Kengreal (Intravenous)

Cangrelor injection is used in patients having percutaneous coronary intervention (PCI) to reduce the risk of blood clots and heart attacks.

A heart attack or stroke can happen if a blood vessel in the heart or brain is blocked by a blood clot. Cangrelor lowers the chance of a harmful blood clot forming by stopping certain cells in the blood from sticking together. This effect of cangrelor may also raise the risk of serious bleeding in some individuals.

This medicine is to be given only by or under the supervision of your doctor.

It is very important that your doctor monitors you closely while you are receiving this medicine. This will help your doctor see if the medicine is working correctly and check for any unwanted effects. Blood tests may be needed to look for unwanted effects.

This medicine may increase your risk of bleeding and bruising. Contact your doctor immediately if you notice any unusual bleeding or bruising, black or tarry stools, blood in your urine or stools, or pinpoint red spots on your skin.

Do not take other medicines unless your doctor has discussed them with you. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

In deciding to use a medicine, you and your doctor will weigh the risks against the benefits. Here are important points to consider for this medicine:

Allergies

Inform your doctor if you have ever had an unusual or allergic reaction to this medicine or any other medicines. Also, let your healthcare professional know if you have any other allergies, like to foods, dyes, preservatives, or animals. For over-the-counter products, read the label or package ingredients carefully.

Pediatric

There have not been enough studies to determine how cangrelor injection affects children. Its safety and effectiveness in this group have not been established.

Geriatric

Studies so far have not shown any specific problems in older adults that would limit the use of cangrelor injection.

Breast Feeding

There are no adequate studies in women to assess the risk to infants when using this medication while breastfeeding. Consider the potential benefits and risks before using this medication during breastfeeding.

Interactions with Medicines

Some medicines should not be used together at all, while others may be used together even if there is a chance of an interaction. In such cases, your doctor may need to adjust the dose or take other precautions. It is crucial that your healthcare professional knows if you are taking any of the medicines listed below. The following interactions are significant, but not all possible interactions are included.

Using this medicine with any of the following medicines is not recommended. Your doctor may choose not to treat you with this medication or adjust other medicines you take.

• Abrocitinib

Using this medicine with any of the following medicines is usually not recommended, but may be necessary in some cases. If both medicines are prescribed, your doctor may change the dose or how often you take one or both medicines.

• Aceclofenac
• Acemetacin
• Amtolmetin Guacil
• Apixaban
• Argatroban
• Betrixaban
• Bivalirudin
• Bromfenac
• Bufexamac
• Caplacizumab-yhdp
• Celecoxib
• Choline Salicylate
• Citalopram
• Clonixin
• Clopidogrel
• Dabigatran Etexilate
• Danaparoid
• Desirudin
• Desvenlafaxine
• Dexibuprofen
• Dexketoprofen
• Diclofenac
• Diflunisal
• Dipyrone
• Droxicam
• Duloxetine
• Edoxaban
• Escitalopram
• Etodolac
• Etofenamate
• Etoricoxib
• Felbinac
• Fenoprofen
• Fepradinol
• Feprazone
• Floctafenine
• Flufenamic Acid
• Fluoxetine
• Flurbiprofen
• Fluvoxamine
• Fondaparinux
• Heparin
• Ibuprofen
• Indomethacin
• Ketoprofen
• Ketorolac
• Lepirudin
• Levomilnacipran
• Lornoxicam
• Loxoprofen
• Lumiracoxib
• Meclofenamate
• Mefenamic Acid
• Meloxicam
• Milnacipran
• Morniflumate
• Nabumetone
• Naproxen
• Nepafenac
• Niflumic Acid
• Nimesulide
• Nimesulide Beta Cyclodextrin
• Oxaprozin
• Oxyphenbutazone
• Parecoxib
• Paroxetine
• Phenindione
• Phenprocoumon
• Phenylbutazone
• Piketoprofen
• Piroxicam
• Prasugrel
• Proglumetacin
• Propyphenazone
• Proquazone
• Protein C
• Rivaroxaban
• Rofecoxib
• Salicylic Acid
• Salsalate
• Sertraline
• Sodium Salicylate
• Sulindac
• Tenoxicam
• Tiaprofenic Acid
• Tolfenamic Acid
• Tolmetin
• Valdecoxib
• Vilazodone
• Vortioxetine
• Warfarin

Interactions with Food/Tobacco/Alcohol

Some medicines should not be taken around the time of eating certain foods, as interactions may happen. Drinking alcohol or using tobacco with certain medicines can also cause interactions. Talk with your healthcare professional about using your medicine with food, alcohol, or tobacco.

Other Medical Problems

Other medical issues may affect the use of this medicine. Be sure to inform your doctor about any other medical conditions you have, especially:

• Bleeding, active—This medicine should not be used in patients with these conditions.

Along with its necessary effects, a medicine can cause some unwanted effects. Not all of these side effects may happen, but if they do, they might need medical attention.

Check with your doctor or nurse right away if any of the following side effects happen:

More common

• Abdominal or stomach pain or swelling
• back pain
• black, tarry stools
• blood in the eyes
• blood in the urine
• bruising or purple areas on the skin
• coughing up blood
• decreased alertness
• dizziness
• headache
• joint pain or swelling
• nosebleeds

Less common

• Difficult or labored breathing
• tightness in the chest

Rare

• Cough
• difficulty with swallowing
• fast heartbeat
• hives, itching, or rash
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• noisy breathing
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• unusual tiredness or weakness

Other side effects not listed may also happen in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You can report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Kengreal

Available Dosage Forms:

• Powder for Solution

Therapeutic Class: Platelet Aggregation Inhibitor

Pharmacologic Class: ADP-Induced Aggregation Inhibitor

A nurse or other trained health professional will give you this medicine in a hospital. This medicine is given through a needle placed in one of your veins. It is given before the start of PCI.