Euflexxa (injection)

Euflexxa is similar to the fluid that is found around your joints. This fluid helps lubricate and cushion the joints.

Euflexxa is used to relieve knee pain caused by osteoarthritis.

Euflexxa is generally given when other arthritis medications have not worked.

Euflexxa may also be used for other reasons that are not mentioned in this medication guide.

You should not receive a Euflexxa if you have an infection in your knee or in the skin around your knee.

You should not receive Euflexxa if you are allergic to it, or if you have an infection in your knee or the skin around your knee.

Euflexxa is not approved for use by anyone younger than 21 years old.

Tell your doctor if you have ever had:

• blood clots or circulation problems in your legs; or
• an allergy to birds, feathers, or egg products.

It is not known whether Euflexxa will harm an unborn baby. Tell your doctor if you are pregnant.

It may not be safe to breast-feed a baby while you are using this medicine. Ask your doctor about any risks.

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Euflexxa may cause serious side effects. Call your doctor right away if you have:

• severe pain or swelling around the knee after the injection.

Common side effects of Euflexxa may include:

• warmth, pain, redness, stiffness, bruising, or swelling where the medicine was injected;
• nausea, stomach pain;
• trouble walking;
• swelling in your hands or feet;
• back pain, joint pain, muscle pain;
• numbness or a tingling feeling;
• headache, dizziness; or
• runny or stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may happen. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Euflexxa is injected directly into your knee joint. A healthcare provider will give you this injection.

Euflexxa is usually given once every week for 3 to 5 weeks. Follow your doctor's dosing instructions very carefully.

To prevent pain and swelling, your doctor may recommend resting your knee or applying ice for a short time after your injection.

Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

Tell your doctor if your symptoms do not improve, or if they get worse.

Call your doctor for guidance if you miss your appointment for Euflexxa.

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to happen.

For at least 48 hours after your injection, do not jog, do strenuous activities, or play high-impact sports like soccer or tennis. Also, do not engage in weight-bearing activities or stand for more than 1 hour at a time. Ask your doctor how long to wait before you can return to these activities.

Other drugs may impact Euflexxa, including prescription and over-the-counter medicines, vitamins, and herbal products. Inform your doctor about all the medicines you are currently taking and any new medicine you begin or stop using.