Hyzine (Intramuscular)

Hydroxyzine injection is used to help control anxiety and tension caused by dental, nervous, and emotional issues. It can also help manage anxiety and promote sleep before and after surgery. This medicine is also used to relieve symptoms of an allergic reaction (for example, hives and itching skin) caused by asthma and chronic urticaria.

Hydroxyzine is an antihistamine. It works by blocking the effects of a substance called histamine, which the body makes. This medicine is also used to manage anxiety withdrawal symptoms in patients with alcohol dependence. It is also used to control nausea and vomiting symptoms and relieve anxiety in patients with certain heart conditions.

This medicine must be given by or under the supervision of your doctor.

Your doctor will monitor your progress closely while you or your child is taking this medicine. This will help your doctor determine if the medicine is working well and if treatment should continue.

Make sure your doctor knows if you are pregnant. Do not use this medicine in the early stages of pregnancy unless your doctor advises you to.

This medicine may cause a permanent depression (necrosis) under the skin at the injection site. Inform your doctor immediately if you notice any of these side effects at the injection site: depressed or indented skin, blue-green to black skin discoloration, or pain, redness, or sloughing (peeling) of the skin.

This medicine will enhance the effects of alcohol and other CNS depressants (medications that cause drowsiness or reduce alertness). Some examples of CNS depressants include antihistamines or medications for allergies or colds, sedatives, tranquilizers or sleeping medications, prescription pain medications or narcotics, medications for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics. Consult your doctor before taking any of the above while you or your child is using this medicine.

This medicine may cause dizziness or drowsiness. Do not drive or perform any activities that could be dangerous until you know how this medicine affects you.

Notify your doctor immediately if you or your child experience any changes in heart rhythm. You may feel dizzy or faint, or you may have a fast, pounding, or irregular heartbeat. Ensure your doctor is aware if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation.

Do not take other medications unless you have discussed them with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medications and herbal or vitamin supplements.

In deciding to use a medication, the chances of using the medication must be weighed against the good it will do. This is a decision you and your physician will make. For this medication, the following should be considered:

Allergies

Inform your doctor if you have ever had any unusual or allergic reaction to this drug or any other medicines. Additionally tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of hydroxyzine injection in children.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of hydroxyzine injection in the elderly. Nevertheless, elderly patients are more likely to have unwanted side effects (such as confusion, drowsiness) and age-related liver, kidney, or heart issues, which may require caution and an adjustment in the dose for patients receiving hydroxyzine injection.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this drug during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medications

Although certain drugs should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your clinician may want to change the dose, or other precautions may be necessary. When you are receiving this medication, it is especially essential that your healthcare professional know if you are using any of the medications listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not advised. Your doctor may decide not to treat you with this medicine or change some of the other medicines you take.

• Bepridil
• Calcium Oxybate
• Cisapride
• Dronedarone
• Levoketoconazole
• Magnesium Oxybate
• Mesoridazine
• Pimozide
• Piperaquine
• Potassium Citrate
• Potassium Oxybate
• Saquinavir
• Sodium Oxybate
• Sparfloxacin
• Terfenadine
• Thioridazine
• Tranylcypromine
• Ziprasidone

Using this drug with any of the following medicines is usually not advised, but may be required in some cases. If both drugs are prescribed together, your doctor may change the dose or how frequently you use one or both of the drugs.

• Adagrasib
• Alfentanil
• Alfuzosin
• Alprazolam
• Amantadine
• Amiodarone
• Amisulpride
• Amitriptyline
• Anagrelide
• Apomorphine
• Aripiprazole
• Aripiprazole Lauroxil
• Arsenic Trioxide
• Asenapine
• Astemizole
• Atazanavir
• Azithromycin
• Bedaquiline
• Benzhydrocodone
• Bromazepam
• Bromopride
• Buprenorphine
• Bupropion
• Buserelin
• Butorphanol
• Cannabidiol
• Cannabis
• Carbinoxamine
• Ceritinib
• Cetirizine
• Chloroquine
• Chlorpromazine
• Ciprofloxacin
• Citalopram
• Clarithromycin
• Clofazimine
• Clomipramine
• Clonazepam
• Clothiapine
• Clozapine
• Codeine
• Crizotinib
• Cyclobenzaprine
• Dabrafenib
• Daridorexant
• Dasatinib
• Degarelix
• Delamanid
• Desipramine
• Deslorelin
• Deutetrabenazine
• Dexmedetomidine
• Dihydrocodeine
• Disopyramide
• Dofetilide
• Dolasetron
• Domperidone
• Doxepin
• Doxylamine
• Droperidol
• Ebastine
• Efavirenz
• Encorafenib
• Entrectinib
• Eribulin
• Erythromycin
• Escitalopram
• Esketamine
• Etrasimod
• Famotidine
• Felbamate
• Fentanyl
• Fexinidazole
• Fingolimod
• Flecainide
• Flibanserin
• Fluconazole
• Fluoxetine
• Formoterol
• Foscarnet
• Fosphenytoin
• Fostemsavir
• Gabapentin
• Gabapentin Enacarbil
• Galantamine
• Gatifloxacin
• Gemifloxacin
• Gepirone
• Glasdegib
• Glucagon
• Glycopyrrolate
• Glycopyrronium Tosylate
• Gonadorelin
• Goserelin
• Granisetron
• Halofantrine
• Haloperidol
• Histrelin
• Hydrocodone
• Hydromorphone
• Hydroquinidine
• Hydroxychloroquine
• Ibutilide
• Iloperidone
• Imipramine
• Inotuzumab Ozogamicin
• Itraconazole
• Ivabradine
• Ivosidenib
• Ketamine
• Ketoconazole
• Lacosamide
• Lapatinib
• Lefamulin
• Lemborexant
• Lenvatinib
• Leuprolide
• Levocetirizine
• Levofloxacin
• Levorphanol
• Lofexidine
• Loxapine
• Lumefantrine
• Macimorelin
• Meclizine
• Mefloquine
• Meperidine
• Methacholine
• Methadone
• Metoclopramide
• Metronidazole
• Midazolam
• Mifepristone
• Mirtazapine
• Mizolastine
• Mobocertinib
• Moricizine
• Morphine
• Morphine Sulfate Liposome
• Moxifloxacin
• Nafarelin
• Nalbuphine
• Nelfinavir
• Nilotinib
• Norfloxacin
• Octreotide
• Ofloxacin
• Olanzapine
• Ondansetron
• Osilodrostat
• Osimertinib
• Oxaliplatin
• Oxycodone
• Oxymorphone
• Ozanimod
• Pacritinib
• Paliperidone
• Panobinostat
• Papaverine
• Paroxetine
• Pasireotide
• Pazopanib
• Pentamidine
• Pentazocine
• Periciazine
• Perphenazine
• Phenobarbital
• Pimavanserin
• Pipamperone
• Pitolisant
• Ponesimod
• Posaconazole
• Pregabalin
• Primidone
• Probucol
• Procainamide
• Prochlorperazine
• Promethazine
• Propafenone
• Protriptyline
• Quetiapine
• Quinidine
• Quinine
• Quizartinib
• Ranolazine
• Relugolix
• Remifentanil
• Remimazolam
• Revefenacin
• Ribociclib
• Risperidone
• Ritonavir
• Ropeginterferon Alfa-2b-njft
• Scopolamine
• Secretin Human
• Selpercatinib
• Sertindole
• Sertraline
• Sevoflurane
• Siponimod
• Sodium Phosphate
• Sodium Phosphate, Dibasic
• Sodium Phosphate, Monobasic
• Solifenacin
• Sorafenib
• Sotalol
• Sufentanil
• Sulpiride
• Sunitinib
• Tacrolimus
• Tamoxifen
• Tapentadol
• Telaprevir
• Telavancin
• Telithromycin
• Tetrabenazine
• Tiotropium
• Tolterodine
• Topiramate
• Toremifene
• Tramadol
• Trazodone
• Triclabendazole
• Trimipramine
• Triptorelin
• Vandetanib
• Vardenafil
• Vemurafenib
• Venlafaxine
• Vilanterol
• Vinflunine
• Voclosporin
• Voriconazole
• Vorinostat
• Zolpidem
• Zuclopenthixol
• Zuranolone

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain drugs may also cause interactions to occur. Discuss with your healthcare professional the use of your drug with food, alcohol, or tobacco.

Other Medical Issues

The presence of other medical issues may affect the use of this drug. Make sure you tell your physician if you have any other medical issues, especially:

• Electrolyte imbalance or
• Heart attack or
• Heart disease or
• Heart failure, uncompensated or
• Heart rhythm problems (eg, long QT syndrome, slow heartbeat), family history of—Use with caution. May cause adverse effects to become worse.

• Heart rhythm problems (eg, prolonged QT interval)—Should not be used in patients with this condition.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Incidence not known

• Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
• blue-green to black skin discoloration
• pain, redness, or sloughing of skin at the injection site

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare

• Shakiness in the legs, arms, hands, or feet
• trembling or shaking of the hands or feet

Incidence not known

• Drowsiness
• dry mouth

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Hyzine
• Restall
• Vistacot
• Vistaril IM

Available Dosage Forms:

• Solution

Therapeutic Class: Respiratory Agent

Pharmacologic Class: Hydroxyzine

Chemical Class: Hydroxyzine

A nurse or other trained health professional will give you or your child this medicine in a hospital. This medicine is given as a shot into a muscle.

• Can you take hydroxyzine for anxiety and sleep?
• Can Hydroxyzine be Taken Long-term For Anxiety?
• How long does hydroxyzine last?
• Does Benadryl help with or cause anxiety?
• Hydroxyzine Pamoate vs HCl: What’s the difference?
• Is hydroxyzine a controlled substance or addictive?
• Hydroxyzine vs Benadryl: What’s the difference?
• Can dogs take hydroxyzine?
• Does hydroxyzine cause weight gain or loss?

View more FAQ