Drizalma Sprinkle

Drizalma Sprinkle is a serotonin and norepinephrine reuptake inhibitor antidepressant (SNRI).

Drizalma Sprinkle is used to treat major depressive disorder in adults. This medicine is also used to treat general anxiety disorder in adults and children who are at least 7 years old.

Drizalma Sprinkle is also used in adults to treat diabetic nerve pain or chronic muscle or joint pain (such as low back pain and osteoarthritis pain).

Some brands of duloxetine are also used to treat fibromyalgia (a chronic pain disorder). Drizalma is for treating fibromyalgia only in adults. Cymbalta may be used to treat fibromyalgia in adults and children who are at least 13 years old.

Drizalma Sprinkle may also be used for purposes not listed in this medication guide.

Follow all instructions on your prescription label and read all medication guides or instruction sheets. Your doctor may change your dose from time to time. Use the medicine exactly as directed.

Taking Drizalma Sprinkle in higher doses or more often than prescribed will not make it work better and may increase side effects.

Swallow the capsule whole and do not crush, chew, break, or open it.

Take it with or without food.

Your blood pressure will need to be checked regularly.

Tell your doctor if you notice any changes in sexual function, such as loss of interest in sex, trouble having an orgasm, or (for men) issues with erections or ejaculation. Some sexual problems can be treated.

Your symptoms may not improve for up to 4 weeks.

Do not stop using Drizalma Sprinkle suddenly, or you could experience unpleasant symptoms (like agitation, confusion, tingling, or electric shock sensations). Ask your doctor before stopping the medicine.

Store at room temperature away from moisture and heat.

People with depression or mental illness may have thoughts about suicide. Some young people may have more suicidal thoughts when they first start taking a medicine for depression. Contact your doctor immediately if you notice any sudden changes in your mood or behavior, or if you have thoughts about suicide.

Do not stop using Drizalma Sprinkle without first consulting your doctor.

You should not use Drizalma Sprinkle if you are allergic to it.

Do not take Drizalma Sprinkle within 5 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine. A dangerous drug interaction could occur.

Tell your doctor if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. An interaction with Drizalma Sprinkle could cause a serious condition called serotonin syndrome.

Not approved for use by anyone younger than 7 years old.

Tell your doctor if you have ever had:

• heart problems, high blood pressure;
• liver or kidney disease;
• slow digestion;
• a seizure;
• bleeding problems;
• sexual problems;
• narrow-angle glaucoma;
• bipolar disorder (manic depression);
• drug addiction or suicidal thoughts; or
• if you drink large amounts of alcohol.

People with depression or mental illness may have thoughts about suicide. Some young people may have increased suicidal thoughts when first starting a medicine to treat depression. Stay alert to changes in your mood or symptoms. Your family or caregivers should also watch for sudden changes in your behavior.

Taking Drizalma Sprinkle during pregnancy could harm the baby, but stopping the medicine may not be safe for you. Do not start or stop Drizalma Sprinkle without asking your doctor.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of duloxetine on the baby.

If you are breastfeeding, tell your doctor if you notice drowsiness, feeding problems, and slow weight gain in the nursing baby.

Get emergency medical help if you have signs of an allergic reaction (hives, difficulty breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, a red or purple skin rash that blisters and peels).

Tell your doctor right away if you notice any new or sudden changes in your mood or behavior, including new or worsening depression or anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, more active or talkative, or have thoughts about suicide or hurting yourself.

Drizalma Sprinkle may cause serious side effects. Call your doctor immediately if you experience:

• pounding heartbeats or fluttering in your chest;
• feeling light-headed, like you might faint;
• easy bruising or unusual bleeding;
• changes in vision;
• painful or difficult urination;
• liver problems—pain in the upper right side of your stomach, itching, dark urine, jaundice (yellowing of your skin or eyes);
• low blood sodium—headache, confusion, trouble thinking or remembering, weakness, feeling unsteady; or
• manic episodes—racing thoughts, increased energy, needing less sleep, taking risks, feeling agitated or talkative.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Common side effects of Drizalma Sprinkle may include:

• drowsiness;
• nausea, constipation, loss of appetite;
• dry mouth; or
• increased sweating.

This is not a complete list of side effects, and others may occur. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Take the medicine as soon as you can, but skip the missed dose if it is nearly time for your next dose. Do not take two doses at once.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include vomiting, dizziness or drowsiness, seizures, fast heartbeats, fainting, or coma.

Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen, naproxen, Advil, Aleve, Motrin, and others. Using an NSAID with Drizalma Sprinkle may cause you to bruise or bleed easily.

Avoid driving or doing dangerous activities until you know how Drizalma Sprinkle will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Drinking alcohol may increase your risk of liver damage, especially if you take duloxetine.

Sometimes it is not safe to use certain medications together. Some drugs can change the amount of other drugs in your blood, which may increase side effects or make the medications work less well.

Many drugs can affect Drizalma Sprinkle. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all other medicines you are using.