Glycopyrrolate and neostigmine

Glycopyrrolate and neostigmine is used in adults and children who are at least 2 years old to help restore muscle function after surgery.

Glycopyrrolate and neostigmine may also be used for reasons not mentioned in this medication guide.

Tell your doctor if you take other medicines or have any medical conditions or allergies.

You should not use glycopyrrolate and neostigmine if you are allergic to it, or if you have:

• peritonitis (inflammation of the membrane lining the organs inside your abdomen);
• a stomach or bowel obstruction (including paralytic ileus);
• severe ulcerative colitis, toxic megacolon;
• a bladder obstruction or other urination problems;
• glaucoma;
• myasthenia gravis; or
• active bleeding with heart and blood circulation problems.

Tell your doctor if you have or have ever had:

• heart problems or a heart rhythm disorder;
• high blood pressure;
• a thyroid disorder;
• colostomy or ileostomy; or
• liver or kidney disease.

Tell your doctor if you are pregnant or breastfeeding.

Get emergency medical help if you have signs of an allergic reaction: hives, difficulty breathing, swelling of your face, lips, tongue, or throat.

Glycopyrrolate and neostigmine may cause serious side effects. Call your doctor right away if you experience:

• severe constipation, severe stomach pain and bloating;
• diarrhea (especially if you have a colostomy or ileostomy);
• painful or difficult urination;
• fast or pounding heartbeats, fluttering in your chest;
• confusion, severe drowsiness;
• fever, shallow breathing, weak pulse, hot and red skin; or
• eye pain, seeing halos around lights.

Common side effects of glycopyrrolate and neostigmine may include:

• nausea, vomiting;
• dry mouth;
• difficulty urinating or urination problems;
• blurred vision, light sensitivity;
• decreased sweating; or
• slow or fast heartbeats, fluttering in your chest.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Follow all directions on your prescription label and read all medication guides or instruction sheets.

Glycopyrrolate and neostigmine is injected into a vein by a healthcare provider over a period of at least 1 minute.

Glycopyrrolate and neostigmine is used as a single dose and does not have a daily dosing schedule.

In a medical setting, an overdose will be treated quickly.

Do not drive or engage in hazardous activities until you understand how glycopyrrolate and neostigmine will affect you. Your reactions may be impaired.

Do not become overheated or dehydrated during exercise or in hot weather. Glycopyrrolate and neostigmine can reduce sweating, and you may be more likely to experience heat stroke.

Sometimes it is not safe to use certain medicines together. Some drugs can change the levels of other drugs in your blood, which may increase side effects or make the medicines less effective.

Tell your doctor about all your other medicines, especially:

• medicine to treat depression, anxiety, mood disorders, or mental illness;
• bronchodilator asthma medication;
• cold or allergy medicine (Benadryl and others);
• medicine to treat overactive bladder;
• medicine to treat Parkinson's disease; or
• medicine to treat stomach problems, motion sickness, or irritable bowel syndrome.

This list is not complete and many other drugs may affect glycopyrrolate and neostigmine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.