Eliquis Sprinkle

Eliquis Sprinkle is used to reduce the risk of stroke and blood clots in adults with a heart rhythm disorder called atrial fibrillation that is not caused by a heart valve problem.

Eliquis Sprinkle is also used in adults to treat blood clots in the legs (DVT) or lungs (PE) and to lower your risk of these clots happening again after you have been treated for blood clots.

Eliquis Sprinkle is used in adults after hip or knee replacement surgery to prevent clots that can occur in the legs (deep vein thrombosis, DVT) or in the lungs (pulmonary embolism, PE).

Eliquis Sprinkle is also used in children from birth to less than 18 years of age to treat blood clots in the legs (DVT) or lungs (PE) and to lower the risk of these clots happening again after receiving treatment for at least 5 days.

Eliquis Sprinkle is not approved for use in children who weigh less than 5.7 pounds (2.6 kg).

Eliquis Sprinkle may also be used for reasons not listed in this medication guide.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Eliquis Sprinkle is usually taken twice per day.

Read and carefully follow any Instructions for Use provided with your medicine. If you cannot swallow a tablet whole, you may crush it and mix the medicine with a small amount of applesauce, apple juice, or water.

If your child is prescribed the tablets for oral suspension, it should be mixed with water, infant formula, apple juice, or applesauce. Do not swallow the tablet.

If your child is taking capsules for oral suspension, the capsule should be opened and mixed with water or infant formula only. Do not swallow the capsule.

Mixed medicine should be used right away. Eliquis Sprinkle may also be given through a feeding tube.

Eliquis Sprinkle can also make it easier for you to bleed, even from a minor injury such as a fall or a bump on the head. Tell your doctor or seek emergency medical attention if you fall or hit your head, or have any bleeding that will not stop.

If you have a planned surgery or dental procedure, your doctor may tell you to stop taking Eliquis Sprinkle for a short time.

Doses are based on weight in children and teenagers. Your child's dose may change if the child gains or loses weight.

If your child vomits within 30 minutes after taking Eliquis Sprinkle, take another dose. If the child vomits after more than 30 minutes of taking this medicine, do not take another dose and give the next dose as scheduled.

Do not change your dose or stop taking Eliquis Sprinkle unless your doctor tells you to. If you stop taking this medicine for any reason, your doctor may prescribe another medicine to prevent blood clots. Keep all follow-up visits with your healthcare provider.

Store at room temperature away from moisture and heat.

Do not stop taking Eliquis Sprinkle unless your doctor tells you to. Stopping suddenly can increase your risk of a blood clot or stroke.

Some drugs can raise your risk of bleeding when taken with Eliquis Sprinkle. Inform your doctor about all other medicines you are using.

Call your doctor immediately if you notice signs of bleeding such as: easy bruising, unusual bleeding, unexpected pain or swelling, feeling very weak or dizzy, bleeding gums, nosebleeds, heavy menstrual bleeding, blood in your urine or stools, coughing up blood or vomit that looks like coffee grounds, or any bleeding that will not stop.

Eliquis Sprinkle can cause a very serious blood clot around your spinal cord if you have a spinal tap or receive spinal anesthesia (epidural). Inform any doctor who treats you that you are taking this medicine.

You should not take Eliquis Sprinkle if you are allergic to it or if you have active bleeding from any cause.

Eliquis Sprinkle can cause a serious blood clot if you undergo a procedure such as a spinal tap or receive spinal anesthesia (epidural). This type of blood clot could cause permanent or long-term paralysis.

Eliquis Sprinkle can make it easier for you to bleed, even from a minor injury. Call your doctor if you have any bleeding that will not stop.

Tell your doctor if you have or have ever had:

• artificial heart valve;
• a history of problems with your spine, a spinal surgery, or difficult or repeated spinal taps;
• bleeding problems;
• plan for surgery, or a medical or a dental procedure;
• a thin tube (catheter) placed in your back to give you certain medicine;
• antiphospholipid syndrome, an immune system disorder that increases the risk of blood clots; or
• liver or kidney disease.

It is not known if Eliquis Sprinkle will harm an unborn baby. Taking this medicine during pregnancy may cause bleeding in the mother or the unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Do not breastfeed while taking Eliquis Sprinkle.

Get emergency medical help if you have signs of an allergic reaction: hives, difficulty breathing, swelling of your face, lips, tongue, or throat.

Also seek emergency medical attention if you have symptoms of a spinal blood clot: back pain, numbness, tingling, muscle weakness in your lower body, or loss of bladder or bowel control.

Eliquis Sprinkle can cause you to bleed more easily. Call your doctor right away if you have signs of bleeding such as:

• bruising or bleeding that won’t stop, unusual bleeding (nosebleeds, bleeding gums, vaginal bleeding);
• unexpected pain, joint pain or swelling;
• headache, dizziness, weakness, feeling like you might faint;
• urine that looks red, pink, or brown; or
• bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds.

Common side effects of Eliquis Sprinkle may include:

• bleeding, including heavy menstrual bleeding; or
• headache, vomiting.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Take a missed dose as soon as you remember it on the same day. Take your next dose at the usual time and continue with your twice-daily schedule. Do not take two doses at once.

Get your prescription refilled before you completely run out of medicine.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Avoid activities that may increase your risk of bleeding or injury. Use extra care while shaving or brushing your teeth.

Sometimes it is not safe to use certain medicines together. Some drugs can change the levels of other drugs in your blood, which may increase side effects or make the medicines less effective.

Tell your doctor about all the medicines you are currently taking. Many drugs can affect Eliquis Sprinkle, especially:

• a blood thinner or any other medicines to treat or prevent blood clots such as enoxaparin, warfarin, heparin, clopidogrel, dipyridamole, prasugrel, and others;
• an antidepressant; or
• NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

This list is not complete and many other drugs may affect Eliquis Sprinkle. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.