Doxecitine and doxribtimine

Doxecitine and doxribtimine is used to treat thymidine kinase 2 (TK2d) deficiency in both adults and children whose symptoms began at or before age 12.

Doxecitine and doxribtimine may also be used for reasons not mentioned in this medication guide.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Take this medicine with food 3 times a day, about 6 hours apart.

Doses are based on your weight and will be increased based on your treatment response. You or your child's dose may change based on your treatment response or if you gain or lose weight.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Do not open the packets until you are ready to use them. Prepare a new supply each day as directed. Mix the powder only with water. Do not mix with other liquids or foods.

Measure this medicine carefully using the dosing device provided.

If you do not take the full dose or spit out a dose, do not take another dose. Take your next dose at the regular time.

This medicine may be given through a feeding tube. Follow your doctor's instructions or the Instructions for Use.

Doxecitine and doxribtimine may affect your liver. You may need blood tests to check your liver function before and during treatment.

Store the medication packets in the original container at room temperature away from moisture and heat. Store the prepared solution at room temperature or in the refrigerator and discard after 16 hours.

Use only as directed. Inform your doctor if you are taking other medicines or have other medical conditions or allergies.

Tell your doctor if you have or have ever had:

• liver problems.

It is not known if doxecitine and doxribtimine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether doxecitine and doxribtimine passes into breast milk. Ask your doctor about any risk if you are breastfeeding.

Get emergency medical help if you notice signs of an allergic reaction: hives, trouble breathing, or swelling of your face, lips, tongue, or throat.

Doxecitine and doxribtimine may lead to serious side effects. Contact your doctor immediately if you experience:

• liver problems--loss of appetite, nausea, vomiting, stomach pain (in the upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects of doxecitine and doxribtimine can include:

• diarrhea;
• vomiting;
• stomach pain; or
• abnormal liver function tests.

This is not a full list of side effects, and others may occur. Please call your doctor for medical advice about side effects. You can report side effects to the FDA at 1-800-FDA-1088.

Take the missed dose as soon as you remember. If it is less than 2 hours until your next scheduled dose, skip the missed dose and take your next dose at the usual time. Do not take two doses at once.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Do not share doxecitine and doxribtimine with another person, even if they have the same symptoms you have.

Tell your doctor about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.