Diflucan IV (Intravenous)

Fluconazole injection is used to treat serious fungal or yeast infections. This includes oropharyngeal candidiasis (thrush, oral thrush), esophageal candidiasis (candida esophagitis), other candida infections (like urinary tract infections, peritonitis [inflammation of the lining of the stomach], and infections that may happen in different parts of the body), or fungal (cryptococcal) meningitis. This medicine works by killing the fungus or yeast or stopping it from growing.

Fluconazole injection is also used to prevent candidiasis in patients who are having bone marrow transplants or who are receiving cancer or radiation treatment.

This medicine should only be given by a doctor or under their direct supervision.

It is very important for your doctor to check how you or your child is doing at regular visits to ensure this medicine is working properly. Blood tests may be needed to look for unwanted effects.

If your or your child's symptoms do not improve, or if they get worse, consult your doctor. You may need to use this medicine for several months before your infection improves.

You or your child should not use erythromycin (Ery-Tab®), pimozide (Orap®), or quinidine (Cardioquin®) while taking this medicine due to the risk of unwanted side effects.

Using this medicine for a long time or using it too much during pregnancy (especially in the first trimester) can harm your unborn baby. Use an effective form of birth control while taking this medicine and for at least 1 week after the last dose. If you think you may be pregnant while using this medicine, inform your doctor immediately.

This medicine may rarely cause serious liver problems. Contact your doctor right away if you or your child experience stomach pain or tenderness, clay-colored stools, dark urine, decreased appetite, fever, headache, itching, loss of appetite, nausea and vomiting, skin rash, swelling of the feet or lower legs, unusual tiredness or weakness, or yellowing of the eyes or skin.

This medicine may rarely cause a serious allergic reaction, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Inform your doctor right away if you or your child experience a rash, itching, swelling of the face, tongue, and throat, trouble breathing, or chest pain after taking the medicine.

Serious skin reactions can occur in some people while using this medicine. Contact your doctor right away if you or your child develop a skin rash, itching, or any other skin changes during treatment.

Reach out to your doctor immediately if you notice any changes in your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm issue, including QT prolongation.

This medicine may cause problems with the adrenal glands. Contact your doctor right away if you experience darkening of the skin, diarrhea, dizziness, fainting, loss of appetite, mental depression, nausea, skin rash, unusual tiredness or weakness, or vomiting.

This medicine may cause some people to feel dizzy, drowsy, or less alert than usual. Do not drive or engage in any activities that could be dangerous until you know how this medicine affects you.

Do not take other medicines unless you have discussed them with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

In deciding to use a medicine, the risks of taking the medication must be weighed against the good it will do. This is a decision you and your clinician will make. For this medication, the following should be considered:

Allergies

Inform your physician if you have ever had any unusual or allergic reaction to this drug or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of fluconazole injection in children 6 months to 13 years of age. Nevertheless, safety and efficacy have not been established in children younger than 6 months of age.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of fluconazole injection in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require an adjustment in the dose for patients receiving fluconazole injection.

Breast Feeding

There are no adequate studies in women for determining infant chance when using this drug during breastfeeding. Weigh the potential benefits against the potential risks prior to using this medicine while breastfeeding.

Interactions with Drugs

Although certain drugs should not be used together at all, in other cases two different medications may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medication, it is especially essential that your healthcare professional know if you are using any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this drug with any of the following drugs is not advised. Your doctor may decide not to treat you with this drug or change some of the other medicines you take.

• Alfuzosin
• Amiodarone
• Aripiprazole
• Aripiprazole Lauroxil
• Artemether
• Atazanavir
• Bedaquiline
• Bepridil
• Buprenorphine
• Cisapride
• Citalopram
• Clarithromycin
• Clozapine
• Crizotinib
• Dabrafenib
• Dasatinib
• Dofetilide
• Domperidone
• Donepezil
• Dronedarone
• Ebastine
• Eliglustat
• Encorafenib
• Entrectinib
• Erythromycin
• Escitalopram
• Etrasimod
• Flibanserin
• Glasdegib
• Granisetron
• Haloperidol
• Iloperidone
• Itraconazole
• Ivabradine
• Ivosidenib
• Ketoconazole
• Lapatinib
• Levoketoconazole
• Levomethadyl
• Lomitapide
• Lopinavir
• Lumefantrine
• Macimorelin
• Mavacamten
• Mefloquine
• Mesoridazine
• Methadone
• Mifepristone
• Mirtazapine
• Mobocertinib
• Nelfinavir
• Nilotinib
• Ondansetron
• Osilodrostat
• Panobinostat
• Pazopanib
• Pimavanserin
• Pimozide
• Piperaquine
• Pitolisant
• Propafenone
• Quetiapine
• Quinidine
• Quinine
• Ranolazine
• Ribociclib
• Ritonavir
• Saquinavir
• Selpercatinib
• Solifenacin
• Sorafenib
• Sparfloxacin
• Sunitinib
• Tacrolimus
• Tamoxifen
• Telaprevir
• Telithromycin
• Thioridazine
• Toremifene
• Trazodone
• Vandetanib
• Vardenafil
• Vemurafenib
• Vilanterol
• Vinflunine
• Voclosporin
• Voriconazole
• Ziprasidone

Using this medication with any of the following medications is usually not advised, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how frequently you use one or both of the medications.

• Abrocitinib
• Acalabrutinib
• Acenocoumarol
• Adagrasib
• Ajmaline
• Alfentanil
• Alprazolam
• Amisulpride
• Amitriptyline
• Amoxapine
• Anagrelide
• Anisindione
• Apixaban
• Apomorphine
• Aprepitant
• Aprindine
• Arsenic Trioxide
• Asenapine
• Atorvastatin
• Avanafil
• Avapritinib
• Avatrombopag
• Azilsartan
• Azilsartan Medoxomil
• Azithromycin
• Belzutifan
• Benzhydrocodone
• Bosutinib
• Bretylium
• Brexpiprazole
• Brigatinib
• Brotizolam
• Budesonide
• Buserelin
• Buspirone
• Carbamazepine
• Carvedilol
• Celecoxib
• Ceritinib
• Cerivastatin
• Chloral Hydrate
• Chloroquine
• Chlorpromazine
• Cilostazol
• Ciprofloxacin
• Clobazam
• Clofazimine
• Clomipramine
• Clopidogrel
• Clothiapine
• Cobimetinib
• Codeine
• Colchicine
• Conivaptan
• Cyclobenzaprine
• Cyclosporine
• Daridorexant
• Darifenacin
• Darunavir
• Deflazacort
• Degarelix
• Delamanid
• Desipramine
• Deslorelin
• Deutetrabenazine
• Dexlansoprazole
• Dexmedetomidine
• Diazepam
• Dibenzepin
• Dicumarol
• Dihydrocodeine
• Dihydroergotamine
• Disopyramide
• Dolasetron
• Doxepin
• Doxorubicin
• Doxorubicin Hydrochloride Liposome
• Droperidol
• Efavirenz
• Elacestrant
• Eletriptan
• Elexacaftor
• Elvitegravir
• Enflurane
• Eplerenone
• Ergoloid Mesylates
• Ergonovine
• Ergotamine
• Eribulin
• Etravirine
• Everolimus
• Famotidine
• Fedratinib
• Felbamate
• Felodipine
• Fentanyl
• Finerenone
• Fingolimod
• Flecainide
• Fluoxetine
• Flurbiprofen
• Fluticasone
• Fluvastatin
• Formoterol
• Fosaprepitant
• Foscarnet
• Fosphenytoin
• Galantamine
• Gatifloxacin
• Gemifloxacin
• Gepirone
• Gliclazide
• Glimepiride
• Glipizide
• Glyburide
• Gonadorelin
• Goserelin
• Halothane
• Hexobarbital
• Histrelin
• Hydrocodone
• Hydroquinidine
• Hydroxychloroquine
• Hydroxyzine
• Ibrexafungerp
• Ibrutinib
• Ibuprofen
• Ibutilide
• Ifosfamide
• Imipramine
• Indinavir
• Infigratinib
• Inotuzumab Ozogamicin
• Irbesartan
• Isavuconazonium Sulfate
• Isoflurane
• Isradipine
• Ivacaftor
• Lansoprazole
• Larotrectinib
• Lefamulin
• Lemborexant
• Lenvatinib
• Leuprolide
• Levofloxacin
• Levomilnacipran
• Lidoflazine
• Lofexidine
• Lorcainide
• Lorlatinib
• Lornoxicam
• Lovastatin
• Lumateperone
• Lurasidone
• Lurbinectedin
• Macitentan
• Maraviroc
• Meloxicam
• Meperidine
• Mephenytoin
• Mephobarbital
• Meprobamate
• Methotrexate
• Methotrimeprazine
• Methylergonovine
• Metronidazole
• Midazolam
• Midostaurin
• Milnacipran
• Mitapivat
• Mizolastine
• Moricizine
• Moxifloxacin
• Nafarelin
• Naloxegol
• Naproxen
• Nevirapine
• Nifedipine
• Nisoldipine
• Nitrofurantoin
• Norfloxacin
• Nortriptyline
• Octreotide
• Ofloxacin
• Olanzapine
• Olaparib
• Omaveloxolone
• Omeprazole
• Osimertinib
• Ospemifene
• Oxaliplatin
• Oxycodone
• Ozanimod
• Paclitaxel
• Paliperidone
• Palovarotene
• Pantoprazole
• Papaverine
• Parecoxib
• Paritaprevir
• Paroxetine
• Pasireotide
• Pemigatinib
• Pentamidine
• Pentazocine
• Perphenazine
• Pexidartinib
• Phenindione
• Phenobarbital
• Phenprocoumon
• Phenytoin
• Pipamperone
• Pirmenol
• Piroxicam
• Ponesimod
• Posaconazole
• Prajmaline
• Pralsetinib
• Primidone
• Probucol
• Procainamide
• Prochlorperazine
• Proguanil
• Promethazine
• Protriptyline
• Quizartinib
• Rabeprazole
• Rifabutin
• Rimegepant
• Risperidone
• Ruxolitinib
• Selumetinib
• Sertindole
• Sertraline
• Sevoflurane
• Sildenafil
• Simeprevir
• Simvastatin
• Siponimod
• Sirolimus
• Sirolimus Protein-Bound
• Sodium Phosphate
• Sodium Phosphate, Dibasic
• Sodium Phosphate, Monobasic
• Sonidegib
• Sotalol
• Sparsentan
• Spiramycin
• Sufentanil
• Sulfamethoxazole
• Sulpiride
• Sultopride
• Tazemetostat
• Telavancin
• Temsirolimus
• Terfenadine
• Tetrabenazine
• Tezacaftor
• Theophylline
• Ticagrelor
• Tilidine
• Tipranavir
• Tofacitinib
• Tolbutamide
• Tolterodine
• Tolvaptan
• Torsemide
• Tramadol
• Triazolam
• Triclabendazole
• Trifluoperazine
• Trimethoprim
• Trimipramine
• Triptorelin
• Ubrogepant
• Ulipristal
• Valdecoxib
• Venetoclax
• Venlafaxine
• Verapamil
• Vinblastine
• Vincristine
• Vincristine Sulfate Liposome
• Vinorelbine
• Vorinostat
• Vortioxetine
• Warfarin
• Zanubrutinib
• Zidovudine
• Zolmitriptan
• Zolpidem
• Zotepine
• Zuclopenthixol

Using this drug with any of the following medications may cause an increased chance of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medications.

• Amlodipine
• Atevirdine
• Losartan
• Nicardipine
• Prednisone
• Ramelteon
• Rifampin
• Rifapentine
• Rivaroxaban
• Suvorexant
• Tretinoin
• Trimetrexate

Interactions with Food/Tobacco/Alcohol

Certain drugs should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Issues

The presence of other medical problems may affect the use of this medicine. Make sure you inform your clinician if you have any other medical problems, especially:

• Electrolyte issues (mineral imbalance) or
• Heart disease—Use with caution. These conditions may raise your chance of having heart rhythm problems and make the effects of this medicine worse.

• Heart rhythm problems (eg, QT prolongation) or
• Liver disease—Use with caution. May make these conditions worse.

• Kidney disease—Use with caution. The effects may be increased because of slower removal of the drug from the body.

Along with the benefits of this medicine, it may also cause some unwanted effects. Not all of these side effects will happen, but if they do, you may need medical attention.

Check with your doctor or nurse right away if you notice any of the following side effects:

Rare

• Chest tightness
• chills
• clay-colored stools
• cough
• dark urine
• diarrhea
• difficulty with swallowing
• dizziness
• fast heartbeat
• fever
• headache
• hives, itching, or skin rash
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• light-colored stools
• loss of appetite
• nausea and vomiting
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• continuing stomach pain
• unpleasant breath odor
• unusual tiredness or weakness
• upper right abdominal or stomach pain
• vomiting of blood
• yellow eyes and skin

Incidence not known

• Black, tarry stools
• blistering, peeling, or loosening of the skin
• chest pain or discomfort
• decreased urine
• dry mouth
• fainting
• hoarseness
• increased thirst
• irregular or slow heart rate
• joint or muscle pain
• loss of bladder control
• lower back or side pain
• mood changes
• muscle pain or cramps
• muscle spasm or jerking of all extremities
• numbness or tingling in the hands, feet, or lips
• painful or difficult urination
• pale skin
• red skin lesions, often with a purple center
• red, irritated eyes
• seizures
• sore throat
• sores, ulcers, or white spots in the mouth or on the lips
• sudden loss of consciousness
• swollen glands
• unusual bleeding or bruising

Get emergency help right away if you notice any of the following symptoms of overdose:

Symptoms of overdose

• Fearfulness, suspiciousness, or other mental changes
• seeing, hearing, or feeling things that are not there

Some side effects may happen that usually do not require medical attention. These side effects may go away as your body gets used to the medicine. Your healthcare professional might also have suggestions to help prevent or lessen some of these side effects. Check with your healthcare professional if any of the following side effects continue, are bothersome, or if you have any questions about them:

Less common

• Acid or sour stomach
• belching
• change in taste or bad, unusual, or unpleasant (after) taste
• heartburn
• indigestion
• stomach discomfort or upset

Incidence not known

• Hair loss or thinning of the hair

Other side effects not mentioned may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You can report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Diflucan IV

In Canada

• Diflucan

Available Dosage Forms:

• Solution

Therapeutic Class: Antifungal

Chemical Class: Triazole

A nurse or other trained health professional will give you or your child this medicine. This medicine is given through a needle placed in one of your veins.

Your doctor will give you or your child a few doses of this medicine until your condition improves, and then switch you to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

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