Etripamil nasal

Etripamil is used in adults to treat sudden episodes of fast heartbeat called paroxysmal supraventricular tachycardia (PSVT).

Etripamil may also be used for other reasons that are not mentioned in this medication guide.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Do not take by mouth. Etripamil nasal is for use only in your nose.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Use etripamil nasal as soon as possible after your PSVT symptoms begin. Symptoms may include: sudden rapid heartbeat, palpitations, dizziness, shortness of breath, or chest discomfort.

To use the nasal spray:

• Each device contains 1 dose made up of 2 sprays (1 spray in each nostril). Do not test or prime it before using.
• With your head upright and while sitting, insert the etripamil device into one nostril and spray once by pressing the plunger firmly and quickly all the way down and releasing it. Breathe in gently.
• Use in your other nostril the same way. Keep your head straight for 10 minutes.
• If you still have symptoms after 10 minutes, give a second dose (1 spray in each nostril).
• Lie down if you feel dizzy or lightheaded after using etripamil.
• Do not use more than 2 doses within a 24-hour period.

If you do not receive the full first dose (1 spray in each nostril) because the device did not work or was used incorrectly, wait at least 10 minutes before giving a second dose, if needed.

Call your doctor if your symptoms do not improve within 20 minutes after giving the second dose. If fainting occurs, caregivers should place you on your back and seek medical help.

Each nasal spray pump is for one use only. Throw it away after one use, even if there is still medicine left inside.

Store at room temperature away from moisture and heat. Do not use etripamil nasal if the expiration date on the label has passed.

You should not use etripamil if you have a serious heart condition such as heart failure (NYHA Class II to IV), "sick sinus syndrome" (unless you have a pacemaker), Wolff-Parkinson-White syndrome, Lown-Ganong-Levine syndrome, or second- or higher-degree AV block.

You should not use etripamil if you are allergic to it, or if you have:

• heart failure;
• "sick sinus syndrome" or "AV block" (unless you have a pacemaker); or
• certain heart rhythm disorders (such as Wolff-Parkinson-White syndrome, Lown-Ganong-Levine syndrome, or an abnormal heart rhythm pattern called pre-excitation (delta wave) on an electrocardiogram (ECG)).

Tell your doctor if you have or have ever had:

• history of fainting; or
• low blood pressure.

It is not known if etripamil will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Do not breastfeed within 12 hours after using etripamil. If you use a breast pump during this time, throw out the milk and do not feed it to your baby.

Get emergency medical help if you notice signs of an allergic reaction: hives, trouble breathing, or swelling of your face, lips, tongue, or throat.

Etripamil nasal may cause serious side effects. Contact your doctor immediately if you experience:

• dizziness; or
• fainting.

Common side effects of etripamil nasal may include:

• runny or stuffy nose;
• throat irritation; or
• nosebleed.

This is not a complete list of side effects, and others may happen. Contact your doctor for medical advice regarding side effects. You can report side effects to the FDA at 1-800-FDA-1088.

Usual Adult Dose for Paroxysmal Supraventricular Tachycardia:

Initial dose: 1 spray in each nostril for a total dose 70 mgRepeat dose (if needed): If symptoms persist after 10 minutes, administer a second dose of 1 spray into each nostril (70 mg total)Maximum dose: 140 mg in a 24-hour periodComments:-This drug should be given as soon as possible after onset of paroxysmal supraventricular tachycardia (PSVT).-One device contains 2 sprays delivering 70 mg total; a second device is required for additional doses.Use: For the conversion of acute symptomatic episodes of PSVT to sinus rhythm

Etripamil is used as needed and does not have a daily dose. Do not use two doses at the same time.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Do not share etripamil nasal with another person, even if they have the same symptoms you have.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Other drugs may affect etripamil, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you are using.