Mannitol inhalation

Bronchitol is used with other medicines to help adults with cystic fibrosis breathe better. You will only receive Bronchitol after passing a tolerance test to ensure you can safely use mannitol inhalation.

Aridol is part of medical testing for asthma in children who are at least 6 years old.

Mannitol inhalation may also be used for reasons not mentioned in this medication guide.

Aridol is only given in a medical setting for testing asthma or other lung disorders. If the test causes you severe breathing problems, you will be treated quickly.

You will receive your first Bronchitol dose (a tolerance test dose) in a clinic. Your doctor will check your breathing to ensure mannitol inhalation is safe for you.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Read and carefully follow any Instructions for Use that come with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

The usual schedule for Bronchitol is one dose in the morning and one dose about 2 to 3 hours before bedtime.

Your doctor will prescribe another inhaled medicine that you should use 5 to 15 minutes before each dose of Bronchitol. Do not use any other medicines not recommended by your doctor.

Do not swallow a mannitol inhalation capsule. It is for use only in the inhaler device provided with this medicine.

Each Bronchitol inhaler device should be used for no more than 7 days. Replace it with a new inhaler each week.

Do not change your dose or stop using Bronchitol without your doctor's advice.

Store at room temperature away from moisture and high heat. Do not freeze or refrigerate.

Throw away any Bronchitol capsules that have been kept at temperatures higher than 86 degrees F (30 degrees C). Throw away the Bronchitol inhaler device after 7 days of use.

You should not use mannitol inhalation if you have ever had an allergic reaction or bronchospasm (wheezing, chest tightness, trouble breathing) after using mannitol. You also should not use this medicine if you are allergic to the ingredients in the capsule.

You should not use this medicine if you've ever had an allergic reaction or bronchospasm (wheezing, chest tightness, trouble breathing) after using mannitol.

You also should not use this medicine if you are allergic to any ingredients used to make the capsules (such as gelatin, shellac, isopropyl alcohol, propylene glycol, ammonia solution, titanium dioxide, or iron oxides).

You should not be treated with Aridol if you have:

• an aneurysm;
• untreated or uncontrolled high blood pressure; or
• a recent heart attack or stroke.

Tell your doctor if you have ever had:

• a severe cough, or a cough with bloody mucus;
• a collapsed lung or punctured lung;
• angina (chest pain);
• surgery on your stomach or chest, or your eyes;
• if you have ever coughed up blood; or
• if you have active symptoms of an infection that could affect your lungs (such as stuffy nose, sore throat, fever, chills, cough, chest pain, or trouble breathing).

Tell your doctor if you are pregnant or breastfeeding.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Mannitol inhalation may cause serious side effects. Call your doctor immediately if you have:

• wheezing, choking, or other breathing problems after using this medicine; or
• if you cough up large amounts of blood.

Common side effects of Bronchitol may include:

• pain or irritation in your mouth or throat;
• trouble swallowing;
• fever; or
• vomiting.

Common side effects of Aridol may include:

• wheezing, trouble breathing, chest discomfort;
• cough, throat pain or irritation;
• runny nose;
• headache, dizziness; or
• nausea, vomiting.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Usual Adult Dose for Oliguria:

Renal function test dose prior to initiation of treatment: 0.2 g/kg IV over 3 to 5 min resulting in a urine flow of at least 30 to 50 mL/hr. A second test dose may be administered if the urine flow does not increase. If no response is seen following the second test dose, the patient should be reevaluated.Treatment: 300 to 400 mg/kg (21 to 28 g for a 70 kg patient) or up to 100 g of 15% to 20% solution IV once. Treatment should not be repeated in patients with persistent oliguria.Prevention (for use during cardiovascular and other types of surgery): 50 to 100 g IV. usually a 5, 10, or 20% solution is used depending on the fluid requirements of the patient.

Usual Adult Dose for Cerebral Edema:

0.25 to 2 g/kg as a 15 to 20% solution IV over at least 30 min administered not more frequently than every 6 to 8 hrs.To yield a satisfactory reduction in intracranial pressure, the osmotic gradient between the blood and cerebrospinal fluid should remain approximately 20 mOsmol.In small &/or debilitated patients 500 mg/kg may be sufficient.

Call your doctor for instructions if you miss a dose.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include cough, wheezing, or severe shortness of breath.

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Other drugs may affect mannitol inhalation, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.