Lusutrombopag

Lusutrombopag is a man-made version of a protein that helps your body make more platelets (blood-clotting cells). Lusutrombopag can reduce the risk of bleeding by increasing the number of platelets in your blood.

Lusutrombopag is used to treat thrombocytopenia (a shortage of platelets in the blood) in adults with chronic liver disease who are about to have a medical procedure.

Lusutrombopag is not a cure for thrombocytopenia, and it will not bring your platelet counts back to normal.

Lusutrombopag may also be used for reasons not mentioned in this medication guide.

Follow all instructions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Lusutrombopag is typically taken once daily for 7 days, starting 8 to 14 days before your procedure.

You can take lusutrombopag with or without food.

Carefully follow your doctor's dosing instructions regarding when to take this medication and when your procedure is scheduled.

Store at room temperature, away from moisture and heat. Keep each tablet in the foil blister pack until you are ready to take a dose.

Follow all instructions on your medicine label and package. Inform each of your healthcare providers about all your medical conditions, allergies, and all medications you are taking.

You should not use lusutrombopag if you are allergic to it.

Tell your doctor if you have ever had:

• a blood clot; or
• a bleeding or blood clotting disorder other than thrombocytopenia.

It is not known whether lusutrombopag will harm an unborn baby. Tell your doctor if you are pregnant.

It is not safe to breast-feed a baby while you are using this medicine. Also do not breast-feed for at least 28 days after your last dose.

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

You could develop a blood clot if your platelet count gets too high while you are taking lusutrombopag. Call your doctor or get emergency medical help if you have:

• sudden numbness or weakness (especially on one side of the body);
• problems with vision or speech;
• swelling or redness in an arm or leg;
• fever, chills;
• stomach pain (upper right side), vomiting;
• jaundice (yellowing of the skin or eyes); or
• bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds.

Common side effects of lusutrombopag may include:

• headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Usual Adult Dose for Thrombocytopenia:

3 mg orally once a day starting 8 to 14 days prior to a scheduled procedureDuration of therapy: 7 daysComments: Patients should undergo their procedure 2 to 8 days after the last dose.Use: Treatment of thrombocytopenia in patients with chronic liver disease who are scheduled to undergo a procedure.

Take the missed dose on the same day you remember it. Take your next dose at the regular time and continue with your once-daily schedule. Do not use 2 doses in one day.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Other drugs may affect Lusutrombopag, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.