time of eating food or specific types of food due to possible interactions. Using alcohol or tobacco with some medicines may also lead to interactions. Talk to your healthcare professional about how to use your medicine with food, alcohol, or tobacco.

Other Medical Problems

Having other medical problems may affect how you use this medicine. Make sure to tell your doctor if you have any other medical issues, especially:

• Anuria (not able to form urine)—Should not use in patients with this condition.

• Diabetes—This medicine may raise blood sugar levels.

• Electrolyte imbalance (e.g., low potassium in the blood) or
• Gout or
• Hearing problems or
• Hypovolemia (low blood volume)—Use with caution. This medicine may make these conditions worse.

• Heart disease—May increase the risk of heart rhythm problems.

• Hyperlipidemia—This medicine may raise cholesterol levels.

• Severe kidney disease or
• Liver disease—Higher blood levels of torsemide may occur, increasing the chance of side effects.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do happen, they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Less common

• Bloating or swelling of the face, arms, hands, lower legs, or feet
• Chest pain
• Rapid weight gain
• Tingling in hands or feet
• Unusual weight gain or loss

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

• Blurred vision
• Coma
• Confusion
• Convulsions
• Decreased urination
• Dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
• Drowsiness
• Dry mouth
• Fast or irregular heartbeat
• Headache
• Increase in heart rate
• Increased thirst
• Irritability
• Loss of appetite
• Mood changes
• Muscle pain or cramps
• Nausea or vomiting
• Numbness in hands, feet, or lips
• Rapid breathing
• Shortness of breath
• Sunken eyes
• Sweating
• Unusual tiredness or weakness
• Weak pulse
• Wrinkled skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome, or if you have any questions about them:

More common

• Increased urination

Less common

• Acid or sour stomach
• Belching
• Diarrhea
• Difficulty having a bowel movement (stool)
• Difficulty in moving
• Heartburn
• Increased cough
• Indigestion
• Lack or loss of strength
• Muscle aching
• Muscle stiffness
• Nervousness
• Pain in joints
• Runny nose
• Sneezing
• Sore throat
• Stomach discomfort, upset, or pain
• Stuffy nose
• Swollen joints

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Demadex

Pharmacologic Class: Diuretic, Loop

A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed into one of your veins.

• What are the equivalent dosages of bumetanide, furosemide & torsemide?