Focinvez

Focinvez is used with other medications to stop nausea and vomiting that may happen after chemotherapy in adults and children who are at least 6 months old and weigh at least 6 kg (13 pounds).

Focinvez is not used to treat nausea and vomiting that you already have.

Focinvez may also be used for other reasons not mentioned in this medication guide.

Tell your doctor about all your other medicines. Some drugs should not be used with Focinvez.

You should not use Focinvez if you are allergic to Focinvez or similar medicines like aprepitant.

Some drugs should not be used with Focinvez. Your treatment plan may change if you also use pimozide.

Tell your doctor if you have ever had:

• to use a blood thinner (or a medicine called warfarin) and you have routine "INR" or prothrombin time tests; or
• liver disease.

It is not known if Focinvez will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Ask a doctor if it is safe to breastfeed while using this medicine.

Focinvez can make hormonal birth control less effective, including birth control pills, injections, implants, skin patches, and vaginal rings. Use barrier birth control to prevent pregnancy: condom, diaphragm, cervical cap, or contraceptive sponge.

Ask your doctor about the best form of birth control while you are using Focinvez. Keep using the barrier form of birth control for 1 month after your last dose.

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Some side effects may happen during the injection. Tell your medical caregiver if you feel dizzy, nauseated, light-headed, itchy, sweaty, or have a headache, chest tightness, back pain, trouble breathing, or swelling in your face.

Focinvez may cause serious side effects. Call your doctor right away if you have:

• pain, redness, swelling, burning, blistering, or skin changes where the medicine was injected; or
• a light-headed feeling, as if you might pass out; or
• fast or slow heart rate.

Common side effects of Focinvez may include:

• feeling weak or tired;
• fever;
• low blood cell counts;
• urinary tract infection;
• stomach pain or upset;
• diarrhea; or
• pain, weakness, or numbness in your arms or legs.

This is not a complete list of side effects, and others may occur. Call your doctor for medical advice about side effects. You can report side effects to the FDA at 1-800-FDA-1088.

Focinvez is given as an infusion into a vein. A healthcare provider will give you this injection.

Focinvez is not for long-term use.

Focinvez is usually given on the first day of chemotherapy treatment.

Tell your medical caregivers if you feel any burning or pain when Focinvez is injected.

You may be given other medications to further help prevent nausea and vomiting.

You may need blood tests after receiving Focinvez if you also take a blood thinner called warfarin.

In a medical setting, it is unlikely that you will miss a dose of Focinvez.

In a medical setting, an overdose would be treated right away.

Follow your doctor's instructions about any limits on food, drinks, or activities.

Sometimes it is not safe to use certain medicines together. Some drugs can change the levels of other drugs in your blood, which may increase side effects or make the medicines work less effectively.

Many drugs can affect Focinvez. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

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