Jadelle (Intradermal)

Levonorgestrel implant is used to prevent pregnancy for up to 5 years. It works by stopping a woman's egg from fully developing each month. The egg can no longer accept sperm, which prevents fertilization (pregnancy).

This medicine is to be given only by or under the direct supervision of a trained healthcare professional.

It is very important that your doctor checks your progress at regular visits to ensure this medicine is working properly and does not cause unwanted effects.

Infection at the insertion site may occur after inserting and removing the implants. It is important to tell your doctor if you feel any pain, numbness, or tingling in your upper arm.

Call your doctor right away if you think you have become pregnant while using this medicine. You may have a higher risk of an ectopic pregnancy if you get pregnant while your implants are in place. An ectopic pregnancy can be serious and life-threatening. It can also cause problems that may make it harder for you to become pregnant in the future.

You could have less bleeding or even stop having periods by the end of the first year. Call your doctor if you notice a change from your regular bleeding pattern after having your implants for a while, such as more bleeding or if you miss a period (and you were having periods even with your implants).

This device will not protect you from getting HIV/AIDS, herpes, or other sexually transmitted diseases. Tell your doctor if you or your partner begin to have sexual intercourse with other people, or if you or your partner test positive for a sexually transmitted disease. If this is a concern for you, talk with your doctor.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

This medicine may cause changes in your blood sugar levels. Also, this medicine may hide signs of low blood sugar, such as a rapid pulse rate. Check with your doctor if you have these problems or if you notice a change in the results of your blood or urine sugar tests.

Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (e.g., St. John's wort) or vitamin supplements.

In deciding to use a medicine, you and your doctor must consider the risks of taking it against the benefits it may provide.

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also, let your healthcare professional know if you have any other allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies have not shown any specific problems for teenage females that would limit the usefulness of levonorgestrel implants. This medicine can be used for birth control in teenage females but is not recommended before menstruation starts.

Geriatric

No specific studies on the effects of levonorgestrel implant in elderly women have been done. This medicine is not recommended for elderly women.

Breast Feeding

There are no adequate studies in women to determine the risk to infants when using this medication while breastfeeding. Consider the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Some medicines should not be used together, while in other cases, two different medicines may be used together even if an interaction might happen. In these situations, your doctor may change the dose, or other precautions may be needed. It is very important that your healthcare professional knows if you are taking any of the medicines listed below. The following interactions are based on their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of your other medicines.

• Tranexamic Acid

Using this medicine with any of the following medicines is usually not recommended, but may be necessary in some situations. If both medicines are prescribed together, your doctor may adjust the dose or how often you use one or both.

• Amoxicillin
• Ampicillin
• Amprenavir
• Apalutamide
• Aprepitant
• Armodafinil
• Artemether
• Bacampicillin
• Belzutifan
• Betamethasone
• Bexarotene
• Bosentan
• Carbamazepine
• Carbenicillin
• Cefaclor
• Cefadroxil
• Cefdinir
• Cefditoren
• Cefixime
• Cefpodoxime
• Cefprozil
• Ceftazidime
• Ceftibuten
• Cefuroxime
• Cenobamate
• Ceritinib
• Clobazam
• Cloxacillin
• Colesevelam
• Cyclacillin
• Cyclosporine
• Dabrafenib
• Darunavir
• Dexamethasone
• Dicloxacillin
• Dipyrone
• Doxycycline
• Efavirenz
• Elagolix
• Elvitegravir
• Encorafenib
• Enzalutamide
• Eslicarbazepine Acetate
• Etravirine
• Fosamprenavir
• Fosaprepitant
• Fosphenytoin
• Griseofulvin
• Guar Gum
• Isotretinoin
• Ivosidenib
• Lesinurad
• Lixisenatide
• Lopinavir
• Lorlatinib
• Lumacaftor
• Mavacamten
• Meropenem
• Minocycline
• Mitapivat
• Mitotane
• Mobocertinib
• Modafinil
• Mycophenolate Mofetil
• Mycophenolic Acid
• Nafcillin
• Nelfinavir
• Nevirapine
• Octreotide
• Oxacillin
• Oxcarbazepine
• Oxytetracycline
• Penicillin G
• Penicillin G Procaine
• Penicillin V
• Phenobarbital
• Phenylbutazone
• Phenytoin
• Pitolisant
• Prednisolone
• Prednisone
• Primidone
• Red Clover
• Rifabutin
• Rifampin
• Rifapentine
• Ritonavir
• Rufinamide
• Secobarbital
• St John's Wort
• Sugammadex
• Sultamicillin
• Tazemetostat
• Telaprevir
• Telotristat Ethyl
• Tetracycline
• Theophylline
• Thioridazine
• Ticarcillin
• Tigecycline
• Tirzepatide
• Tizanidine
• Topiramate
• Ulipristal

Using this medicine with any of the following medicines may raise the risk of certain side effects, but combining both might be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both.

• Acitretin
• Amitriptyline
• Atazanavir
• Clomipramine
• Diazepam
• Doxepin
• Imipramine
• Lamotrigine
• Licorice
• Lorazepam
• Perampanel
• Selegiline
• Tacrine
• Temazepam
• Triazolam
• Troleandomycin
• Voriconazole
• Warfarin

Interactions with Food/Tobacco/Alcohol

Some medicines should not be taken around the time of eating certain foods, as interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions. The following interactions are based on their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following may increase the risk of certain side effects, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or provide special instructions about food, alcohol, or tobacco use.

• Caffeine

Other Medical Problems

Other medical issues may affect the use of this medicine. Make sure to inform your doctor if you have any other medical problems, especially:

• Abnormal or unusual vaginal bleeding or
• Blood clots (e.g., deep vein thrombosis, pulmonary embolism) or
• Breast cancer, known or suspected, or a history of or
• Liver disease, including tumors—Should not be used in patients with these conditions.

• Bleeding problems or
• Depression, history of or
• Diabetes or
• Heart attack, history of or
• Heart disease or
• Hyperlipidemia (high cholesterol or fats in the blood) or
• Hypertension (high blood pressure), severe or history of or
• Kidney disease or
• Migraine headaches, severe or
• Ovarian cysts or
• Stroke, history of—Use with caution. May worsen these conditions.

Along with its necessary effects, this medicine may cause some unwanted effects. Not all of these side effects may happen, but if they do, you may need medical attention.

Check with your doctor or nurse right away if any of the following side effects occur:

More common

• Absent, missed, or irregular menstrual periods
• bloating
• breast pain
• clear or bloody discharge from the nipple
• dimpling of the breast skin
• increased clear or white vaginal discharge
• inverted nipple
• longer or heavier menstrual periods
• lump in the breast or under the arm
• pain in the pelvis
• persistent crusting or scaling of the nipple
• redness or swelling of the breast
• sore on the skin of the breast that does not heal
• stomach or pelvic discomfort, aching, or heaviness
• stopping of menstrual bleeding

Incidence not known

• Abdominal or stomach pain
• anxiety
• blurred vision
• change in vaginal discharge
• chest pain
• chills
• clay-colored stools
• confusion
• cough
• dark urine
• diarrhea
• difficulty with swallowing
• dizziness or lightheadedness
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• fainting
• fast heartbeat
• fever
• headache
• hives, itching, or rash
• loss of appetite
• nausea
• pain or feeling of pressure in the pelvis
• pain, redness, or swelling in the arm or leg
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• sudden shortness of breath or troubled breathing
• sweating
• tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over affected area
• tightness in the chest
• trouble breathing
• unpleasant breath odor
• unusual tiredness or weakness
• vaginal bleeding
• vomiting of blood
• yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Your health care professional may also be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue, are bothersome, or if you have any questions about them:

More common

• Blemishes on the skin
• blistering, crusting, irritation, itching, or reddening of the skin
• cracked, dry, or scaly skin
• hair loss or thinning of the hair
• itching of the vagina or genital area
• pain at the insertion site
• pain during sexual intercourse
• pimples
• thick, white vaginal discharge with no odor or with a mild odor
• weight gain

Less common

• Discouragement
• feeling sad or empty
• irritability
• lack of appetite
• loss of interest or pleasure
• trouble concentrating
• trouble sleeping
• weight loss

Incidence not known

• Changes in menstrual or bleeding patterns
• white or brownish vaginal discharge

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Jadelle

Pharmacologic Class: Progestin

Jadelle® is a set of 2 hormone-releasing birth control implants that are surgically placed and removed under the skin of the upper arm by a trained healthcare provider. The implants are placed in the upper arm for up to 5 years.

The implants are usually inserted by your doctor within the first 7 days of your regular menstrual period. Your doctor also needs to do a pregnancy test before inserting the implants.

After the implants are inserted, your doctor should feel your arm to check that the implants are in the right place. If you cannot feel the implants in your arm, you will need to use a non-hormonal birth control (such as condoms, spermicide) until your doctor confirms that the implants are in place.

Your doctor will cover the insertion site with a gauze bandage. Keep it dry and avoid heavy lifting for 2 to 3 days. The gauze may be removed after 1 to 3 days.

Do not try to remove the implants by yourself. Call your doctor if you wish to remove your implants.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

This medicine comes with a patient information insert. Read and follow the instructions carefully. Ask your doctor if you have any questions.

• Can Plan B make your period late or cause bleeding?
• Can you drink alcohol after taking Plan B?
• How many times can you take Plan B?
• What's the weight limit for Plan B?
• What are my birth control options and how effective are they?
• Mirena, Kyleena, Skyla & Liletta - What's the difference?

View more FAQ