Measles, mumps, and rubella virus vaccine live (Subcutaneous, Intramuscular)

Measles, mumps, and rubella virus vaccine (live) is a vaccine that helps protect against infections caused by measles, mumps, and rubella (German measles). It works by prompting your body to create its own defense (antibodies) against the viruses.

Measles (also called coughing measles, hard measles, morbilli, red measles, rubeola, and 10-day measles) is a highly contagious infection. Getting measles can lead to serious issues, including stomach problems, pneumonia, ear infections, sinus problems, convulsions (seizures), brain damage, and potentially death. The risk of severe complications and death is higher for adults and infants compared to children and teenagers.

Mumps is an infection that can lead to serious complications, such as encephalitis and meningitis, which affect the brain. Additionally, adolescent boys and men are at high risk for a condition called orchitis, which causes pain and swelling in the testicles and scrotum, and in rare cases, sterility. Mumps infection can also cause spontaneous abortion (miscarriage) in women during the first 3 months of pregnancy.

Rubella (also known as German measles) is a serious infection that can lead to miscarriages, stillbirths, or birth defects in unborn babies when pregnant women contract the disease.

This vaccine must only be given by or under the supervision of your doctor or another health care professional.

Be sure to tell your doctor about any side effects that happen after you get this vaccine.

Do not become pregnant for 1 month after getting this vaccine without checking with your doctor first. There is a risk that this vaccine may cause problems during pregnancy. If you think you might be pregnant, let your doctor know right away.

This vaccine can cause serious allergic reactions, including anaphylaxis, which can be life-threatening and needs immediate medical help. Tell your doctor immediately if you have a rash, itching, a fast heartbeat, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after getting the vaccine.

This vaccine will reduce the number of some types of blood cells in your body. Because of this, you might bleed or get infections more easily. To help with these issues, avoid being around sick people or those with infections. Wash your hands often. Stay away from rough sports or situations where you could get bruised, cut, or injured. Brush and floss your teeth gently. Be cautious when using sharp objects, like razors and fingernail clippers.

Fainting may happen after you receive this vaccine. You might also experience vision changes, numbness or tingling in your arms, hands, or feet, or jerky movements of the arms and legs. Your doctor may want you to be watched after you get the injection to help prevent and manage fainting.

The tip caps of the prefilled syringe contain dry natural rubber (a type of latex), which may cause allergic reactions in people who are sensitive to latex. Tell your doctor if you have a latex allergy before getting this medicine.

This vaccine may not protect everyone who gets it. This vaccine will not treat symptoms of measles, mumps, and rubella infection if you already have the disease.

Tell your doctor that you have received this vaccine:

• If you will be getting a tuberculin skin test within 4 to 6 weeks after receiving this vaccine. The results of the test may be affected by this vaccine.
• If you will be receiving any other live virus vaccines within 1 month after receiving this vaccine.
• If you will be receiving blood transfusions or other blood products within 2 weeks after receiving this vaccine.
• If you will be receiving gamma globulin or other globulins within 2 weeks after receiving this vaccine.

In deciding to use a vaccine, you and your doctor need to weigh the risks of the vaccine against the benefits it provides. Here are some important points to consider for this vaccine:

Allergies

Inform your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also, let your healthcare professional know if you have any other allergies, such as to foods, dyes, preservatives, or animals. If you are using non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies have not been done to determine how Priorix® injection affects infants younger than 12 months. Safety and effectiveness have not been established.

M-M-R® II is not recommended for children younger than 12 months. Safety and effectiveness of the measles vaccine have not been established for children younger than 6 months, and for mumps and rubella vaccines in children younger than 12 months.

Geriatric

Studies on how Priorix® and M-M-R® II injections affect older adults have not been performed, but there are no known specific problems in older adults that would limit the usefulness of Priorix® injection.

Breast Feeding

Research suggests that this medication poses minimal risk to infants when used during breastfeeding.

Interactions with Medicines

Some medicines should not be used together at all, while others may be used together even if an interaction could occur. In these cases, your doctor might adjust the dose, or other precautions may be necessary. It is very important for your healthcare professional to know if you are taking any of the medicines listed below when you receive this vaccine. The following interactions are based on their potential significance and are not a complete list.

Receiving this vaccine with any of the following medicines is not recommended. Your doctor may choose not to use this vaccine or modify some of the other medicines you take.

• Alemtuzumab
• Bendamustine
• Bortezomib
• Bosutinib
• Cabazitaxel
• Capecitabine
• Carboplatin
• Carfilzomib
• Carmustine
• Chlorambucil
• Cisplatin
• Cladribine
• Clofarabine
• Cyclophosphamide
• Cytarabine
• Cytarabine Liposome
• Dacarbazine
• Dasatinib
• Daunorubicin
• Daunorubicin Citrate Liposome
• Daunorubicin Liposome
• Deflazacort
• Docetaxel
• Doxorubicin
• Epirubicin
• Etoposide
• Fludarabine
• Fluorouracil
• Gemcitabine
• Gemtuzumab Ozogamicin
• Hydroxyurea
• Idarubicin
• Ifosfamide
• Imatinib
• Interferon Alfa
• Irinotecan
• Irinotecan Liposome
• Lomustine
• Mechlorethamine
• Melphalan
• Mercaptopurine
• Methotrexate
• Mitomycin
• Mitoxantrone
• Nelarabine
• Nilotinib
• Ofatumumab
• Oxaliplatin
• Paclitaxel
• Paclitaxel Protein-Bound
• Pemetrexed
• Pentostatin
• Ponatinib
• Procarbazine
• Rituximab
• Temozolomide
• Teniposide
• Thiotepa
• Topotecan
• Tositumomab
• Vinblastine
• Vinorelbine

Receiving this vaccine with any of the following medicines is usually not recommended, but may be necessary in some situations. If both medicines are prescribed together, your doctor may adjust the dose or how often you take one or both medicines.

• Adalimumab
• Anifrolumab-fnia
• Ansuvimab-zykl
• Antithymocyte Globulin Rabbit
• Atoltivimab
• Axicabtagene Ciloleucel
• Azathioprine
• Baricitinib
• Belatacept
• Betibeglogene Autotemcel
• Bimekizumab-bkzx
• Brexucabtagene Autoleucel
• Brodalumab
• Canakinumab
• Certolizumab Pegol
• Deucravacitinib
• Dupilumab
• Efgartigimod Alfa-fcab
• Elivaldogene Autotemcel
• Emapalumab-lzsg
• Etanercept
• Etrasimod
• Everolimus
• Fingolimod
• Golimumab
• Guselkumab
• Hyaluronidase
• Immune Globulin
• Inebilizumab-cdon
• Infliximab
• Ixekizumab
• Leflunomide
• Leniolisib
• Meningococcal Vaccine
• Mirikizumab-mrkz
• Mycophenolic Acid
• Ocrelizumab
• Ozanimod
• Ponesimod
• Rilonacept
• Risankizumab-rzaa
• Ritlecitinib
• Rozanolixizumab-noli
• Sarilumab
• Satralizumab-mwge
• Secukinumab
• Siponimod
• Sirolimus
• Spesolimab-sbzo
• Tacrolimus
• Teplizumab-mzwv
• Teriflunomide
• Tildrakizumab-asmn
• Tocilizumab
• Tofacitinib
• Trabectedin
• Tralokinumab-ldrm
• Ublituximab-xiiy
• Upadacitinib
• Ustekinumab
• Valoctocogene Roxaparvovec-rvox
• Vamorolone
• Voclosporin

Receiving this vaccine with any of the following medicines may increase the risk of certain side effects, but using both medicines may be the best option for you. If both medicines are prescribed together, your doctor may adjust the dose or how often you take one or both.

• Abatacept
• Cytomegalovirus Immune Globulin, Human
• Hepatitis B Immune Globulin
• Rabies Immune Globulin
• Respiratory Syncytial Virus Immune Globulin, Human
• Tetanus Immune Globulin
• Vaccinia Immune Globulin, Human
• Varicella-Zoster Immune Globulin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be taken around mealtime or with specific types of food due to possible interactions. Using alcohol or tobacco with some medicines may also cause interactions. Talk with your healthcare professional about how your medicine interacts with food, alcohol, or tobacco.

Other Medical Problems

Other medical issues may affect the use of this vaccine. Make sure to inform your doctor if you have any other medical problems, especially:

• Allergy to eggs, history of—This may increase the risk of a serious allergic reaction occurring again.

• Immune system problems—Use with caution. This condition may reduce the effectiveness of the vaccine.

• Immune system problems, severe or
• Tuberculosis, active and untreated—This vaccine should not be used in patients with this condition.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

• Difficulty in breathing or swallowing
• fever over 39 °C (102 °F)
• itching, especially of the feet or hands
• reddening of the skin, especially around the ears
• swelling of the eyes, face, or inside of the nose
• unusual tiredness or weakness

Less common

• Difficulty in moving
• joint pain
• muscle pain or stiffness

Incidence not known

• Back pain, sudden and severe
• black, tarry stools
• bleeding gums
• blindness or vision changes
• blood in the urine or stools
• bloody nose
• burning, crawling, itching, numbness, painful, prickling, "pins and needles", or tingling feelings
• burning of the face or mouth
• change in walking and balance
• chest tightness
• clumsiness or unsteadiness
• confusion
• cough
• dizziness
• drowsiness
• fainting
• fast heartbeat
• fever
• general feeling of illness
• heavier menstrual periods
• inability to move the arms and legs
• irritability
• large, flat, blue, or purplish patches in the skin
• muscle weakness, sudden and progressing
• nausea
• pain in the stomach, groin, or scrotum
• pain or burning with urination
• painful knees and ankles
• pinpoint red spots on the skin
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• raised red swellings on the skin, the buttocks, legs, or ankles
• seizures
• severe headache
• skin rash
• stiff neck or back
• stomach pain
• sudden numbness and weakness in the arms and legs
• swelling of the scrotum
• swollen, painful, or tender lymph glands on the side of the face or neck
• unusual bleeding or bruising
• vomiting
• weakness in the hands or feet

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
• loss of appetite
• sleepiness

Less common

• Runny nose
• sore throat
• vague feeling of bodily discomfort

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• M-M-R II

Available Dosage Forms:

• Powder for Solution
• Powder for Suspension

Therapeutic Class: Vaccine, Live

A nurse or other trained health professional will give your child this vaccine. It is given as a shot under your skin (usually in the thighs) or into one of your muscles.

This vaccine is given in 2 doses. First dose is given at 12 to 15 months of age, while the second dose is given at 4 to 6 years of age. If this vaccine is not given on time, 2 doses will be given at least 4 weeks apart.

If you have received 1 dose of another authorized or approved measles, mumps, and rubella vaccine, you may receive a second dose of Priorix® to complete your vaccination series.