Depemokimab

Depemokimab is used with other medicines to help manage severe asthma in adults and children who are at least 12 years old. Depemokimab is not a quick-relief medicine for asthma attacks.

Depemokimab is given when other treatments have not worked or have stopped working.

Depemokimab may also be used for other reasons not mentioned in this medication guide.

Depemokimab is injected under the skin. A healthcare provider will give you this injection.

Depemokimab is usually given once every 6 months. Follow your doctor's instructions.

Do not change or stop your other medicines, including corticosteroid medicines or other medicines unless your healthcare provider tells you to.

Call your doctor if your symptoms do not improve, or if they get worse.

Depemokimab is not a fast-acting rescue medicine for asthma attacks. Seek medical attention if your breathing problems get worse quickly, or if you think your medications are not working.

Use only as directed. Inform your doctor if you are taking other medicines or have other medical conditions or allergies.

Tell your doctor if you have or have ever had:

• an infection caused by helminthic parasites; or
• an oral or inhaled steroid medicine.

It is not known if depemokimab will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Ask a doctor if it is safe to breastfeed while using depemokimab.

If you are pregnant and receive depemokimab, report your pregnancy exposure. Reporting helps collect information on how depemokimab may affect pregnancy. Talk to your healthcare provider about how to report this information.

Get emergency medical help if you have signs of an allergic reaction: hives, difficulty breathing, swelling of your face, lips, tongue, or throat.

Depemokimab may cause serious side effects. Call your doctor right away if you experience:

• feeling like you might faint; or
• new or worsening asthma symptoms.

Common side effects of depemokimab may include:

• cold symptoms such as stuffy nose, sneezing, sore throat;
• runny or itchy nose;
• joint pain; or
• flu or flu-like symptoms.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Usual Adult Dose for Asthma -- Maintenance:

100 mg subcutaneously every 6 monthsUse: For the add-on maintenance treatment of severe asthma characterized by an eosinophilic phenotype

Usual Pediatric Dose for Asthma -- Maintenance:

12 years and older: 100 mg subcutaneously every 6 monthsUse: For the add-on maintenance treatment of severe asthma characterized by an eosinophilic phenotype

Call your doctor for guidance if you miss an appointment for your depemokimab injection.

In a medical setting, an overdose would be handled promptly.

Follow your doctor's instructions regarding any limits on food, drinks, or activities.

Other drugs may affect depemokimab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.