Hylenex (injection)

Hyaluronidase is a protein that has been genetically designed.

Hyaluronidase is used along with fluids injected into the body to treat dehydration. It can also help your body absorb other injected medications.

Hyaluronidase is used to make contrast dyes in your body appear more clearly on certain types of x-rays or scans.

Hyaluronidase may also be used for other purposes not listed in this medication guide.

Serious drug interactions can happen when some medicines are used with hyaluronidase. Inform your doctor about all the medicines you are currently taking.

You should not receive hyaluronidase if you are allergic to it.

Your doctor may do a skin test to check for an allergy to hyaluronidase before you get the medication.

Some medicines can cause unwanted or dangerous effects when taken with hyaluronidase. Your doctor may change your treatment plan if you also take:

• furosemide (Lasix);
• phenytoin (Dilantin);
• a sedative or anxiety medication (such as diazepam, lorazepam, alprazolam, Valium, Xanax, Ativan, Tranxene, and others);
• aspirin or salicylates;
• cortisone or ACTH (Corticotropin);
• estrogens; or
• an antihistamine (such as a cold or allergy medicine).

Tell your doctor if you are pregnant.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risks.

Get emergency medical help if you notice signs of an allergic reaction: hives; trouble breathing; swelling of your face, lips, tongue, or throat.

Hylenex may lead to serious side effects. Contact your doctor immediately if you experience:

• swelling in your hands, feet, or other parts of your body; or
• pain, swelling, itching, or redness at the injection site.

This is not a full list of side effects, and others may happen. Reach out to your doctor for medical advice about side effects. You can report side effects to the FDA at 1-800-FDA-1088.

Hyaluronidase is injected under the skin, into a muscle, or into other tissues of the body.

A healthcare provider will give you this injection.

Hyaluronidase should not be injected into a vein (as an intravenous injection).

Because you will receive hyaluronidase in a clinical setting, it is unlikely that you will miss a dose.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Other drugs may affect hyaluronidase, including prescription and over-the-counter medicines, vitamins, and herbal products. Inform your doctor about all your current medicines and any medicine you begin or stop using.

Find detailed information on biosimilars for this medication.

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