Lufyllin-400 (Oral)

Dyphylline is used to treat and/or prevent symptoms of bronchial asthma, chronic bronchitis, and emphysema. It helps by opening up the bronchial tubes (the air passages in the lungs) and increasing the flow of air through them.

You can get this medicine only with your doctor's prescription.

Your doctor will monitor your progress during regular visits, particularly in the first few weeks of your treatment with this medicine.

Before any surgery that needs general anesthesia, inform the medical doctor in charge that you are taking this medicine.

In deciding to use a medicine, the risks of taking the medicine must be weighed against the benefits it will provide. This is a decision you and your doctor will make. For this medicine, consider the following:

Allergies

Inform your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also, let your healthcare professional know if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Using other bronchodilator medicines is preferred.

Geriatric

As with younger patients, using other bronchodilator medicines is preferred. Additionally, older patients with kidney disease may need a lower dose of dyphylline compared to older adults without kidney disease.

Breast Feeding

There are no adequate studies in women to determine the risk to infants when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

While some medicines should not be used together at all, in other cases, two different medicines may be used together even if an interaction might occur. In these situations, your doctor may want to adjust the dose, or take other precautions. When you are taking this medicine, it is especially important for your healthcare professional to know if you are taking any of the medicines listed below. The following interactions have been selected based on their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Riociguat

Using this medicine with any of the following medicines is usually not recommended, but may be necessary in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Adenosine
• Regadenoson

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

Having other medical problems may affect the use of this medicine. Make sure to inform your doctor if you have any other medical issues, especially:

• Heart or blood vessel disease or
• Stomach ulcer (or a history of) or other stomach problems—May worsen these conditions.

• Heart failure or
• Kidney disease—The effects of the medicine may be increased.

Along with its necessary effects, a medicine may cause some unwanted effects. Not all of these side effects may occur, but if they do, they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Less common

• Heartburn
• vomiting

Symptoms of overdose

• Abdominal pain (continuing or severe)
• confusion or change in behavior
• convulsions (seizures)
• dark or bloody vomit
• diarrhea
• fast or irregular heartbeat
• nervousness or restlessness (continuing)
• trembling (continuing)

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Your health care professional may also be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• Fast heartbeat
• headache
• increased urination
• nausea
• nervousness
• trembling
• trouble with sleeping

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Dilor-200
• Dilor-400
• Dylix
• Lufyllin
• Lufyllin-400

In Canada

• Protophylline Alcohol And Sugar Free

Chemical Class: Methylxanthine

This medicine works best when there is a constant amount in the blood. To help keep the amount constant, dyphylline must be taken at regularly spaced times, as ordered by your doctor. Do not miss any doses.

This medicine also works best when taken with a glass of water on an empty stomach (either 30 minutes to 1 hour before meals or 2 hours after meals). However, in some cases your doctor may want you to take this medicine with meals or right after meals to lessen stomach upset.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage forms (elixir or tablets): For asthma, bronchitis, or emphysema: Adults—Dose is based on body weight. The usual dose is 15 milligrams (mg) per kilogram (kg) of body weight up to four times per day. Children—Dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Do not refrigerate. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.