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Bacterial vaccines intramuscular powder for injection (-)

Haemophilus b conjugate (PRP-T) vaccine

Generic name: haemophilus b conjugate (PRP-T) vaccine

Brand names: ActHIB (Hib), Hiberix (Hib)

Last updated November 2, 2026 0 views
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What is haemophilus b conjugate (PRP-T) vaccine?

Haemophilus influenzae type B (Hib) is a type of bacteria that can lead to serious health issues, such as breathing problems or meningitis. Hib infection mostly impacts children and can be deadly.

Haemophilus b conjugate (PRP-T) vaccine is used to prevent this illness in children and is sometimes given with other vaccines to protect against additional diseases.

ActHIB is administered to children aged 2 months to 5 years old. Hiberix is given to children aged 6 weeks to 4 years old (before their fifth birthday).

The vaccine works by introducing a small amount of the bacteria or a protein from the bacteria to your child, prompting the body to build immunity to the disease. This vaccine will not treat an active infection that is already present and will not guard against other types of influenza.

Like any vaccine, the haemophilus b conjugate vaccine may not protect every person from the disease.

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How should I receive this vaccine?

This vaccine is injected into a muscle. Your child will receive this injection in a doctor's office or clinic.

This vaccine is given in a series of shots. The first shot is usually given when the child is 2 months old. The other shots are given at 4 months and 6 months of age. The booster shot is given at 15 to 18 months of age. The first shot may be given as early as 6 weeks of age.

Your child's individual booster schedule may be different from these guidelines, especially if the child does not start this series of shots before 7 months of age. Follow your doctor's instructions or the schedule recommended by the health department of the state you live in.

Your doctor may recommend treating fever and pain with an aspirin free pain reliever such as acetaminophen (Tylenol) or ibuprofen (Motrin, Advil, and others) when the shot is given and for the next 24 hours. Follow the label directions or your doctor's instructions about how much of haemophilus b conjugate (PRP-T) vaccine to give your child.

It is especially important to prevent fever from occurring in a child who has a seizure disorder such as epilepsy.

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Warnings

Tell your doctor if your child takes any other medicines, has other medical conditions, or has allergies.

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Before taking this medicine

Your child should not receive this vaccine if he or she has ever had an allergic reaction to a haemophilus B, tetanus, or meningococcal vaccine.

If your child has any of these other conditions, this vaccine may need to be postponed or not given at all:

  • severe immune suppression caused by disease (such as cancer, HIV, or AIDS), or by receiving certain medicines such as steroids, chemotherapy or radiation; or
  • a history of seizures.

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This vaccine side effects

Get emergency medical help if your child shows signs of an allergic reaction: hives; difficulty breathing; swelling of the face, lips, tongue, or throat.

Keep track of all side effects your child experiences after receiving this vaccine. When the child gets a booster dose, inform the doctor if the previous shot caused any side effects.

Call your doctor immediately if your child has:

  • a seizure;
  • fussiness, irritability, or crying for an hour or longer; or
  • high fever (within a few hours or a few days after the vaccine).

Common side effects of haemophilus b conjugate (PRP-T) vaccine may include:

  • fever;
  • fussiness, irritability, crying;
  • drowsiness;
  • loss of appetite; or
  • pain, swelling, or redness at the injection site.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report vaccine side effects to the US Department of Health and Human Services at 1-800-822-7967.

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Haemophilus b conjugate (PRP-T) vaccine dosing information

Usual Pediatric Dose for Haemophilus influenzae Prophylaxis:

2 months to 5 years:4 dose series:3 primary doses of 0.5 mL, IM, at 2, 4 and 6 months of age1 booster dose of 0.5 mL, IM, at 15 to 18 months of age

What happens if I miss a dose?

Contact your doctor if you miss a booster dose or fall behind schedule. The next dose should be given as soon as possible. You do not need to start over.

Make sure your child gets all recommended doses of this vaccine. If your child does not receive the full series of vaccines, he or she may not be fully protected against the disease.

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What happens if I overdose?

An overdose of this vaccine is not likely to happen.

Follow your doctor's instructions about any restrictions on food, drinks, or activities.

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What other drugs will affect this vaccine?

Before your child gets this vaccine, inform the vaccination provider about all other vaccines your child has had.

Also, let the vaccination provider know if your child has recently taken any drugs or treatments that can weaken the immune system, such as:

  • steroid medicine;
  • cancer treatments;
  • medicine for psoriasis, rheumatoid arthritis, or other autoimmune disorders; or
  • medicines for preventing organ transplant rejection.

If your child is taking any of these medications, he or she may not be able to receive the vaccine or may need to wait until the other treatments are completed.

This list does not include everything. Other medications may impact this vaccine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are mentioned here.

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Related medicines

Before you take this medicine: the information on this page is general and may not cover your personal circumstances. Read the label supplied with your medicine and ask a pharmacist or doctor if you are unsure, especially if you are pregnant, breastfeeding, taking other medicines or managing a long-term condition.
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Content is provided for education and is not medical advice. See our medical disclaimer.