Diphenhydramine and naproxen

Diphenhydramine is an antihistamine. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID).

Diphenhydramine and naproxen is a combination medicine used to treat occasional sleeplessness associated with minor aches and pains. Diphenhydramine and naproxen is not for use in treating sleeplessness without pain, or sleep problems that happen often.

Diphenhydramine and naproxen is for use in adults and children who are at least 12 years old.

Diphenhydramine and naproxen may also be used for purposes not listed in this medication guide.

Use exactly as directed on the label, or as prescribed by your doctor. Use the lowest dose that is effective in treating your condition.

Taking too much diphenhydramine can lead to serious heart problems, seizures, coma, or death.

diphenhydramine and naproxen is not approved for use by anyone younger than 12 years old. Always ask a doctor before giving an antihistamine to a child. Death can occur from the misuse of antihistamines in very young children.

Take this medicine with food or milk if it upsets your stomach.

Do not take this medicine if you do not have a full 7 to 8 hours to sleep before being active again. Do not take this medicine for longer than 10 days without your doctor's advice.

Call your doctor if your symptoms do not improve after 10 days, or if they get worse.

If you need surgery or medical tests, tell the surgeon or doctor ahead of time if you have taken this medicine within the past few days.

Store at room temperature away from moisture and heat.

Naproxen can raise your chances of having a fatal heart attack or stroke. Do not use diphenhydramine and naproxen just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Naproxen may also cause stomach or intestinal bleeding, which can be fatal.

Use this medicine exactly as directed. Taking too much diphenhydramine can result in serious heart issues, seizures, coma, or death.

Naproxen can raise your chances of having a fatal heart attack or stroke, even if you have no risk factors. Do not use this medicine right before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Naproxen may also lead to bleeding in your stomach or intestines, which can be deadly. These issues can happen without warning while you are using diphenhydramine and naproxen, especially in older adults.

You should not use this medicine if you are allergic to diphenhydramine or naproxen, or if you have ever experienced an asthma attack or severe allergic reaction after taking aspirin or an NSAID.

Ask a doctor or pharmacist if this medicine is safe for you if you have ever had:

• heart disease, high blood pressure;
• a heart attack, stroke, or blood clot;
• stomach ulcers or bleeding;
• a breathing problem, such as asthma, emphysema, or bronchitis;
• liver or kidney disease;
• glaucoma;
• an enlarged prostate or problems with urination; or
• if you take aspirin to prevent heart attack or stroke.

Ask a doctor before using this medicine if you are pregnant or plan to become pregnant.

If you are pregnant, you should not take this medicine unless your doctor tells you to. Taking an NSAID during the last 20 weeks of pregnancy can cause serious heart or kidney problems in the unborn baby and possible complications with your pregnancy.

Ask a doctor before using this medicine if you are breastfeeding.

Get emergency medical help if you have signs of an allergic reaction (hives, difficulty breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, a red or purple skin rash with blistering and peeling).

Get emergency medical help if you have signs of a heart attack or stroke: chest pain that spreads to your jaw or shoulder, sudden numbness or weakness on one side of your body, slurred speech, leg swelling, or feeling short of breath.

This medicine may cause serious side effects. Stop using this medicine and call your doctor right away if you have:

• any skin rash, no matter how mild;
• a light-headed feeling, as if you might pass out;
• new symptoms, such as redness or swelling with pain; or
• signs of stomach bleeding—bloody or tarry stools, coughing up blood, or vomit that looks like coffee grounds.

Common side effects of diphenhydramine and naproxen may include:

• drowsiness;
• daytime drowsiness, dizziness, or a "hangover" feeling;
• upset stomach or heartburn;
• constipation;
• blurred vision; or
• dry mouth, nose, or throat.

This is not a complete list of side effects, and others may occur. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Usual Adult Dose for Insomnia:

Initial dose: 2 caplets at bedtimeMaximum dose: 2 caplets in 24 hoursUse: To relief occasional sleeplessness associated with minor aches

Usual Adult Dose for Pain:

Initial dose: 2 caplets at bedtimeMaximum dose: 2 caplets in 24 hoursUse: To relief occasional sleeplessness associated with minor aches

Usual Pediatric Dose for Insomnia:

For children over 12 years old.Initial dose: 2 caplets at bedtimeMaximum dose: 2 caplets in 24 hours

Usual Pediatric Dose for Pain:

For children over 12 years old.Initial dose: 2 caplets at bedtimeMaximum dose: 2 caplets in 24 hours

Since diphenhydramine and naproxen is taken as needed, you might not have a regular dosing schedule. If you miss a dose and it's nearly time for your next dose, just skip the missed dose. Do not take two doses at the same time.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Avoid driving or hazardous activity until you know how diphenhydramine and naproxen will affect you. Your reactions could be impaired.

Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may also contain diphenhydramine or naproxen. Also avoid using diphenhydramine anti-itch medicine on your skin.

Avoid taking aspirin unless your doctor tells you to.

Avoid drinking alcohol. It may increase your risk of stomach bleeding.

Ask your doctor before using diphenhydramine and naproxen if you take an antidepressant. Taking certain antidepressants with an NSAID may cause you to bruise or bleed easily.

Ask a doctor or pharmacist before using diphenhydramine and naproxen with any other medications, especially:

• a blood thinner (warfarin, Coumadin, Jantoven);
• a diuretic or "water pill"; or
• diphenhydramine (Benadryl) used on the skin.

This list is not complete. Other drugs may affect diphenhydramine and naproxen, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.