Inderal (Intravenous)

Propranolol injection is used to manage fast heartbeats and irregular heart rhythms.

This medicine is a beta-blocker. It works by changing how nerve impulses affect certain areas of the body, such as the heart. This leads to the heart beating slower and in a regular rhythm.

This medicine is available only with your doctor's prescription.

Your doctor will only give you a few doses of this medicine until your condition improves, and then you will be switched to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

In deciding to use a medicine, the risks of taking the medicine must be weighed against the benefits it will provide. This is a decision you and your doctor will make together. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also, inform your healthcare professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been done on the effects of propranolol injection in children. Safety and efficacy have not been established for this group.

Geriatric

Studies so far have not shown any specific problems for older adults that would limit the usefulness of propranolol injection. However, older patients are more likely to have age-related liver, kidney, or heart issues, which may require a dosage adjustment when receiving propranolol injection.

Breast Feeding

There are no adequate studies in women to determine the risk to infants when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

While some medicines should not be used together at all, in other cases, two different medicines can be used together even if an interaction might happen. In these situations, your doctor may want to adjust the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional knows if you are taking any of the medicines listed below. The following interactions have been chosen based on their potential importance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Rizatriptan
• Thioridazine

Using this medicine with any of the following medicines is usually not recommended, but may be necessary in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Abametapir
• Albuterol
• Bupivacaine
• Bupivacaine Liposome
• Bupropion
• Capmatinib
• Ceritinib
• Clonidine
• Crizotinib
• Darunavir
• Desvenlafaxine
• Diatrizoate
• Diltiazem
• Dronedarone
• Epinephrine
• Escitalopram
• Eslicarbazepine Acetate
• Fedratinib
• Fenoldopam
• Fexinidazole
• Fingolimod
• Fluoxetine
• Formoterol
• Haloperidol
• Indacaterol
• Iobenguane I 131
• Iohexol
• Lacosamide
• Lercanidipine
• Levalbuterol
• Lidocaine
• Mefloquine
• Mepivacaine
• Olodaterol
• Oxymetazoline
• Pixantrone
• Ponesimod
• Prilocaine
• Rivastigmine
• Salmeterol
• Simeprevir
• Siponimod
• Sparsentan
• Terbutaline
• Venlafaxine
• Verapamil
• Vilanterol
• Zileuton

Using this medicine with any of the following medicines may increase the risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acarbose
• Aceclofenac
• Acemetacin
• Acetyldigoxin
• Albiglutide
• Alfuzosin
• Alogliptin
• Amtolmetin Guacil
• Aspirin
• Bromfenac
• Bufexamac
• Bunazosin
• Canagliflozin
• Celecoxib
• Chlorpromazine
• Chlorpropamide
• Cholestyramine
• Choline Salicylate
• Cimetidine
• Clonixin
• Dapagliflozin
• Deslanoside
• Dexibuprofen
• Dexketoprofen
• Diclofenac
• Diflunisal
• Digitoxin
• Digoxin
• Dihydroergotamine
• Dipyrone
• Doxazosin
• Droxicam
• Dulaglutide
• Empagliflozin
• Ergotamine
• Ertugliflozin
• Etodolac
• Etofenamate
• Etoricoxib
• Exenatide
• Felbinac
• Fenoprofen
• Fepradinol
• Feprazone
• Flecainide
• Floctafenine
• Flufenamic Acid
• Flurbiprofen
• Fluvoxamine
• Glimepiride
• Glipizide
• Glyburide
• Ibuprofen
• Indomethacin
• Insulin Aspart, Recombinant
• Insulin Degludec
• Insulin Detemir
• Insulin Glargine, Recombinant
• Insulin Glulisine
• Insulin Human Inhaled
• Insulin Human Isophane (NPH)
• Insulin Human Regular
• Insulin Lispro, Recombinant
• Ketoprofen
• Ketorolac
• Linagliptin
• Liraglutide
• Lixisenatide
• Lornoxicam
• Loxoprofen
• Lumiracoxib
• Meclofenamate
• Mefenamic Acid
• Meloxicam
• Metformin
• Metildigoxin
• Miglitol
• Morniflumate
• Moxisylyte
• Nabumetone
• Naproxen
• Nateglinide
• Nepafenac
• Niflumic Acid
• Nimesulide
• Nimesulide Beta Cyclodextrin
• Oxaprozin
• Oxyphenbutazone
• Parecoxib
• Phenoxybenzamine
• Phentolamine
• Phenylbutazone
• Piketoprofen
• Pioglitazone
• Piroxicam
• Pramlintide
• Pranoprofen
• Prazosin
• Proglumetacin
• Propyphenazone
• Proquazone
• Quinidine
• Repaglinide
• Rifapentine
• Rofecoxib
• Rosiglitazone
• Salicylic Acid
• Salsalate
• Saxagliptin
• Sitagliptin
• Sodium Salicylate
• St John's Wort
• Sulindac
• Tamsulosin
• Tenoxicam
• Terazosin
• Tiaprofenic Acid
• Tolazamide
• Tolbutamide
• Tolfenamic Acid
• Tolmetin
• Trimazosin
• Urapidil
• Valdecoxib
• Vildagliptin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or certain types of food, as interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions. The following interactions have been chosen based on their potential importance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Tobacco

Other Medical Problems

Having other medical issues may affect how you can use this medicine. Make sure to tell your doctor if you have any other medical problems, especially:

• Angina (severe chest pain)—May cause chest pain if stopped too quickly.

• Asthma or
• Bradycardia (slow heartbeat) or
• Heart block or
• Heart failure—Should not be used in patients with these conditions.

• Diabetes or
• Hyperthyroidism (overactive thyroid) or
• Hypoglycemia (low blood sugar)—May hide some signs and symptoms of these conditions, such as a fast heartbeat.

• Kidney disease or
• Liver disease—Use with caution. The effects may be stronger because the body may remove the medicine more slowly.

• Lung disease (e.g., bronchitis, emphysema)—May cause difficulty breathing in patients with this condition.

• Wolff-Parkinson-White syndrome (rare heart condition)—May cause a very slow heartbeat in patients with this condition.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

• Blurred vision
• chest pain or discomfort
• confusion
• decreased urine output
• dilated neck veins
• dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
• extreme fatigue
• irregular breathing
• lightheadedness, dizziness, or fainting
• shortness of breath
• slow or irregular heartbeat
• sweating
• swelling of face, fingers, feet, or lower legs
• tightness in chest
• troubled breathing
• unusual tiredness or weakness
• weight gain
• wheezing

Rare

• Blisters, hives, or itching
• fever and chills
• general feeling of discomfort or illness
• hair loss
• headaches
• muscle or joint pain
• skin rash
• sore throat
• swollen glands

Incidence not determined

• Abdominal pain, usually after eating a meal
• abdominal tenderness
• black, tarry stools
• blood in urine
• bloody nose
• bloody stools
• body aches or pain
• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• congestion
• constipation
• cough
• decreased awareness or responsiveness
• diarrhea
• difficult or labored breathing
• dryness or soreness of throat
• general feeling of tiredness or weakness
• heavier menstrual periods
• hoarseness
• lower back or side pain
• mimicry of speech or movements
• mutism
• nausea
• negativism
• no blood pressure or pulse
• noisy breathing
• painful or difficult urination
• paleness or cold feeling in fingertips and toes
• peculiar postures or movements, mannerisms, or grimacing
• pinpoint red or purple spots on skin
• rectal bleeding
• reddened skin
• runny nose
• severe sleepiness
• sores on the skin
• sores, ulcers, or white spots on lips or in mouth
• stopping of heart
• tender, swollen glands in neck
• tingling or pain in fingers or toes when exposed to cold
• trouble in swallowing
• unconsciousness
• unusual bleeding or bruising
• voice changes
• vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare

• Decreased interest in sexual intercourse
• dry eyes
• inability to have or keep an erection
• loss in sexual ability, desire, drive, or performance
• pain of penis on erection
• skin irritation or rash, including rash that looks like psoriasis
• thinning of hair

Incidence not determined

• Confusion about identity, place, and time
• crying
• depersonalization
• disturbed color perception
• double vision
• dysphoria
• euphoria
• halos around lights
• loss of strength or energy
• loss of vision
• mental depression
• muscle weakness
• night blindness
• overbright appearance of lights
• paranoia
• quick to react or overreact emotionally
• rapidly changing moods
• seeing, hearing, or feeling things that are not there
• short-term memory loss
• sleeplessness
• trouble sleeping
• tunnel vision
• unable to sleep
• unusual drowsiness, dullness, or feeling of sluggishness
• vivid dreams

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Inderal

Available Dosage Forms:

• Solution

Therapeutic Class: Cardiovascular Agent

Pharmacologic Class: Beta-Adrenergic Blocker, Nonselective

A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins.

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