Fostamatinib

Fostamatinib is used to treat chronic immune thrombocytopenia, which is a bleeding condition due to low platelet levels in the blood. fostamatinib is given when other treatments have not worked.

Fostamatinib may also be used for reasons not mentioned in this medication guide.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

You may take fostamatinib with or without food.

Fostamatinib can cause diarrhea. You may need to change your diet, drink extra fluids, or take anti-diarrhea medication. Follow your doctor's instructions for treating or preventing diarrhea.

Fostamatinib can raise your blood pressure, sometimes to dangerous levels. Your blood pressure will need to be checked often.

You will also need frequent medical tests. Your doctor may change your dose, or you may need to stop using fostamatinib based on test results.

Store at room temperature away from moisture and heat. Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative.

Fostamatinib can increase your blood pressure, occasionally to harmful levels. Fostamatinib may also lead to liver issues, severe diarrhea, and infections.

Contact your doctor if you experience: headaches, chest pain, shortness of breath, severe diarrhea, stomach pain, fever, or sore throat.

Fostamatinib is not approved for anyone younger than 18 years old.

Tell your doctor if you have ever had:

• high blood pressure; or
• liver problems.

Do not use fostamatinib if you are pregnant. It could harm the unborn baby. Use effective birth control to prevent pregnancy while using fostamatinib and for at least 1 month after your last dose.

Do not breast-feed while using this medicine, and for at least 1 month after your last dose.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Fostamatinib may cause serious side effects. Call your doctor right away if you have:

• severe diarrhea;
• stomach pain (upper right side);
• dark urine, jaundice (yellowing of the skin or eyes);
• headaches, chest pain, shortness of breath; or
• fever, sore throat, or other signs of infection.

Your fostamatinib doses may be delayed or permanently stopped if you have certain side effects.

Common side effects of fostamatinib may include:

• increased blood pressure;
• diarrhea, nausea, stomach pain;
• abnormal liver function tests;
• chest pain;
• dizziness, tiredness;
• rash; or
• cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Usual Adult Dose for Thrombocytopenia:

100 mg orally 2 times a day; after a month, if platelet count has not increased to at least 50 x 10(9)/L, increase to 150 mg orally 2 times a dayComments:-This drug may be taken with or without food. -In the case of a missed dose, instruct patients to take their next dose at its regularly scheduled time.-Use the lowest dose to achieve and maintain a platelet count at least 50 x 10(9)/L to reduce the risk of bleeding.Use: For the treatment of thrombocytopenia in adult patients with chronic immune thrombocytopenia (ITP) who have had an insufficient response to a previous treatment

Skip the missed dose and take your next dose at the usual time. Do not take two doses at once.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Other drugs may affect fostamatinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.