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Adrenergic bronchodilators inhalation aerosol (0.125 mg/inh)

Epinephrine inhalation

Generic name: epinephrine inhalation

Brand names: Primatene Mist Inhaler

Last updated November 2, 2026 0 views
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What is epinephrine inhalation?

Epinephrine inhalation is used to treat mild symptoms of asthma, including wheezing, chest tightness, and shortness of breath in adults and children who are at least 12 years old.

Epinephrine inhalation may also be used for reasons not mentioned in this medication guide.

This section was rewritten for readability and reviewed for meaning.

Warnings

Do not use this medicine if you have taken an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine.

This section was rewritten for readability and reviewed for meaning.

Before taking this medicine

Do not use epinephrine inhalation if you have taken an MAO inhibitor in the last 14 days. A serious drug interaction could happen. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, and tranylcypromine.

epinephrine inhalation is only for people who have been diagnosed with asthma. Do not use epinephrine inhalation to treat any condition that has not been evaluated by your doctor.

Ask a doctor or pharmacist if this medicine is safe for you if you have or have ever had:

  • heart problems;
  • kidney problems;
  • high blood pressure;
  • a seizure;
  • a thyroid disorder;
  • narrow-angle glaucoma; or
  • diabetes.

Ask a doctor before using this medicine if you are pregnant or breastfeeding.

This section was rewritten for readability and reviewed for meaning.

Epinephrine inhalation side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

epinephrine inhalation may cause serious side effects. Stop using epinephrine inhalation and call your doctor right away if you have:

  • worsening asthma symptoms;
  • rapid heartbeats;
  • a seizure;
  • tremors, nervousness; or
  • trouble sleeping.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

This section was rewritten for readability and reviewed for meaning.

How should I use epinephrine inhalation?

Use exactly as directed on the label, or as prescribed by your doctor.

Read and follow all Instructions for Use. Ask your doctor or pharmacist if you need help.

Epinephrine inhalation is for the mouth (oral use) only:

  • Shake well before use. Inhale the spray through your mouth.
  • Wait at least 4 hours between doses. Do not use more than 8 inhalations in 24 hours.

Before using epinephrine inhalation for the first time, shake the inhaler and prime it with 4 test sprays into the air, away from your face.

Seek medical attention if your breathing problems do not improve after 20 minutes, or if they get worse quickly.

Tell your doctor if you have more than 2 asthma attacks in 1 week.

Do not share this medicine with another person, even if they have the same symptoms you have.

Store at room temperature away from moisture and heat.

Keep the cover on your inhaler when not in use. Store away from open flame or high heat. Do not puncture or burn an empty canister.

Wash the inhaler after each day of use by running water through the mouthpiece for 30 seconds.

What happens if I miss a dose?

Epinephrine inhalation is used as needed.

This section was rewritten for readability and reviewed for meaning.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

  • Avoid foods or beverages that contain caffeine (including coffee, tea, cola, and energy drinks).
  • Also avoid supplements or herbal products that have a stimulant effect.

This section was rewritten for readability and reviewed for meaning.

What other drugs will affect epinephrine inhalation?

Ask a doctor or pharmacist before using epinephrine inhalation with any other medications, especially:

  • other asthma medications;
  • allergy or cold medicine that contains a decongestant;
  • diet pills, appetite suppressants, or medicines to help you lose weight;
  • medicine that contains caffeine (such as medicine for pain, menstrual cramps, or migraine headaches); or
  • medicine to treat depression, mood disorders, or mental illness such as schizophrenia.

This list is not complete and many other drugs may affect epinephrine inhalation. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

This section was rewritten for readability and reviewed for meaning.

Common questions about epinephrine

Can you use an expired EpiPen in an emergency?
If someone is having an anaphylactic reaction, and all you have on hand is a recently expired EpiPen, then use it so long as it is not discolored and does not contain any particles. There is minimal risk in using a recently expired EpiPen, but the benefits are significant. But check the clear viewing window of the pen and if you notice it is discolored or contains particles then don’t use it as the solution may have oxidized, making it less effective. Continue reading
Can you bring an EpiPen on a plane?
You can bring your EpiPen onto a plane – they are a common medical device and they should not cause any fuss when you are going through airport security. You can carry them in your handbag, laptop bag, or other carry-on luggage. It is a very good idea to take your EpiPen with you on the plane because the small confines of an aircraft increase your odds of being exposed to a trigger allergen while you are flying and having an anaphylactic reaction. Continue reading
What's the mechanism of action for epinephrine?
Epinephrine (for example: EpiPen) works by switching on two families of receptors called alpha and beta adrenergic receptors that sit on cells throughout your body. By acting on alpha receptors, it constricts your blood vessels to help maintain your blood pressure and heart function. Through its action on beta receptors, it relaxes the smooth muscle in the airways of your lungs to help relieve shortness of breath and wheezing. Continue reading
Does epinephrine cause vasoconstriction?
Yes, epinephrine causes vasoconstriction (tightening of the blood vessels). This results in increased blood pressure. Continue reading
How much does Auvi-Q cost compared to EpiPen?
The cash price for a 2-pack of Auvi-Q autoinjector is around $300 compared to $650 for an EpiPen 2-pack. Prices can vary depending upon the pharmacy you visit and if you have any coupons or manufacturer discounts. Auvi-Q and EpiPen are brand names for epinephrine autoinjectors. Continue reading
How does neffy work?
Neffy works in the same way as epinephrine injections, activating both alpha and beta receptors to narrow blood vessels. This helps to maintain blood pressure and heart function, and relaxes smooth muscles in the airways of the lungs to make breathing easier. neffy may also relax the smooth muscles of the stomach and intestine to relieve digestive symptoms often associated with anaphylaxis, such as nausea. Continue reading
What is the difference between Symjepi and EpiPen?
EpiPen and Symjepi are prescription epinephrine products used to treat life-threatening allergic reactions (anaphylaxis). Although they contain the same medicine, they differ in how they are used. Learn how the devices compare, including injection method, size, generic availability, and other key differences. Continue reading

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Before you take this medicine: the information on this page is general and may not cover your personal circumstances. Read the label supplied with your medicine and ask a pharmacist or doctor if you are unsure, especially if you are pregnant, breastfeeding, taking other medicines or managing a long-term condition.
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Content is provided for education and is not medical advice. See our medical disclaimer.