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Methylcobalamin (vitamin B12)

Generic name: methylcobalamin (vitamin B12) oral

Brand names: Methyl B-12, Vitamin B12 Methylcobalamin

Last updated November 2, 2026 0 views
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What is methylcobalamin?

Methylcobalamin is the active form of vitamin B12 that adults can take by itself or with other vitamins as a dietary supplement. Vitamin B12 is essential for the brain and nerves, and for making red blood cells.

Methylcobalamin may also be used for reasons that are not mentioned in this medication guide.

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How should I take methylcobalamin?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Do not use more of this product than what is recommended on the label.

You may also consult the Office of Dietary Supplements of the NIH, or the USDA Nutrient Database of recommended daily allowances for more information.

Swallow the capsule whole and do not crush, chew, break, or open it.

Your dose may change if you switch to a different brand, strength, or form of methylcobalamin. Avoid medication errors by using it exactly as directed on the label, or as prescribed by your doctor.

You must chew the chewable tablet before you swallow it.

Do not swallow a lozenge, disintegrating tablet, or sublingual tablet whole. Allow it to dissolve in your mouth without chewing. The sublingual tablet should be placed under your tongue.

You may need frequent blood tests, and your next dose may be delayed based on the results.

Store in the original container at room temperature away from moisture, heat, and light.

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Warnings

Follow all directions on the product label and package.

Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

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Before taking this medicine

You should not use methylcobalamin if you are allergic to vitamin B12 or cobalt.

Ask your doctor or pharmacist before taking methylcobalamin if you have any health issues.

Inform your doctor if you are pregnant or breastfeeding.

Do not give any herbal or health supplement to a child without medical advice.

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Methylcobalamin side effects

Get emergency medical help if you notice signs of an allergic reaction: hives, trouble breathing, or swelling of your face, lips, tongue, or throat.

You may experience less serious side effects, and it is possible to have none at all.

This is not a complete list of side effects, and others may happen. Contact your doctor for medical advice regarding side effects. You can report side effects to the FDA at 1-800-FDA-1088.

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What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is nearly time for your next dose. Do not take two doses at once.

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What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Avoid drinking large amounts of alcohol. Heavy drinking can make it harder for your body to absorb methylcobalamin.

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What other drugs will affect methylcobalamin?

Do not take methylcobalamin without medical advice if you are using any of the following medications:

  • oral diabetes medicine that contains metformin; or
  • medicines that reduce stomach acid, such as cimetidine, omeprazole, lansoprazole, Nexium, Prevacid, Prilosec, Zantac, and others.

This list is not complete. Other drugs may affect methylcobalamin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

This section was rewritten for readability and reviewed for meaning.

Related medicines

Before you take this medicine: the information on this page is general and may not cover your personal circumstances. Read the label supplied with your medicine and ask a pharmacist or doctor if you are unsure, especially if you are pregnant, breastfeeding, taking other medicines or managing a long-term condition.
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Content is provided for education and is not medical advice. See our medical disclaimer.