Excedrin PM Express

Acetaminophen is a pain reliever and a fever reducer. Diphenhydramine is an antihistamine.

Excedrin PM Express is a combination medicine used to treat occasional sleeplessness related to minor aches and pains. Excedrin PM Express is not for use in treating sleeplessness without pain, or sleep problems that happen frequently.

Excedrin PM Express is also used to treat minor aches and pains such as headache, back pain, joint or muscle pain, tooth pain, or menstrual cramps.

Excedrin PM Express is also used to treat runny nose, sneezing, itchy nose and throat, and pain or fever caused by allergies, the common cold, or the flu.

Excedrin PM Express may also be used for purposes not listed in this medication guide.

Use exactly as directed on the label, or as prescribed by your doctor. Excedrin PM Express is only for short-term use until your symptoms go away.

Do not take more of Excedrin PM Express than is recommended. An overdose of acetaminophen can harm your liver or cause death. Taking too much diphenhydramine can lead to serious heart issues, seizures, coma, or death.

Excedrin PM Express is not for anyone younger than 12 years old. Do not use this medicine to make a child sleepy. Misusing antihistamines in very young children can lead to death.

Do not use this medicine for longer than 2 weeks to treat sleep issues, or longer than 7 days to treat cold or allergy symptoms.

Call your doctor if you still have a fever after 3 days, or if you still have pain after 10 days (or 5 days if you are 12-17 years old). Also call your doctor if your symptoms get worse, or if you notice any redness or swelling.

If you need surgery or medical tests, inform the doctor ahead of time if you have taken this medicine in the past few days.

Store at room temperature, away from moisture and heat.

Use Excedrin PM Express exactly as directed. Taking too much acetaminophen can harm your liver or lead to death. Taking too much diphenhydramine can cause serious heart issues, seizures, coma, or death.

Do not use this medicine to make a child sleepy. This medicine is not for anyone younger than 12 years old.

Ask a doctor or pharmacist before using any other medicine that may have acetaminophen or diphenhydramine. Taking too much of either can lead to a deadly overdose.

Drinking alcohol may raise your risk of liver damage while using acetaminophen.

Stop using this medicine and call your doctor immediately if you notice skin redness or a rash that spreads and causes blistering and peeling.

Ask a doctor before taking medicine that contains acetaminophen if you have ever had liver disease, or if you drink more than 3 alcoholic beverages per day.

Ask a doctor or pharmacist if this medicine is safe to use if you have ever had:

• liver disease;
• an enlarged prostate or problems with urination;
• asthma, chronic obstructive pulmonary disease (COPD), emphysema, or any other breathing problem;
• glaucoma; or
• a condition for which you take warfarin (Coumadin, Jantoven).

Ask a doctor before using this medicine if you are pregnant or breastfeeding. Diphenhydramine may slow down breast milk production.

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This can happen even if you have taken acetaminophen before and had no reaction. Stop taking this medicine and call your doctor right away if you notice skin redness or a rash that spreads and causes blistering and peeling. If you have this type of reaction, you should never take any medicine that contains acetaminophen again.

The medicine may cause serious side effects. Stop using the medicine and call your doctor immediately if you experience:

• severe drowsiness;
• painful or difficult urination; or
• liver problems—loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects of Excedrin PM Express may include:

• drowsiness;
• constipation;
• decreased urination;
• dry eyes, blurred vision; or
• dry mouth, nose, or throat.

This is not a complete list of side effects, and others may occur. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Since Excedrin PM Express is taken as needed, you might not follow a specific dosing schedule. If you miss a dose and it’s almost time for your next dose, just skip the missed dose. Do not take two doses at the same time.

Seek emergency medical help or call the Poison Help line at 1-800-222-1222. Taking too much can be deadly or harm your liver.

Signs of an overdose may include loss of appetite, vomiting, weakness, confusion, ringing in your ears, pain in the upper stomach, dark urine, no urination, very dry eyes and mouth, yellowing of your skin or eyes, dilated pupils, fast heartbeats, tremors, agitation, hallucinations, or seizures.

Avoid driving or doing anything dangerous until you know how Excedrin PM Express affects you. Your reactions may be affected.

Check with a doctor or pharmacist before using any other medicine that might have acetaminophen or diphenhydramine. This includes medicines for pain, fever, swelling, cold or flu symptoms, or anti-itch creams. Taking too much acetaminophen or diphenhydramine can cause a deadly overdose.

Drinking alcohol may raise your risk of liver damage when taking acetaminophen.

Ask a doctor or pharmacist before using Excedrin PM Express with any other medicines, especially those that can cause drowsiness (such as opioid medication, sleep medicine, a muscle relaxer, or medicine for anxiety or seizures). Inform your doctor about all your current medicines and any medicine you begin or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.