Lozol (Oral)

Indapamide is used alone or with other medicines to treat high blood pressure (hypertension). High blood pressure makes the heart and arteries work harder. If it lasts for a long time, the heart and arteries may not work properly. This can harm the blood vessels in the brain, heart, and kidneys, leading to a stroke, heart failure, or kidney failure. High blood pressure may also raise the risk of heart attacks. Controlling blood pressure can help reduce the chances of these issues.

Indapamide is also used to treat salt and fluid retention (edema) caused by congestive heart failure.

Indapamide is a thiazide-like diuretic (water pill). It helps lower blood pressure by reducing the amount of water in the body and increasing urine flow.

This medicine is available only with your doctor's prescription.

It is very important for your doctor to check your progress at regular visits to ensure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Contact your doctor right away if you experience confusion, decreased urine, dizziness, drowsiness, dry mouth, increased thirst, fast or irregular heartbeat or pulse, headache, muscle pains or cramps, nausea or vomiting, seizures, swelling of the face, ankles, or hands, trouble breathing, or unusual tiredness or weakness. These may be signs of an electrolyte imbalance (e.g., low sodium or potassium in the blood).

This medicine may cause changes in your blood sugar levels. Talk to your doctor if you have these problems or if you notice a change in your blood or urine sugar test results.

Get in touch with your doctor immediately if you have blurred vision, difficulty reading, eye pain, or any other change in vision during or after treatment. This could indicate a serious eye problem. Your doctor will want you to see an ophthalmologist (eye doctor) for an eye exam.

Make sure any doctor or dentist treating you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests.

Do not take other medicines unless you have discussed them with your doctor. This includes prescription or nonprescription (over-the-counter) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, as they may raise your blood pressure.

In deciding to use a medicine, you and your doctor must consider the risks of taking the medicine against the benefits it may provide. For this medicine, you should think about the following:

Allergies

Inform your doctor if you have ever had any unusual or allergic reactions to this medicine or any other medicines. Also, let your healthcare professional know if you have other allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

There have not been enough studies to determine how age affects the use of indapamide in children. Its safety and effectiveness have not been established for this age group.

Geriatric

Studies so far have not shown any specific problems in older adults that would limit the use of indapamide. However, older patients are more likely to have liver, kidney, or heart issues related to aging, which may require a dosage adjustment for those taking indapamide.

Breast Feeding

There are no adequate studies in women to determine the risk to infants when using this medication while breastfeeding. Carefully weigh the potential benefits against the risks before taking this medication during breastfeeding.

Interactions with Medicines

Some medicines should not be used together at all, while in other cases, two different medicines may be used together even if there is a chance of interaction. In these situations, your doctor may want to adjust the dose or take other precautions. It is very important for your healthcare professional to know if you are taking any of the medicines listed below while using this medicine. The following interactions are highlighted based on their potential significance and may not include all possible interactions.

Using this medicine with any of the following medicines is usually not recommended, but may be necessary in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you take one or both.

• Acarbose
• Aceclofenac
• Acemetacin
• Acetyldigoxin
• Albiglutide
• Albuterol
• Alogliptin
• Amtolmetin Guacil
• Arsenic Trioxide
• Aspirin
• Bromfenac
• Bromocriptine
• Bufexamac
• Buprenorphine
• Canagliflozin
• Celecoxib
• Chlorpropamide
• Choline Salicylate
• Clonixin
• Codeine
• Dapagliflozin
• Deslanoside
• Desmopressin
• Dexibuprofen
• Dexketoprofen
• Diclofenac
• Diflunisal
• Digitalis
• Digitoxin
• Digoxin
• Dipyrone
• Dofetilide
• Droperidol
• Droxicam
• Dulaglutide
• Empagliflozin
• Etodolac
• Etofenamate
• Etoricoxib
• Exenatide
• Felbinac
• Fenoprofen
• Fepradinol
• Feprazone
• Floctafenine
• Flufenamic Acid
• Flurbiprofen
• Formoterol
• Glimepiride
• Glipizide
• Glyburide
• Ibuprofen
• Indomethacin
• Insulin
• Insulin Aspart, Recombinant
• Insulin Bovine
• Insulin Degludec
• Insulin Detemir
• Insulin Glulisine
• Ketanserin
• Ketoprofen
• Ketorolac
• Levomethadyl
• Linagliptin
• Liraglutide
• Lithium
• Lixisenatide
• Lornoxicam
• Loxoprofen
• Lumiracoxib
• Meclofenamate
• Mefenamic Acid
• Meloxicam
• Methotrexate
• Metildigoxin
• Miglitol
• Morniflumate
• Nabumetone
• Naproxen
• Nateglinide
• Nepafenac
• Niflumic Acid
• Nimesulide
• Nimesulide Beta Cyclodextrin
• Oxaprozin
• Oxyphenbutazone
• Parecoxib
• Phenylbutazone
• Piketoprofen
• Pioglitazone
• Piroxicam
• Pramlintide
• Proglumetacin
• Propyphenazone
• Proquazone
• Repaglinide
• Rofecoxib
• Rosiglitazone
• Salicylic Acid
• Salsalate
• Saxagliptin
• Sitagliptin
• Sodium Salicylate
• Sotalol
• Sulindac
• Tapentadol
• Tenoxicam
• Tiaprofenic Acid
• Tolazamide
• Tolbutamide
• Tolfenamic Acid
• Tolmetin
• Valdecoxib
• Vildagliptin

Using this medicine with any of the following medicines may increase the risk of certain side effects, but using both may be the best treatment option for you. If both medicines are prescribed together, your doctor may change the dose or how often you take one or both.

• Aminolevulinic Acid
• Gossypol
• Licorice

Interactions with Food/Tobacco/Alcohol

Some medicines should not be taken around mealtime or with certain foods due to potential interactions. Drinking alcohol or using tobacco with certain medicines may also lead to interactions. Discuss with your healthcare professional how to use your medicine with food, alcohol, or tobacco.

Other Medical Problems

Having other medical issues may affect how you use this medicine. Make sure to inform your doctor if you have any other medical conditions, especially:

• Anuria (not able to form urine) or
• Sulfa drug allergy—Should not be used in patients with these conditions.

• Diabetes or
• Electrolyte imbalance (for example, high calcium or low magnesium, potassium, sodium in the body) or
• Glaucoma, angle-closure or
• Gout or
• Heart rhythm problems or
• Hyperglycemia (high blood sugar) or
• Hyperuricemia (high uric acid in the blood) or
• Liver disease or
• Myopia (nearsightedness) or
• Systemic lupus erythematosus (SLE)—Use with caution. May worsen these conditions.

• Kidney disease—Use with caution. The effects may be stronger because the body removes the medicine more slowly.

• Sympathectomy (a surgical procedure where certain nerves are removed)—Use with caution. The effects of this medicine may be increased.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Agitation
• anxiety
• black, tarry stools
• chest pain
• cough or hoarseness
• dark urine
• dizziness
• fever or chills
• headache
• irritability
• light-colored stools
• lower back or side pain
• muscle cramps or spasms
• painful or difficult urination
• sneezing
• sore throat
• sores, ulcers, or white spots in the mouth or on the lips
• stuffy or runny nose
• swollen glands
• unusual bleeding or bruising
• unusual tiredness or weakness
• yellow eyes and skin

Less common

• Blurred vision
• body aches or pain
• burning, dry, or itching eyes
• change in consciousness
• cold sweats
• confusion
• decreased urine output
• discharge, excessive tearing
• discouragement
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• drowsiness
• dry mouth
• dryness or soreness of the throat
• excessive muscle tone
• fast, irregular, pounding, or racing heartbeat or pulse
• feeling sad or empty
• flushed, dry skin
• frequent urination
• fruit-like breath odor
• increased hunger, thirst, and urination
• increased urge to urinate during the night
• increased volume of pale, dilute urine
• joint pain, stiffness, or swelling
• lack of appetite
• loss of interest or pleasure
• lower back, side, or stomach pain
• mood changes
• muscle pain, cramps, tension, stiffness, or tightness
• nervousness
• pain or tenderness around the eyes and cheekbones
• redness, pain, swelling of the eye, eyelid, or inner lining of eyelid
• sugar in the urine
• sweating
• swelling of the face, feet, lower legs, ankles, or hands
• tender, swollen glands in the neck
• tightness in the chest
• trouble breathing
• trouble concentrating
• trouble in swallowing
• trouble sleeping
• voice changes
• waking to urinate at night

Incidence not known

• Change in near or distance vision
• difficulty in focusing the eyes
• eye pain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Back pain
• blistering, peeling, loosening of the skin
• diarrhea
• increased sensitivity of skin to sunlight
• red irritated eyes
• red skin lesions, often with a purple center
• redness or other discoloration of the skin
• severe sunburn

Less common

• Acid or sour stomach
• belching
• bloating or swelling of the face, arms, hands, lower legs, or feet
• constipation
• decreased interest in sexual intercourse
• heartburn
• hives or rash
• inability to have or keep an erection
• indigestion
• lack or loss of strength
• loss in sexual ability, desire, drive, or performance
• nausea
• rapid weight gain
• stomach discomfort or upset
• tingling of the hands or feet
• unusual weight gain or loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Lozol

Available Dosage Forms:

• Tablet

Therapeutic Class: Cardiovascular Agent

Pharmacologic Class: Diuretic

Chemical Class: Thiazide Related

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt) or potassium. Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to receive it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets): For fluid retention (edema): Adults—At first, 2.5 milligrams (mg) once a day, taken in the morning. Your doctor may adjust your dose as needed. However, the dose is usually not more than 5 mg. Children—Use and dose must be determined by your doctor. For high blood pressure: Adults—At first, 1.25 milligrams (mg) once a day, taken in the morning. Your doctor may adjust your dose as needed. However, the dose is usually not more than 5 mg. Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.