Fosaprepitant

Fosaprepitant is used along with other medications to stop nausea and vomiting that may happen due to chemotherapy in adults and children who are at least 6 months old and weigh at least 6 kg (13 pounds).

Fosaprepitant is not used to treat nausea and vomiting that you already have.

Fosaprepitant may also be used for other reasons not mentioned in this medication guide.

Tell your doctor about all the other medicines you are taking. Some drugs should not be used with fosaprepitant.

You should not use fosaprepitant if you are allergic to fosaprepitant or similar medicines such as aprepitant.

Some drugs should not be used with fosaprepitant. Your treatment plan may change if you also use pimozide.

Tell your doctor if you have ever had:

• to use a blood thinner (or a medicine called warfarin) and you have routine "INR" or prothrombin time tests; or
• liver disease.

It is not known if fosaprepitant will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Ask a doctor if it is safe to breastfeed while using this medicine.

Fosaprepitant can make hormonal birth control less effective, including birth control pills, injections, implants, skin patches, and vaginal rings. Use barrier birth control to prevent pregnancy: condom, diaphragm, cervical cap, or contraceptive sponge.

Ask your doctor about the best form of birth control while you are using fosaprepitant. Keep using the barrier form of birth control for 1 month after your last dose.

Get emergency medical help if you have signs of an allergic reaction: hives, difficulty breathing, swelling of your face, lips, tongue, or throat.

Some side effects may occur during the injection. Tell your medical caregiver if you feel dizzy, nauseated, light-headed, itchy, sweaty, or have a headache, chest tightness, back pain, trouble breathing, or swelling in your face.

Fosaprepitant may cause serious side effects. Call your doctor at once if you have:

• pain, redness, swelling, burning, blistering, or skin changes where the medicine was injected; or
• a light-headed feeling, like you might pass out; or
• fast or slow heart rate.

Common side effects of fosaprepitant may include:

• feeling weak or tired;
• fever;
• low blood cell counts;
• urinary tract infection;
• stomach pain or upset;
• diarrhea; or
• pain, weakness, or numbness in your arms or legs.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Fosaprepitant is given as an infusion into a vein. A healthcare provider will give you this injection.

Fosaprepitant is not for long-term use.

Fosaprepitant is usually given on the first day of chemotherapy treatment.

Tell your medical caregivers if you feel any burning or pain when fosaprepitant is injected.

You may be given other medications to further help prevent nausea and vomiting.

You may need blood tests after receiving fosaprepitant if you also take a blood thinner called warfarin.

In a medical setting, it is unlikely that you will miss a dose of fosaprepitant.

In a medical setting, an overdose would be treated quickly.

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Sometimes it is not safe to use certain medicines together. Some drugs can change the levels of other drugs in your blood, which may increase side effects or make the medicines less effective.

Many drugs can affect fosaprepitant. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you begin or stop using.

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