Micronase (Oral)

Glyburide is used to treat high blood sugar levels caused by a type of diabetes mellitus (sugar diabetes) known as type 2 diabetes. In type 2 diabetes, your body does not properly store excess sugar, causing sugar to stay in your bloodstream. Long-term high blood sugar can lead to serious health issues in the future.

A proper diet is the first step in managing type 2 diabetes, but often medicines are necessary to assist your body. Glyburide is part of a group of medicines called sulfonylureas. It helps your pancreas release more insulin into the bloodstream. This medicine can be used alone or with another oral medicine like metformin.

This medicine is available only with your doctor's prescription.

It is very important for your doctor to check your progress during regular visits to ensure that this medicine is working properly. Blood tests may be necessary to look for unwanted effects.

It is very important to carefully follow any instructions from your health care team about:

• Alcohol—Drinking alcohol may lead to severe low blood sugar. Discuss this with your health care team.
• Counseling—Other family members should learn how to prevent side effects or help if they occur. Additionally, patients with diabetes may need special counseling about changes in diabetes medicine dosing that might happen due to lifestyle changes, such as changes in exercise and diet. Counseling on contraception and pregnancy may also be needed because of complications that can arise in patients with diabetes during pregnancy.
• Travel—Keep your recent prescription and medical history with you. Be prepared for emergencies as you normally would. Adjust for time zone changes and keep your meal times as close as possible to your usual meal times.
• In case of emergency—There may be times when you need emergency assistance for a problem related to your diabetes. Be prepared for these emergencies. It is a good idea to always wear a medical identification (ID) bracelet or necklace. Also, carry an ID card in your wallet or purse that indicates you have diabetes and lists all your medicines.

Contact your doctor immediately if you begin to experience chest pain or discomfort, nausea, pain or discomfort in the arms, jaw, back, or neck, shortness of breath, sweating, or vomiting while using this medicine. These may be signs of a serious heart issue, including a heart attack.

Taking too much glyburide can cause low blood sugar (hypoglycemia) under certain conditions. Symptoms of low blood sugar must be treated before they lead to unconsciousness (passing out). Different people may experience different symptoms of low blood sugar. It is important for you to recognize which symptoms you usually have so that you can treat them quickly and contact someone on your health care team when you need advice.

Symptoms of hypoglycemia (low blood sugar) include anxiety, behavior changes similar to being drunk, blurred vision, cold sweats, confusion, cool, pale skin, difficulty thinking, drowsiness, excessive hunger, fast heartbeat, persistent headache, nausea, nervousness, nightmares, restless sleep, shakiness, slurred speech, or unusual tiredness or weakness.

If symptoms of low blood sugar occur, consume glucose tablets or gel, corn syrup, honey, or sugar cubes; or drink fruit juice, non-diet soft drinks, or sugar dissolved in water. Additionally, check your blood for low blood sugar. Glucagon is used in emergencies when severe symptoms like seizures (convulsions) or unconsciousness happen. Keep a glucagon kit available, along with a syringe or needle, and know how to use it. Other members of your household should also know how to use it.

Do not take this medicine if you are also using bosentan (Tracleer®). Also, ensure your doctor is aware of all other medicines you are using for diabetes, including insulin.

In deciding to use a medicine, the risks of taking the medicine must be weighed against the benefits. This is a decision you and your doctor will make together. For this medicine, consider the following:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also inform your healthcare professional if you have other allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been conducted to determine how glyburide affects children. Safety and effectiveness have not been established.

Geriatric

Studies to date have not shown any specific issues for elderly patients that would limit the usefulness of glyburide. However, older patients are more likely to have age-related liver or kidney issues, which may require a dose adjustment for those taking glyburide.

Breast Feeding

There are no adequate studies in women to determine the risk to infants when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Some medicines should not be used together at all, while others may be used together with caution. In some cases, your doctor may need to adjust the dose or take other precautions. It is especially important that your healthcare professional knows if you are taking any of the medicines listed below. The following interactions have been selected for their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Bosentan

Using this medicine with any of the following medicines is usually not recommended, but may be necessary in some cases. If both medicines are prescribed together, your doctor may adjust the dose or how often you use one or both of the medicines.

• Abiraterone Acetate
• Acarbose
• Alogliptin
• Aspirin
• Bexagliflozin
• Capecitabine
• Chloroquine
• Chlorothiazide
• Chlorthalidone
• Ciprofloxacin
• Darolutamide
• Delafloxacin
• Desmopressin
• Disopyramide
• Dulaglutide
• Elexacaftor
• Enasidenib
• Encorafenib
• Enoxacin
• Entacapone
• Fluconazole
• Furosemide
• Gatifloxacin
• Gemifloxacin
• Grepafloxacin
• Hydrochlorothiazide
• Hydroflumethiazide
• Hydroxychloroquine
• Indapamide
• Insulin
• Insulin Aspart, Recombinant
• Insulin Bovine
• Insulin Degludec
• Insulin Detemir
• Insulin Glargine, Recombinant
• Insulin Glulisine
• Insulin Lispro, Recombinant
• Lanreotide
• Leflunomide
• Leniolisib
• Letermovir
• Levofloxacin
• Liraglutide
• Lixisenatide
• Lomefloxacin
• Mavacamten
• Metformin
• Methotrexate
• Metolazone
• Metreleptin
• Midostaurin
• Moxifloxacin
• Norfloxacin
• Octreotide
• Ofloxacin
• Pasireotide
• Phenobarbital
• Pioglitazone
• Polythiazide
• Porfimer
• Pramlintide
• Primidone
• Semaglutide
• Simeprevir
• Sitagliptin
• Somatrogon-ghla
• Sotagliflozin
• Sparfloxacin
• Sparsentan
• Sulfamethoxazole
• Teriflunomide
• Thioctic Acid
• Tocilizumab
• Triamterene
• Trofinetide
• Trovafloxacin

Using this medicine with any of the following medicines may increase the risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acebutolol
• Aminolevulinic Acid
• Atenolol
• Betaxolol
• Bisoprolol
• Bitter Melon
• Carteolol
• Carvedilol
• Celiprolol
• Clarithromycin
• Colesevelam
• Cyclosporine
• Eltrombopag
• Esmolol
• Fenugreek
• Fluvastatin
• Gemfibrozil
• Glucomannan
• Isocarboxazid
• Labetalol
• Levobunolol
• Linezolid
• Methylene Blue
• Metipranolol
• Metoprolol
• Nadolol
• Nebivolol
• Oxprenolol
• Ozanimod
• Penbutolol
• Phenelzine
• Pindolol
• Practolol
• Procarbazine
• Propranolol
• Psyllium
• Rasagiline
• Rifampin
• Rifapentine
• Safinamide
• Saxagliptin
• Selegiline
• Sotalol
• Timolol
• Tirzepatide
• Tranylcypromine
• Voriconazole
• Warfarin

Interactions with Food/Tobacco/Alcohol

Some medicines should not be taken at or around meal times or with specific types of food due to possible interactions. Using alcohol or tobacco with some medicines may also cause interactions. The following interactions have been selected for their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be necessary in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Ethanol

Other Medical Problems

Other medical issues may affect how this medicine works. Make sure to tell your doctor if you have any other medical problems, especially:

• Alcohol intoxication or
• Underactive adrenal glands or
• Underactive pituitary gland or
• Undernourished condition or
• Weakened physical condition or
• Any other condition that causes low blood sugar—Patients with these conditions may be more likely to have low blood sugar while taking glyburide.

• Diabetic ketoacidosis (ketones in the blood) or
• Type I diabetes—Should not be used in patients with these conditions.

• Fever or
• Infection or
• Surgery or
• Trauma—These situations may cause temporary issues with blood sugar control, and your doctor may want to treat you temporarily with insulin.

• Glucose-6-phosphate dehydrogenase (G6PD) deficiency (an enzyme problem)—May cause hemolytic anemia (a blood disorder) in patients with this condition.

• Heart disease—Use with caution. May worsen this condition.

• Kidney disease or
• Liver disease—Use with caution. Effects may be increased because the body may remove the medicine more slowly.

Along with its necessary effects, this medicine may cause some unwanted effects. Not all of these side effects may happen, but if they do, you might need medical attention.

Check with your doctor right away if any of the following side effects occur:

Less common

• Difficulty swallowing
• Dizziness
• Fast heartbeat
• Hives, itching, skin rash
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Tightness in the chest
• Trouble breathing
• Unusual tiredness or weakness

Rare

• Abdominal or stomach pain
• Chills
• Clay-colored stools
• Dark urine
• Diarrhea
• Fever
• Headache
• Light-colored stools
• Loss of appetite
• Nausea and vomiting
• Unpleasant breath odor
• Upper right abdominal or stomach pain
• Vomiting blood
• Yellow eyes and skin

Incidence not known

• Agitation
• Back, leg, or stomach pains
• Bleeding gums
• Blood in the urine or stools
• Bloody, black, or tarry stools
• Blurred vision
• Change in near or distance vision
• Chest pain
• Coma
• Confusion
• Convulsions
• Cough or hoarseness
• Decreased urine output
• Depression
• Difficulty focusing eyes
• Fast or irregular heartbeat
• Fluid-filled skin blisters
• General body swelling
• High fever
• Hostility
• Increased thirst
• Irritability
• Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• Lethargy
• Lower back or side pain
• Muscle pain or cramps
• Muscle twitching
• Nosebleeds
• Painful or difficult urination
• Pale skin
• Pinpoint red spots on the skin
• Rapid weight gain
• Sensitivity to the sun
• Skin thinness
• Sore throat
• Sores, ulcers, or white spots on the lips or in the mouth
• Stupor
• Swelling of the face, ankles, or hands
• Swollen or painful glands
• Unusual bleeding or bruising

Get emergency help right away if any of the following symptoms of overdose occur:

Symptoms of overdose

• Anxiety
• Cold sweats
• Cool, pale skin
• Increased hunger
• Nervousness
• Nightmares
• Shakiness
• Slurred speech

Some side effects may occur that usually do not require medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to suggest ways to prevent or lessen some of these side effects. Check with your health care professional if any of the following side effects continue, become bothersome, or if you have any questions about them:

Less common

• Indigestion
• Passing gas

Incidence not known

• Difficulty moving
• Joint pain
• Redness or other discoloration of the skin
• Severe sunburn
• Swollen joints

Other side effects not listed may also happen in some patients. If you notice any other effects, consult your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Diabeta
• Glycron
• Glynase Pres-Tab
• Micronase

In Canada

• Euglucon

Available Dosage Forms:

• Tablet

Therapeutic Class: Hypoglycemic

Chemical Class: 2nd Generation Sulfonylurea

Carefully follow the special meal plan your doctor gave you. This is the most important part of controlling your condition, and is necessary if the medicine is to work properly. Also, exercise regularly and test for sugar in your blood or urine as directed.

Use only the brand of this medicine that your doctor prescribed. Different brands may not work the same way.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For type 2 diabetes:For oral dosage form (tablets): Adults—At first, 2.5 to 5 milligrams (mg) once a day taken with breakfast or the first main meal. Your doctor may adjust your dose if needed. However, the dose is usually not more than 20 mg per day. Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.