Humatin (Oral)

Paromomycin is used to treat acute and chronic intestinal amebiasis (a bowel infection caused by a parasite in your stomach or bowels). It is also used with other medicines to help reduce the symptoms of hepatic coma (a complication of liver disease).

Paromomycin belongs to a group of medicines called aminoglycoside antibiotics. It works by killing bacteria or stopping their growth. However, this medicine will not work for colds, flu, or other viral infections.

This medicine is available only with your doctor's prescription.

It is very important that your doctor checks how you or your child are doing at regular visits to ensure that this medicine is working properly.

If you or your child's symptoms do not get better within a few days, or if they get worse, contact your doctor.

In deciding to use a medicine, you need to think about the risks and benefits of taking it. This is a choice you will make with your doctor. For this medicine, consider the following:

Allergies

Inform your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also, tell your healthcare professional if you have any other allergies, such as to foods, dyes, preservatives, or animals. For over-the-counter products, read the label or package ingredients carefully.

Pediatric

Studies done so far have not shown any specific problems that would limit the use of paromomycin for treating intestinal amebiasis in children. However, the safety and effectiveness of paromomycin for treating hepatic coma in children have not been established.

Geriatric

There is no information available regarding how age affects the effects of paromomycin in older patients.

Breast Feeding

There are no adequate studies in women to determine the risk to infants when using this medication while breastfeeding. Weigh the potential benefits against the potential risks before taking this medication during breastfeeding.

Interactions with Medicines

Some medicines should not be used together at all, while others may be used together even if they could interact. In such cases, your doctor may adjust the dose or take other precautions. When taking this medicine, it is especially important for your healthcare professional to know if you are using any of the medicines listed below. The following interactions have been selected based on their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be necessary in some cases. If both medicines are prescribed together, your doctor may change the dose or frequency of use for one or both of the medicines.

• Aspirin
• Cholera Vaccine, Live
• Colistimethate Sodium
• Emtricitabine
• Foscarnet
• Furosemide
• Methotrexate
• Tacrolimus
• Tenofovir Alafenamide

Using this medicine with any of the following medicines may increase the risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or frequency of use for one or both of the medicines.

• Semaglutide

Interactions with Food/Tobacco/Alcohol

Some medicines should not be taken around the time of eating food or specific types of food due to possible interactions. Using alcohol or tobacco with certain medicines may also lead to interactions. Discuss with your healthcare professional how to use your medicine in relation to food, alcohol, or tobacco.

Other Medical Problems

Having other medical problems may affect how this medicine works for you. Make sure to tell your doctor if you have any other medical issues, especially:

• Bowel blockage—Should not be used in patients with this condition.

• Stomach or bowel problems (e.g., lesions, ulcerations)—Use with caution. May increase the risk of more serious side effects.

Along with its necessary effects, a medicine may cause some unwanted effects. While not all of these side effects may happen, if they do occur, they may require medical attention.

Some side effects may happen that usually do not need medical attention. These side effects may go away during treatment as your body gets used to the medicine. Additionally, your health care professional may be able to provide ways to prevent or lessen some of these side effects. Check with your health care professional if any of the following side effects continue, become bothersome, or if you have any questions about them:

Incidence not known

• Abdominal or stomach cramps
• diarrhea
• nausea

Other side effects not listed may also occur in some patients. If you notice any other effects, contact your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Humatin

Available Dosage Forms:

• Capsule

Therapeutic Class: Antibiotic

Chemical Class: Aminoglycoside

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

It is best to take this medicine with food.

To help clear up your infection completely, keep using this medicine for the full time of treatment, even if you begin to feel better after a few days. Also, this medicine works best when there is a constant amount in the blood. To help keep the amount constant, you must take this medicine on a regular schedule.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (capsules): For intestinal amebiasis:Adults and children—Dose is based on body weight and must be determined by your doctor. The dose is usually 25 to 35 milligrams (mg) per kilogram (kg) of body weight, divided in three doses, for 5 to 10 days. For management of hepatic coma: Adults—4000 milligrams (mg) per day, divided in small doses, for 5 to 6 days. Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.