Duraclon (injection)

Duraclon is used along with opioid medication to treat severe pain from cancer when opioid pain medicine alone does not work well enough to relieve the pain.

Duraclon may also be used for other reasons not mentioned in this medication guide.

You should not use Duraclon if you have bleeding problems, or if you take a blood thinner (warfarin, Coumadin).

You should not use Duraclon if you are allergic to it, or if you have:

• bleeding problems; or
• if you take a blood thinner such as warfarin (Coumadin).

Tell your doctor if you have ever had:

• high or low blood pressure;
• heart problems; or
• kidney disease.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

You should not breast-feed while using Duraclon.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Duraclon may cause serious side effects. Call your doctor right away if you have:

• a light-headed feeling, like you might pass out;
• slow heartbeats;
• weak or shallow breathing;
• signs of infection around the infusion catheter, such as warmth, redness, or swelling;
• fever; or
• headache, neck stiffness, vomiting, increased sensitivity to light.

Common side effects of Duraclon may include:

• dizziness, drowsiness;
• depressed mood;
• nausea, dry mouth; or
• confusion.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Duraclon is given around the clock (continuous) using an infusion pump attached to a catheter placed into the space around your spinal cord. A healthcare provider can teach you how to properly use the infusion pump by yourself.

Your breathing, blood pressure, oxygen levels, kidney function, and other vital signs will be watched closely when you first start using Duraclon.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don't understand all instructions.

Do not use the medicine if it has changed colors or has particles in it. Call your pharmacist for new medicine.

Do not stop using Duraclon without first asking your doctor. If you stop using this medicine suddenly, you could have unpleasant withdrawal symptoms (nervousness, agitation, tremors, or increased blood pressure). Ask your doctor how to safely stop using this medicine.

Tell your doctor right away if you stop using Duraclon for any reason.

Store at room temperature away from moisture and heat.

Do not keep leftover Duraclon that is no longer needed. Throw the vial away, even if there is still medicine left inside.

Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

Because this medicine is given all day, you are not likely to miss a dose.

Tell your doctor if your infusion pump stops working, or if your medicine is stopped for any reason.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include changes in blood pressure (severe headache, blurred vision, pounding in your neck or ears, feeling light-headed), slow heartbeats, shallow breathing, extreme drowsiness, limp muscles, seizure, or coma.

Avoid driving or doing dangerous activities until you know how Duraclon will affect you. Dizziness or drowsiness can lead to falls, accidents, or serious injuries.

Avoid getting up too quickly from a sitting or lying position, or you may feel dizzy.

Do not drink alcohol. Dangerous side effects or death could occur.

Using Duraclon with other medications that cause drowsiness or slow down your breathing can lead to serious side effects or death. Consult your doctor before taking opioid medications, sleeping pills, muscle relaxers, or medications for anxiety or seizures.

Inform your doctor about all your other medications, especially those for heart conditions or high blood pressure.

Other medications may impact Duraclon, including both prescription and over-the-counter drugs, vitamins, and herbal products. Let your doctor know about all your current medications and any new medications you begin or stop taking.