Lumasiran

Lumasiran is used to treat a type of hyperoxaluria (high levels of oxalate in your urine). Oxalate is a natural chemical found in the body and in some foods. Having too much oxalate in the urine can lead to kidney stones or kidney failure.

Lumasiran can be used by adults and children of all ages.

Lumasiran may also be used for other reasons not mentioned in this medication guide.

Lumasiran is injected under the skin.

A healthcare provider will give you this injection.

Lumasiran is usually given once every 1 to 3 months.

Lumasiran doses are based on weight in children. Your child's dose may change if the child gains or loses weight.

You may need to follow a special diet. Follow all instructions from your doctor or dietitian. Learn about the foods to eat or avoid to help control your condition.

You may need to follow a special diet to help manage your condition.

Tell your doctor if you are pregnant or breastfeeding.

Get emergency medical help if you notice any signs of an allergic reaction: hives; trouble breathing; swelling of your face, lips, tongue, or throat.

Common side effects may include pain, redness, itching, or swelling at the injection site.

This is not a complete list of side effects, and others may happen. Contact your doctor for medical advice about side effects. You can report side effects to the FDA at 1-800-FDA-1088.

Usual Adult Dose for Primary Hyperoxaluria:

Weight at least 20 kg:-Loading dose: 3 mg/kg subcutaneously once a month for 3 doses-Maintenance dose: 3 mg/kg subcutaneously every 3 months (quarterly)Comments:-Dosing is based on actual body weight.-The maintenance dose should begin 1 month after the last loading dose.Use: For the treatment of primary hyperoxaluria type 1 (PH1) to lower urinary and plasma oxalate levels

Usual Pediatric Dose for Primary Hyperoxaluria:

Weight less than 10 kg:-Loading dose: 6 mg/kg subcutaneously once a month for 3 doses-Maintenance dose: 3 mg/kg subcutaneously once a monthWeight 10 to less than 20 kg:-Loading dose: 6 mg/kg subcutaneously once a month for 3 doses-Maintenance dose: 6 mg/kg subcutaneously every 3 months (quarterly)Weight at least 20 kg:-Loading dose: 3 mg/kg subcutaneously once a month for 3 doses-Maintenance dose: 3 mg/kg subcutaneously every 3 months (quarterly)Comments:-Dosing is based on actual body weight.-The maintenance dose should begin 1 month after the last loading dose.Use: For the treatment of PH1 to lower urinary and plasma oxalate levels

Call your doctor for guidance if you miss your appointment for the lumasiran injection.

Since lumasiran is administered by a healthcare professional in a medical setting, an overdose is unlikely to happen.

Follow your doctor's instructions regarding any restrictions on food, drinks, or activities.

Other drugs may affect lumasiran, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you begin or stop using.