Khapzory

Khapzory is used to treat or prevent harmful effects of methotrexate in people who have received methotrexate for bone cancer.

Khapzory is also used to treat or prevent harmful effects of methotrexate in people whose bodies do not get rid of methotrexate properly after the drug is broken down. This medicine may also be used to treat harmful effects from an overdose of methotrexate or certain other medications.

Khapzory is also used with fluorouracil in combination chemotherapy to treat colorectal cancer that has spread to other areas of the body.

Khapzory should not be used to treat anemia caused by a lack of vitamin B12.

Khapzory may also be used for other reasons not listed in this medication guide.

Follow all instructions on your medicine label and package. Inform each of your healthcare providers about all your medical conditions, allergies, and all medications you are taking.

You should not be treated with Khapzory if you are allergic to Khapzory, folic acid, or folinic acid.

If possible, before you receive Khapzory, tell your doctor or caregivers if you have:

• kidney disease; or
• if you are dehydrated.

Tell your doctor if you are pregnant or breastfeeding.

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your doctor or caregivers right away if you have:

• blisters or sores in your mouth, red or swollen gums, trouble swallowing;
• severe or ongoing diarrhea;
• a feeling of light-headedness, like you might faint;
• seizures (convulsions);
• symptoms of dehydration—feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin; or
• kidney problems—little or no urination; painful or difficult urination; swelling in your feet or ankles.

Common side effects of Khapzory may include:

• diarrhea, nausea, vomiting; or
• pain or sores in your mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Khapzory is given as an infusion into a vein. A healthcare provider will give you this injection.

For use with methotrexate, Khapzory is usually given every 3 to 6 hours.

For colorectal cancer, Khapzory is usually given daily as a 5-day treatment, repeated every 4 to 5 weeks.

After treatment with Khapzory, you will be watched to make sure this medicine has been effective.

You will need frequent medical tests to help your doctor determine how long to treat you with Khapzory.

If a healthcare professional gives you Khapzory in a clinical setting, you are unlikely to miss a dose.

If you are receiving Khapzory daily in 4-week treatment cycles, contact your doctor for guidance if you miss an appointment for your scheduled injection.

Seek emergency medical help or call the Poison Help line at 1-800-222-1222.

Follow your doctor's instructions regarding any limits on food, drinks, or activities.

Tell your doctor about all your other medicines, especially:

• seizure medicine--phenobarbital, phenytoin, primidone;
• a multivitamin or mineral supplement that contains folic acid; or
• a sulfa drug (Bactrim, Septra, Sulfatrim, SMX-TMP or SMZ-TMP, and others).

This list is not complete. Other drugs may affect Khapzory, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.