Lasix (Injection)

Furosemide injection is used to help treat fluid retention (edema) and swelling caused by congestive heart failure, liver disease (cirrhosis), kidney disease, or other medical conditions.

Furosemide injection is also used to treat congestion (blockage) caused by excess fluid in patients with chronic heart failure.

Furosemide belongs to a group of medicines called loop diuretics or "water pills." It works by acting on the kidneys to increase urine flow.

This medicine is available only with your doctor's prescription.

It is very important for your doctor to monitor you or your child closely while using this medicine. This ensures the medicine is working properly. Blood or urine tests may be required to check for unwanted effects.

This medicine may cause you or your child to lose more potassium from your body than usual (hypokalemia). This is more likely to happen if you have liver disease (for example, cirrhosis) or if you are using this medicine along with steroids (cortisone-like medicines), adrenocorticotropic hormone (ACTH), large amounts of licorice, or laxatives for a long time. Inform your doctor if you become ill with severe or ongoing nausea, vomiting, or diarrhea, and drink fluids to avoid dehydration. Contact your doctor immediately if you experience a dry mouth, increased thirst, muscle cramps, or nausea or vomiting.

This medicine may lead to hearing problems. Contact your doctor immediately if you hear ongoing ringing or buzzing or other unexplained noises in your ears, experience dizziness, a feeling of fullness in your ears, hearing loss, loss of balance, or trouble hearing.

Dizziness, lightheadedness, or fainting may occur, especially when you stand up suddenly from lying down or sitting. Getting up slowly may help. If the problem persists or worsens, consult your doctor.

This medicine may cause blood sugar levels to rise. If you or your child are diabetic and notice a change in your blood or urine sugar test results, consult your doctor.

This medicine may increase your skin's sensitivity to sunlight. Use sunscreen, wear a hat, and protective clothing when outdoors. Avoid sunlamps and tanning beds.

Ensure that any doctor or dentist who treats you is aware that you are using this medicine. This medicine may influence the results of certain medical tests.

Do not take other medicines unless your doctor has discussed them with you. This includes both prescription and nonprescription (over-the-counter) medicines for appetite control, asthma, colds, coughs, hay fever, or sinus issues.

In deciding to use a medicine, you and your doctor need to think about the risks and benefits. Here are some important points to consider for this medicine:

Allergies

Tell your doctor if you have ever had an unusual or allergic reaction to this medicine or any other medicines. Also, let your healthcare provider know about any other allergies you might have, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies have not shown any specific problems that would limit the use of furosemide injection for treating fluid retention and swelling in children. However, premature babies may be more likely to experience unwanted effects (such as kidney stones or hearing problems), so caution is needed when using furosemide injection in these patients.

There have been no studies on how age affects the use of furosemide injection for treating fluid congestion in children. Its safety and effectiveness in this age group have not been established.

Geriatric

Studies have not found any specific problems that would limit the use of furosemide injection in the elderly. However, older patients may have age-related liver, kidney, or heart issues, which may require caution and possible adjustments in the dosage when using furosemide injection.

Breast Feeding

There are no adequate studies in women to determine the risk to infants when using this medicine during breastfeeding. Consider the potential benefits and risks before taking this medicine while breastfeeding.

Interactions with Medicines

Some medicines should not be used together at all, while others may be used together with caution. If you are taking this medicine, it's very important for your healthcare provider to know if you are also taking any of the medicines listed below. The interactions listed are significant but not all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medicine or change some of the other medicines you take.

• Desmopressin

Using this medicine with any of the following medicines is usually not recommended, but may be necessary in some cases. If both medicines are prescribed together, your doctor may adjust the dose or frequency of one or both medicines.

• Acarbose
• Aceclofenac
• Acemetacin
• Albiglutide
• Albuterol
• Alogliptin
• Amikacin
• Amikacin Liposome
• Amtolmetin Guacil
• Arsenic Trioxide
• Aspirin
• Azilsartan
• Azilsartan Medoxomil
• Balsalazide
• Benazepril
• Bepridil
• Bismuth Subsalicylate
• Bromfenac
• Bromocriptine
• Bufexamac
• Buprenorphine
• Canagliflozin
• Candesartan
• Capreomycin
• Captopril
• Cefepime
• Ceftazidime
• Celecoxib
• Chloral Hydrate
• Chlorpropamide
• Choline Salicylate
• Cisplatin
• Clonixin
• Codeine
• Dapagliflozin
• Dasabuvir
• Dexibuprofen
• Dexketoprofen
• Dichlorphenamide
• Diclofenac
• Diflunisal
• Digitoxin
• Dipyrone
• Dofetilide
• Droperidol
• Droxicam
• Dulaglutide
• Empagliflozin
• Enalapril
• Enalaprilat
• Eprosartan
• Ethacrynic Acid
• Etodolac
• Etofenamate
• Etoricoxib
• Exenatide
• Felbinac
• Fenoprofen
• Fepradinol
• Feprazone
• Fexinidazole
• Floctafenine
• Flufenamic Acid
• Flurbiprofen
• Formoterol
• Foscarnet
• Fosinopril
• Gentamicin
• Glimepiride
• Glipizide
• Glyburide
• Ibuprofen
• Indomethacin
• Insulin
• Insulin Aspart, Recombinant
• Insulin Bovine
• Insulin Degludec
• Insulin Detemir
• Insulin Glulisine
• Irbesartan
• Kanamycin
• Ketanserin
• Ketoprofen
• Ketorolac
• Leflunomide
• Levomethadyl
• Levothyroxine
• Linagliptin
• Liothyronine
• Liraglutide
• Lisinopril
• Lithium
• Lixisenatide
• Lornoxicam
• Losartan
• Loxoprofen
• Lumiracoxib
• Meclofenamate
• Mefenamic Acid
• Meloxicam
• Mesalamine
• Methotrexate
• Metolazone
• Miglitol
• Moexipril
• Morniflumate
• Nabumetone
• Naproxen
• Nateglinide
• Neomycin
• Nepafenac
• Netilmicin
• Niflumic Acid
• Nimesulide
• Nimesulide Beta Cyclodextrin
• Nitisinone
• Norepinephrine
• Olmesartan
• Olsalazine
• Oxaprozin
• Oxyphenbutazone
• Parecoxib
• Paromomycin
• Perindopril
• Phenylbutazone
• Piketoprofen
• Pioglitazone
• Piroxicam
• Plazomicin
• Pramlintide
• Proglumetacin
• Propyphenazone
• Proquazone
• Quinapril
• Ramipril
• Repaglinide
• Rofecoxib
• Rosiglitazone
• Salicylic Acid
• Salsalate
• Saxagliptin
• Sitagliptin
• Sodium Salicylate
• Sotalol
• Spectinomycin
• Streptomycin
• Sulfasalazine
• Sulindac
• Tapentadol
• Telmisartan
• Tenoxicam
• Teriflunomide
• Tiaprofenic Acid
• Tobramycin
• Tolazamide
• Tolbutamide
• Tolfenamic Acid
• Tolmetin
• Trandolapril
• Trolamine Salicylate
• Valdecoxib
• Valsartan
• Vildagliptin

Using this medicine with any of the following medicines may increase the risk of certain side effects, but using both may be the best treatment for you. If both medicines are prescribed together, your doctor may adjust the dose or frequency of one or both medicines.

• Aliskiren
• Carbamazepine
• Cephaloridine
• Clofibrate
• Cyclosporine
• Dibekacin
• Fludrocortisone
• Germanium
• Ginseng
• Gossypol
• Licorice
• Pancuronium
• Tubocurarine
• Vecuronium

Interactions with Food/Tobacco/Alcohol

Some medicines should not be taken while eating or around mealtime due to possible interactions. Using alcohol or tobacco with certain medicines can also cause interactions. Talk to your healthcare provider about how to take your medicine with food, alcohol, or tobacco.

Other Medical Problems

Having other medical problems may affect how this medicine is used. Make sure to tell your doctor about any other medical conditions you have, especially:

• Allergy to medical adhesives or
• Anuria (not being able to pass urine) or
• Liver disease (such as cirrhosis or ascites)—Should not be used in patients with this condition.

• Allergy to sulfa drugs (such as sulfamethoxazole, sulfasalazine, sulfisoxazole, Azulfidine®, Bactrim®, Gantrisin®, or Septra®) or
• Blood or bone marrow problems or
• Dehydration or
• Electrolyte imbalance (such as low potassium, low sodium, low magnesium, low calcium) or
• Enlarged prostate or
• Gout or
• Hearing problems (like tinnitus) or
• High uric acid levels in the blood or
• Low blood volume or
• Severe liver disease (like hepatic coma) or
• Systemic lupus erythematosus (SLE) or
• Trouble urinating—Use with caution. This may worsen these conditions.

• Diabetes—This medicine may raise blood sugar levels.

• Hypertension (high blood pressure)—Your dose of blood pressure medications may need adjustment to prevent your blood pressure from dropping too low.

• Low protein levels in the blood due to kidney problems or
• History of radiocontrast nephropathy (kidney problems)—May worsen side effects.

• Severe kidney disease—Use with caution. The effects may be stronger due to slower removal of the medicine from the body.

Along with its necessary effects, a medicine may cause some unwanted effects. Not all of these side effects may happen, but if they do, they might require medical attention.

Check with your doctor or nurse right away if any of the following side effects occur:

Rare

• Chest pain or tightness
• Chills
• Cough or hoarseness
• Fever
• General feeling of tiredness or weakness
• Headache
• Lower back or side pain
• Painful or difficult urination
• Sore throat
• Sores, ulcers, or white spots on the lips or in the mouth
• Swollen or painful glands
• Trouble breathing
• Unusual bleeding or bruising
• Unusual tiredness or weakness

Incidence not known

• Back or leg pains
• Black, tarry stools
• Bladder spasm
• Bleeding gums
• Blistering, peeling, or loosening of the skin
• Bloody or cloudy urine
• Blurred vision
• Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• Clay-colored stools
• Cold sweats
• Confusion
• Constipation
• Continuing ringing or buzzing or other unexplained noise in the ears
• Coughing up blood
• Diarrhea
• Dizziness, faintness, or lightheadedness when getting up from a lying or sitting position
• Dry mouth
• Fast heartbeat
• Fever with or without chills
• Flushed, dry skin
• Fruit-like breath odor
• Hearing loss
• Increased hunger or thirst
• Increased or decreased urination
• Indigestion
• Itching
• Joint stiffness or swelling
• Loss of appetite
• Nausea or vomiting
• Nosebleeds
• Pain where a shot was given
• Pains in the stomach, side, or abdomen, possibly radiating to the back
• Pale skin
• Pinpoint red spots on the skin
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Red, irritated eyes
• Red skin lesions, often with a purple center
• Scaly skin
• Skin rash
• Sweating
• Swelling of the feet or lower legs
• Swollen glands
• Unpleasant breath odor
• Unusual weight loss
• Yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Your health care professional may also be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

• Feeling of constant movement of self or surroundings
• Hives or welts
• Increased sensitivity of the skin to sunlight
• Muscle spasm
• Redness or other discoloration of the skin
• Restlessness
• Sensation of spinning
• Severe sunburn

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Furomide M.D.
• Lasix

Available Dosage Forms:

• Solution

Therapeutic Class: Cardiovascular Agent

Pharmacologic Class: Diuretic, Loop

A nurse or other trained health professional will give you or your child this medicine in a hospital. It is given through a needle placed into one of your veins, or as a shot into a muscle or under your skin, usually in the stomach area.

Your doctor will give you a few doses of this medicine until your condition improves, and then switch you or your child to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

You or your caregiver may be trained to prepare and apply the medicine at home. Be sure that you understand how to use the medicine. Do not use more medicine or use it more often than your doctor tells you to.

To use the prefilled cartridge with the single-use on-body infusor:

• Wash your hands with soap and water before and after using this medicine.
• You will be shown the body areas where the on-body infusor can be worn. Use a different body area each time you wear the infusor. Keep track of the application site to make sure you rotate body areas. This will help prevent skin problems from the injections. Do not apply into areas where the skin is bruised, hardened, irritated, red, tender, or broken.
• Do not apply lotions oils, or ointments to the stomach area. Avoid putting the on-body infusor where belts, waistbands, or other types of clothing that may rub against, disturb, or dislodge. Application site should be hairless or nearly hairless. You may shave the skin or cut the hair.
• Check the liquid in the prefilled cartridge. It should be clear to slightly yellow. Do not use the cartridge if the liquid is cloudy or discolored.
• Do not use if the packaging is opened, dropped, broken, or damaged. Do not use the medicine within 12 inches of mobile phones, tablets, computers, or wireless devices (eg, TV remote control, bluetooth keyboard or mouse).
• Do not touch the blue start button until the on-body infusor is on the skin. Do not touch or fully open the cartridge holder until you are ready. Do not remove until the injection is complete (indicator turns solid green light, beeping sound, and white plunger rod filling the window).
• Do not shower, bathe, swim, or exercise that will make you sweat while wearing the on-body infusor. Allow the medicine to deliver for at least 5 hours.
• If the on-body infusor falls off, call your doctor right away. Do not reapply or reuse it. Do not apply new on-body infusor unless your doctor tells you to.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For injectable dosage form (prefilled cartridge):For congestion caused by excess amount of fluid: Adults—30 milligrams (mg) injected under your skin for the first hour, followed by 12.5 mg per hour for 4 hours. Each cartridge contains 80 mg furosemide. The amount of medicine delivered is pre-programmed with a single-use on-body infusor. Children—Use and dose must be determined by your doctor.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep the medicine in its original carton until you are ready to use it. Protect it from light.

• Should you drink a lot of water when taking Lasix?
• Are losartan and losartan potassium the same or different drugs?
• How long after taking Lasix would you expect to urinate?
• Can you take Lasix for weight loss?
• What are the equivalent dosages of bumetanide, furosemide & torsemide?