Durlobactam-sulbactam

Durlobactam-sulbactam is a combination antibiotic used in adults to treat pneumonia (a lung infection) that began during a hospital stay or while on a ventilator.

Your doctor will confirm that the infection is caused by a specific type of bacteria that can be treated with durlobactam and sulbactam.

Durlobactam-sulbactam may also be used for reasons not mentioned in this medication guide.

Durlobactam-sulbactam is given as an infusion into a vein. A healthcare provider will give you this injection.

Keep using durlobactam-sulbactam even if your symptoms quickly improve. Skipping doses could make your infection resistant to medication. Durlobactam-sulbactam will not treat a viral infection (flu or a common cold).

Your doctor will decide how long to treat you with this medicine.

Your kidney function may need to be checked often.

Antibiotic medicines can cause diarrhea. Tell your medical caregivers if you have diarrhea that is watery or bloody.

Antibiotic medicines can cause diarrhea. Tell your medical caregivers if you have diarrhea that is watery or bloody.

You should not use durlobactam-sulbactam if you are allergic to it, or if you have an allergy to similar antibiotics such as meropenem, cephalexin, cefdinir, amoxicillin, ampicillin, penicillin, and others.

Tell your doctor if you have or have ever had:

• any other allergies;
• diarrhea caused by an infection or antibiotics; or
• kidney disease (or if you are on dialysis).

Tell your doctor if you are pregnant or breastfeeding.

Not approved for use by anyone younger than 18 years old.

Get emergency medical help if you have signs of an allergic reaction: hives, trouble breathing, swelling of your face, lips, tongue, or throat.

Tell your medical caregivers right away if you have:

• severe stomach pain, diarrhea that is watery or bloody (even if it happens months after your last dose).

Common side effects of durlobactam-sulbactam may include:

• low blood levels of potassium;
• diarrhea;
• abnormal liver function tests; or
• anemia (low red blood cells).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Usual Adult Dose for Nosocomial Pneumonia:

Durlobactam 1 g and sulbactam 1 g IV every 6 hoursDuration of therapy: 7 to 14 daysComments:-Limitations of Use: This drug is not indicated for the treatment of hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia caused by pathogens other than susceptible isolates of Acinetobacter baumannii-calcoaceticus complex.-This dosage is recommended for patients with CrCl 45 to 129 mL/min.-The duration of therapy should be guided by the patient's clinical status.Uses: For the treatment of hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia caused by susceptible isolates of A baumannii-calcoaceticus complex

In a medical setting, you are unlikely to miss a dose.

In a medical setting, an overdose would be treated quickly.

Follow your doctor's instructions about any limits on food, drinks, or activities.

Tell your doctor about all your other medicines, especially:

• probenecid.

This list is not complete. Other drugs may affect durlobactam-sulbactam, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.