Mitomycin

Mitomycin is used along with other cancer drugs to treat cancer of the stomach and pancreas.

Mitomycin may also be used for reasons not mentioned in this medication guide.

Mitomycin is given as an infusion into a vein. A healthcare provider will give you mitomycin.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when mitomycin is injected.

Some people receiving mitomycin have developed ulcers on the skin where an injection was given, or on other areas of the body. Skin changes may occur several weeks or months after a mitomycin injection. Call your doctor if you notice any redness, sores, oozing, or other skin changes during or after your treatment with mitomycin.

Mitomycin affects your immune system. You may get infections more easily. You will need frequent medical tests, and your next dose may be delayed based on the results.

Mitomycin can have long-lasting effects on your body. You may also need medical tests for a short time after your last dose.

Mitomycin can harm red blood cells, which may lead to irreversible kidney failure. Inform your doctor immediately if you notice unusual bruising or bleeding, pale skin, confusion, tiredness or irritability, stomach pain, bloody diarrhea, red or pink urine, swelling, rapid weight gain, or if you are urinating very little or not at all.

Mitomycin can also weaken (suppress) your immune system, making it easier for you to get an infection. Contact your doctor if you experience signs of infection such as fever, weakness, cold or flu symptoms, skin sores, or frequent or recurring illnesses.

You should not receive treatment with mitomycin if you are allergic to it, or if you have:

• low levels of platelets in your blood;
• bone marrow suppression; or
• active bleeding or any risk of bleeding.

Inform your doctor if you have ever had:

• kidney disease;
• heart disease; or
• asthma, chronic obstructive pulmonary disease (COPD), sleep apnea, or another breathing disorder.

Mitomycin may harm an unborn baby. Use effective birth control to prevent pregnancy, and inform your doctor if you become pregnant.

You should not breastfeed while using mitomycin.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Mitomycin can harm red blood cells, which may lead to irreversible kidney failure. Tell your doctor right away if you notice unusual bruising or bleeding, pale skin, confusion, tiredness or irritability, stomach pain, bloody diarrhea, red or pink urine, swelling, rapid weight gain, or little or no urinating.

Mitomycin may cause serious side effects. Call your doctor immediately if you have:

• signs of infection (fever, weakness, cold or flu symptoms, skin sores, frequent or recurring illness);
• wheezing, chest tightness, a new or worsening cough, trouble breathing;
• blisters or ulcers in your mouth, red or swollen gums, trouble swallowing; or
• pain, burning, redness, swelling, irritation, or skin changes where the injection was given.

Common side effects of mitomycin may include:

• fever or other signs of infection;
• nausea, vomiting, diarrhea, loss of appetite;
• mouth sores;
• drowsiness, headache;
• blurred vision; or
• temporary hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Usual Adult Dose for Stomach Cancer:

After full hematologic recovery from any previous chemotherapy: 20 mg/m2 IV at 6- to 8-week intervalsComments:-Because of cumulative myelosuppression, patients should be reevaluated after each course of this drug and the dose reduced if the patient has experienced toxicity. -Doses greater than 20 mg/m2 have not been shown to be more effective and are more toxic than lower doses.Uses: -For disseminated adenocarcinoma of the stomach in proven combination with other approved chemotherapeutic agents or as palliative treatment when other modalities have failed-For disseminated adenocarcinoma of the pancreas in proven combination with other approved chemotherapeutic agents or as palliative treatment when other modalities have failed

Usual Adult Dose for Gastric Cancer:

After full hematologic recovery from any previous chemotherapy: 20 mg/m2 IV at 6- to 8-week intervalsComments:-Because of cumulative myelosuppression, patients should be reevaluated after each course of this drug and the dose reduced if the patient has experienced toxicity. -Doses greater than 20 mg/m2 have not been shown to be more effective and are more toxic than lower doses.Uses: -For disseminated adenocarcinoma of the stomach in proven combination with other approved chemotherapeutic agents or as palliative treatment when other modalities have failed-For disseminated adenocarcinoma of the pancreas in proven combination with other approved chemotherapeutic agents or as palliative treatment when other modalities have failed

Call your doctor for instructions if you miss an appointment for your Mitomycin injection.

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

Avoid being around people who are sick or have infections. Tell your doctor right away if you notice any signs of infection.

Avoid activities that could increase your risk of bleeding or injury. Be extra careful to prevent bleeding while shaving or brushing your teeth.

Other drugs may affect mitomycin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.