Hyaluronidase (injection)

Hyaluronidase is a protein that has been genetically designed.

Hyaluronidase is used along with fluids injected into the body to treat dehydration. Hyaluronidase can also help your body absorb other medications that are injected.

Hyaluronidase is also used to help contrast dyes in your body appear more clearly on certain types of x-rays or scans.

Hyaluronidase may also be used for reasons not mentioned in this medication guide.

Serious drug interactions can happen when some medicines are taken with hyaluronidase. Inform your doctor about all the medicines you are currently using.

You should not receive hyaluronidase if you are allergic to it.

Your doctor may do a skin test to check for an allergy to hyaluronidase before you get the medication.

Some medicines can cause harmful or serious effects when taken with hyaluronidase. Your doctor may adjust your treatment plan if you also take:

• furosemide (Lasix);
• phenytoin (Dilantin);
• a sedative or anxiety medication (such as diazepam, lorazepam, alprazolam, Valium, Xanax, Ativan, Tranxene, and others);
• aspirin or salicylates;
• cortisone or ACTH (Corticotropin);
• estrogens; or
• an antihistamine (such as a cold or allergy medicine).

Tell your doctor if you are pregnant.

It may not be safe to breast-feed while using hyaluronidase. Ask your doctor about any risks.

Get emergency medical help if you notice signs of an allergic reaction: hives; trouble breathing; swelling of your face, lips, tongue, or throat.

Hyaluronidase may lead to serious side effects. Contact your doctor immediately if you experience:

• swelling in your hands, feet, or other areas of your body; or
• pain, swelling, itching, or redness at the injection site.

This is not a complete list of side effects, and others may happen. Contact your doctor for medical advice about side effects. You can report side effects to the FDA at 1-800-FDA-1088.

Hyaluronidase is injected under the skin, into a muscle, or into other tissues of the body.

A healthcare provider will give you this injection.

Hyaluronidase should not be injected into a vein (as an intravenous injection).

Since you will get hyaluronidase (injection) in a clinical setting, it is unlikely that you will miss a dose.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Follow your doctor's instructions about any limits on food, drinks, or activities.

Other drugs may impact hyaluronidase, including prescription and over-the-counter medicines, vitamins, and herbal products. Inform your doctor about all your current medicines and any medicine you begin or discontinue using.

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