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Lokelma

Generic name: sodium zirconium cyclosilicate

Used for hyperkalemia
Last updated November 2, 2026 0 views
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What is Lokelma?

Lokelma is used to treat hyperkalemia (high levels of potassium in the blood) in adults.

Lokelma works directly in the intestines and is not absorbed into your bloodstream.

Lokelma may also be used for purposes not listed in this medication guide.

This section was rewritten for readability and reviewed for meaning.

How should I take Lokelma?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may sometimes change your dose. Use the medicine exactly as directed.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

You will need medical tests to help your doctor decide how long to treat you with Lokelma.

Store at room temperature away from moisture and heat.

Lokelma can make it harder for your body to absorb other medicines you take by mouth. If you take any other medicines, take them 2 hours before or 2 hours after you take this medicine.

This section was rewritten for readability and reviewed for meaning.

Warnings

Follow all directions on your medicine label and package.

Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

This section was rewritten for readability and reviewed for meaning.

Before taking this medicine

Tell your doctor if you have ever had:

  • slow digestion;
  • a bowel obstruction or severe constipation;
  • heart problems; or
  • if you are on a low-salt diet.

Since Lokelma is not absorbed into the bloodstream, it is not expected to be harmful during pregnancy or while nursing. Tell your doctor if you are pregnant or breast-feeding.

This section was rewritten for readability and reviewed for meaning.

Lokelma side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Lokelma contains sodium and may cause swelling or rapid weight gain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

This section was rewritten for readability and reviewed for meaning.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if it's nearly time for your next dose. Do not use two doses at the same time.

This section was rewritten for readability and reviewed for meaning.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Follow your doctor's instructions regarding any restrictions on food, drinks, or activities.

This section was rewritten for readability and reviewed for meaning.

What other drugs will affect Lokelma?

Other drugs may affect Lokelma, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

This section was rewritten for readability and reviewed for meaning.

Common questions about Lokelma

How does the drug Lokelma work?
Lokelma (sodium zirconium cyclosilicate) is an oral medicine that treats high potassium levels (hyperkalemia) in adults. It binds to potassium in the small and large intestines, exchanges it for hydrogen and sodium, and increases potassium excretion in the feces. Lokelma should not be used as an emergency treatment for life-threatening hyperkalemia due to its delayed onset. Continue reading

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Before you take this medicine: the information on this page is general and may not cover your personal circumstances. Read the label supplied with your medicine and ask a pharmacist or doctor if you are unsure, especially if you are pregnant, breastfeeding, taking other medicines or managing a long-term condition.
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Content is provided for education and is not medical advice. See our medical disclaimer.